Navigation Links
Study Points to New Treatments for Polycystic Kidney Disease
Date:4/11/2008

Molecules called CFTR inhibitors show promise in slowing growth of masses

FRIDAY, April 11 (HealthDay News) -- Compounds called CFTR inhibitors show promise in slowing the progression of polycystic kidney disease (PKD), according to preliminary research conducted at the University of California, San Francisco, School of Medicine.

PKD is the most common kind of genetic kidney disease. Patients develop cysts on the kidneys, which progressively increase in size and number. As a result, the kidneys become enlarged, eventually leading to kidney failure. There is no cure for PKD.

It's believed the accumulation of fluid in the cysts is related to chloride secretion, which is affected by the CFTR (cystic fibrosis transmembrane conductance regulator) gene, according to background information in a news release about the research.

"The CFTR inhibitors could be the basis of a lifelong treatment to slow renal cyst growth and decline in renal function, prolonging dialysis-free patient survival," researcher Dr. Alan S. Verkman said in a prepared statement.

In laboratory tests, he identified a few CFTR inhibitors that reduced the number and growth of cysts by more than 80 percent. He then tested these inhibitors in mice genetically engineered to develop a condition similar to PKD.

Mice treated with these CFTR inhibitors for up to seven days had significantly slower cyst expansion and kidney enlargement, and better preservation of kidney function. There was no evidence that the CFTR inhibitors harmed kidney function.

The findings indicate that CFTR plays a role in the growth of kidney cysts and suggest that CFTR inhibitors may prove useful in treating PKD. However, much more research needs to be done, Verkman said.

"The mouse model of PKD is not the real human disease for many reasons, such as the more rapid progression of disease in mice. Clinical trials will be needed to determine the eff
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. MRI better than MDCT in detecting endoleaks, study says
2. Personality study shows risk of first depression episode late in life
3. 3T MRI plays significant role in detecting prostate cancer, study says
4. Study shows doctors offices can help stem abuse of Oxycontin, other narcotic painkillers
5. Quintiles Ranks First in Pan-European Clinical Investigator Study
6. Study Showed Minimally Invasive Surgery Reduced Risk of Hospital-Acquired Infections Compared to Open Surgery
7. NEJM study demonstrates carotid stenting with embolic protection is comparable to surgery
8. Egg Consumption Poses Risks for Diabetic Men: Study
9. Haemacure Discloses Positive Results of a preclinical study of its fibrin sealant in adhesion prevention and opens a new opportunity in a market with a significant unmet medical need
10. Landmark Study Aims to Improve Osteoporosis Care Standards Worldwide
11. Forecasting MDs prescriptions choice? Ask their patients, says Management Insights study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Cannabix Technologies Inc. (CSE: BLO) (OTC ... Iannapollo has become an Advisor to Cannabix Technologies, developer ... and workplace testing. Mr. Iannapollo is an expert on ... experience in the oil and gas industry, working for ... employer, and DOT compliance policies and strategies. He also ...
(Date:4/27/2015)... The global coagulation analyzers market is estimated to ... however, it is expected to witness high growth ... Brazil in the next five years. Growth in ... such as increasing adoption of automated hemostasis instruments ... developments in high-sensitivity point-of-care coagulation analyzers and introduction ...
(Date:4/27/2015)... The Global Pharmaceutical Packaging Market 2015 – ... 5.9% during the period 2015 – 2019. Plastics will ... packaging market, mainly due to their cost effectiveness and ... is extremely fragmented with the presence of several global ... market with the rest being occupied by several international ...
(Date:4/27/2015)... April 27, 2015 On the top ... dramatic nighttime skyline of beautiful Los Angeles, CA, Per ... star of “The Real Housewives of Orange County” Gretchen ... Entertainment’s EcoLuxe Lounge and the “Salute to the Oscars” ... for substance abuse founded by Wickstrom, Rossi felt that ...
(Date:4/27/2015)... The Sanford J. Grossman Charitable Trust, founded ... has committed $3 million to establish the Dr. Sanford ... Disease at the Icahn School of Medicine at Mount ... for treatment of Crohn’s disease, with the overarching goal ... a chronic inflammatory disorder of the bowel first described ...
Breaking Medicine News(10 mins):Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 2Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 3Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 4Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 2Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 4Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2Health News:Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center at Mount Sinai 2Health News:Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center at Mount Sinai 3
... more benefit, experts say , TUESDAY, April 6 (HealthDay News) ... pain has exploded in the past six years, even ... treatments and not necessarily more effective, a study finds. , ... big the increase was," said Dr. Richard A. Deyo, professor ...
... proportion of older middle-aged Americans who report disabilities related ... contrast to the disability decline that has been found ... new study by the RAND Corporation and the University ... proportion of Americans aged 50 to 64 who reported ...
... designed to reduce HIV/STDs previously used exclusively by academic ... an important component in national strategies to curtail the ... can be reached. , A new study by ... proven HIV/STD risk-reduction intervention would work when led by ...
... health information technology will support care between office visits, ... lives. An evaluation in the April Health Affairs ... new approach: Routinely ask patients how they like it ... ask patients whether the health information technology they use ...
... 6, 2010 The nation,s preterm birth rate dropped for the ... percent decline in the preterm birth rate, according to a report ... March of Dimes officials say they are encouraged and hope that ... are based on 99.9 percent of U.S. births and the improvement ...
... , ... Spiritual Politics and Builders of the Dawn reveals a new world growing all around us and ... ... state of our planet in 2010 may make some people want to go into hiding. But ...
Cached Medicine News:Health News:Complex Spinal Operations Soar Despite Drawbacks 2Health News:Complex Spinal Operations Soar Despite Drawbacks 3Health News:Middle-aged Americans report more mobility-related disabilities 2Health News:Middle-aged Americans report more mobility-related disabilities 3Health News:Roll-out of proven HIV/STD risk-reduction intervention with teens by community groups successful 2Health News:Want better health information technology? Ask patients how they want it 2Health News:Preterm birth rate drops 3 percent 2Health News:The Practical Visionary Offers Eight Keys to Surviving and Thriving in the 21st Century, 2Health News:The Practical Visionary Offers Eight Keys to Surviving and Thriving in the 21st Century, 3Health News:The Practical Visionary Offers Eight Keys to Surviving and Thriving in the 21st Century, 4Health News:The Practical Visionary Offers Eight Keys to Surviving and Thriving in the 21st Century, 5
(Date:4/24/2015)... April 24, 2015 In today,s ever-changing ... groups around the world to access diverse skill ... While there are many areas to misstep in ... which best practices are necessary and beneficial in ... According to research by benchmarking firm, Best ...
(Date:4/24/2015)... -- Boston Scientific Corporation (NYSE: BSX ) is scheduled ... Healthcare Conference on May 6 in Boston ... and chief financial officer, and Susie Lisa , vice ... answer session regarding the company with the host analyst at ... the presentation and question and answer session will be available ...
(Date:4/24/2015)... , April 24, 2015 ... portfolio of automated, indication-specific planning tools for radiosurgery/SBRT ... focused software applications aimed at enhancing the workflow ... and spine introduced in 2013 - comes full ... (SRS) planning tools. These new Elements enable on-the-fly ...
Breaking Medicine Technology:Work Around the Clock: Building Effective Global Capabilities 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2
... March 1, 2011 Developed by inventor John Vito and represented ... in this lot disclose an advanced medical inhaler design that is ... (Logo:   http://photos.prnewswire.com/prnh/20100614/CG20517LOGO ) The patents will ... IP Auction on March 31, 2011 in New York City. ...
... may not be enough to impact the productivity of ... and coronary artery disease.  That key finding and others ... Alere Health and other industry experts at the Integrated ... (NBCH) Conference in San Francisco, Tuesday, March 1. ...
Cached Medicine Technology:An Easier Way to Breathe Better - ICAP Ocean Tomo Announces an Advanced Medical Inhaler Design 2Alere Previews Findings from Key Research Study on Medication Adherence at Integrated Benefits Institute Conference 2Alere Previews Findings from Key Research Study on Medication Adherence at Integrated Benefits Institute Conference 3
... Mouthpiece 7FT O 2 Tubing Tee Adapter, ... for fast treatment times , ... (higher percentage of respirable particles) than conventional nebulizers, ... Max 10™ disposable nebulizers deliver fast and effective ...
Nebulizer Custom Kit...
... Anesthesia and Respiratory Products, ,Westmed designs, ... for Anesthesia and Respiratory professionals. Our mission ... enhance the clinician's ability to deliver quality ... the bottom line. , ,Our web ...
... Products, ,Westmed designs, manufacturers and markets ... Respiratory professionals. Our mission is to design ... ability to deliver quality medical care while ... , ,Our web site is designed ...
Medicine Products: