Navigation Links
Study Points to New Treatments for Polycystic Kidney Disease
Date:4/11/2008

Molecules called CFTR inhibitors show promise in slowing growth of masses

FRIDAY, April 11 (HealthDay News) -- Compounds called CFTR inhibitors show promise in slowing the progression of polycystic kidney disease (PKD), according to preliminary research conducted at the University of California, San Francisco, School of Medicine.

PKD is the most common kind of genetic kidney disease. Patients develop cysts on the kidneys, which progressively increase in size and number. As a result, the kidneys become enlarged, eventually leading to kidney failure. There is no cure for PKD.

It's believed the accumulation of fluid in the cysts is related to chloride secretion, which is affected by the CFTR (cystic fibrosis transmembrane conductance regulator) gene, according to background information in a news release about the research.

"The CFTR inhibitors could be the basis of a lifelong treatment to slow renal cyst growth and decline in renal function, prolonging dialysis-free patient survival," researcher Dr. Alan S. Verkman said in a prepared statement.

In laboratory tests, he identified a few CFTR inhibitors that reduced the number and growth of cysts by more than 80 percent. He then tested these inhibitors in mice genetically engineered to develop a condition similar to PKD.

Mice treated with these CFTR inhibitors for up to seven days had significantly slower cyst expansion and kidney enlargement, and better preservation of kidney function. There was no evidence that the CFTR inhibitors harmed kidney function.

The findings indicate that CFTR plays a role in the growth of kidney cysts and suggest that CFTR inhibitors may prove useful in treating PKD. However, much more research needs to be done, Verkman said.

"The mouse model of PKD is not the real human disease for many reasons, such as the more rapid progression of disease in mice. Clinical trials will be needed to determine the efficacy of these compounds in human PKD," he said.

The research was expected to be published in the July issue of the Journal of the American Society of Nephrology.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about PKD.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, April 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. MRI better than MDCT in detecting endoleaks, study says
2. Personality study shows risk of first depression episode late in life
3. 3T MRI plays significant role in detecting prostate cancer, study says
4. Study shows doctors offices can help stem abuse of Oxycontin, other narcotic painkillers
5. Quintiles Ranks First in Pan-European Clinical Investigator Study
6. Study Showed Minimally Invasive Surgery Reduced Risk of Hospital-Acquired Infections Compared to Open Surgery
7. NEJM study demonstrates carotid stenting with embolic protection is comparable to surgery
8. Egg Consumption Poses Risks for Diabetic Men: Study
9. Haemacure Discloses Positive Results of a preclinical study of its fibrin sealant in adhesion prevention and opens a new opportunity in a market with a significant unmet medical need
10. Landmark Study Aims to Improve Osteoporosis Care Standards Worldwide
11. Forecasting MDs prescriptions choice? Ask their patients, says Management Insights study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in ... in honor of the city’s history as home to some of the world’s leading ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
Breaking Medicine Technology: