Navigation Links
Study Points to New Treatments for Polycystic Kidney Disease
Date:4/11/2008

Molecules called CFTR inhibitors show promise in slowing growth of masses

FRIDAY, April 11 (HealthDay News) -- Compounds called CFTR inhibitors show promise in slowing the progression of polycystic kidney disease (PKD), according to preliminary research conducted at the University of California, San Francisco, School of Medicine.

PKD is the most common kind of genetic kidney disease. Patients develop cysts on the kidneys, which progressively increase in size and number. As a result, the kidneys become enlarged, eventually leading to kidney failure. There is no cure for PKD.

It's believed the accumulation of fluid in the cysts is related to chloride secretion, which is affected by the CFTR (cystic fibrosis transmembrane conductance regulator) gene, according to background information in a news release about the research.

"The CFTR inhibitors could be the basis of a lifelong treatment to slow renal cyst growth and decline in renal function, prolonging dialysis-free patient survival," researcher Dr. Alan S. Verkman said in a prepared statement.

In laboratory tests, he identified a few CFTR inhibitors that reduced the number and growth of cysts by more than 80 percent. He then tested these inhibitors in mice genetically engineered to develop a condition similar to PKD.

Mice treated with these CFTR inhibitors for up to seven days had significantly slower cyst expansion and kidney enlargement, and better preservation of kidney function. There was no evidence that the CFTR inhibitors harmed kidney function.

The findings indicate that CFTR plays a role in the growth of kidney cysts and suggest that CFTR inhibitors may prove useful in treating PKD. However, much more research needs to be done, Verkman said.

"The mouse model of PKD is not the real human disease for many reasons, such as the more rapid progression of disease in mice. Clinical trials will be needed to determine the efficacy of these compounds in human PKD," he said.

The research was expected to be published in the July issue of the Journal of the American Society of Nephrology.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about PKD.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, April 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. MRI better than MDCT in detecting endoleaks, study says
2. Personality study shows risk of first depression episode late in life
3. 3T MRI plays significant role in detecting prostate cancer, study says
4. Study shows doctors offices can help stem abuse of Oxycontin, other narcotic painkillers
5. Quintiles Ranks First in Pan-European Clinical Investigator Study
6. Study Showed Minimally Invasive Surgery Reduced Risk of Hospital-Acquired Infections Compared to Open Surgery
7. NEJM study demonstrates carotid stenting with embolic protection is comparable to surgery
8. Egg Consumption Poses Risks for Diabetic Men: Study
9. Haemacure Discloses Positive Results of a preclinical study of its fibrin sealant in adhesion prevention and opens a new opportunity in a market with a significant unmet medical need
10. Landmark Study Aims to Improve Osteoporosis Care Standards Worldwide
11. Forecasting MDs prescriptions choice? Ask their patients, says Management Insights study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2016)... ... May 30, 2016 , ... Another ER facility operated by ... located at 3960 Legacy Drive, Plano, TX and is open 24 hours daily. , ... followed by a medical open house. The Jasper High School band entertained attendees and ...
(Date:5/28/2016)... ... May 28, 2016 , ... SuperCloset is proud to officially launch our ... day issues, struggles and obstacles veterans’ need to overcome in order to face their ... or retired military veteran(s) with a donated SuperCloset product based on the needs and ...
(Date:5/28/2016)... (PRWEB) , ... May 28, 2016 , ... In a part of the city where’s ... city’s new farm-to-table Kelowna restaurants is hoping to attract diners with a taste ... & Suites officially opened the doors to Cornerstone Grill, an urban casual restaurant focusing ...
(Date:5/27/2016)... ... ... W.S. Badger Co. Inc ., the maker of certified organic and ... of the best small businesses for new dads by Fatherly, the digital lifestyle guide ... progressive benefits to new parents on the organization’s 2016 Best Places to Work ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities ... within the industry, from leading advocates, associations and industry leaders such as Bioness. ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... & Expo earlier this month, the numbers and momentum ... continue to climb into the billions, more research and ... released 4th Edition State of Legal Marijuana Markets Report ... cannabis-focused data-analysis firm, much of the increase in sector ...
(Date:5/25/2016)... Digital Health Dialog, LLC dba EngagedMedia ... US Patent and Trademark Office of U.S. Patent ... for electronic opt-­in and processing of discount coupons ... compliance and otherwise. Logo - http://photos.prnewswire.com/prnh/20160524/371583LOGO ... "Our technology allows for individuals to opt­-in to ...
(Date:5/25/2016)... May 25, 2016 Inivata, ... precision of circulating tumour DNA (ctDNA) analysis to ... appointment of Professor Clive Morris as ... across the clinical development programme, scientific collaborations, and ... deliver significant improvements in clinical outcomes for patients. ...
Breaking Medicine Technology: