Navigation Links
Study Points to Molecular Origins of Celiac Disease
Date:7/21/2010

By Melissa Lee Phillips
HealthDay Reporter

WEDNESDAY, July 21 (HealthDay News) -- Scientists believe they've identified the molecular triggers of celiac disease, a finding they say could lead to the first drugs to tame the chronic, painful gut disorder.

People with celiac disease are intolerant to the protein gluten, which is found in wheat, barley and rye. Consuming these foods triggers an immune reaction that damages the lining of the small intestine, which can prevent the body from absorbing essential vitamins and nutrients.

Currently, the only treatment for celiac disease is adoption of a gluten-free diet, which means avoiding many types of bread, pasta, cereal and other foods. But gluten contamination in many foods makes it difficult to avoid and leads to long-lasting intestinal damage in some patients, said study senior author Robert Anderson, head of the celiac disease research laboratory at the Walter and Eliza Hall Institute of Medical Research in Parkville, Australia.

Regulating the aberrant immune response to gluten with a drug "would be a much more efficient way of dealing with celiac disease," Anderson said, but an incomplete understanding of how the immune system responds to gluten has prevented researchers from developing such therapies.

Gluten actually consists of many different protein components, and it's been unclear which of these fragments induces the immune response seen in celiac disease.

"You can't design drugs for celiac disease until you know the parts of the gluten that are driving the condition," Anderson explained.

During their investigation, he and his colleagues analyzed immune responses in the blood of more than 200 celiac disease patients after they had consumed meals containing gluten.

The researchers screened the blood samples for responses to thousands of different protein fragments (peptides) found in gluten, and they found that the patients' immune systems seemed to be responding negatively to only three of them.

That suggests that "a very precise trigger is driving the immune response," Anderson said. "The problem is not so much gluten, it's really these three peptides."

The authors also noted that most of the immune response to gluten appears tied to a single type of immune system cell, called the T cell.

The results are published in the July 21 issue of Science Translational Medicine.

According to Dr. Alessio Fasano of the University of Maryland School of Medicine in Baltimore, the evidence is indeed strong that these three protein fragments trigger the celiac immune response, but "I'm not sure that it's the end of the story," he added. It remains possible that the screen didn't catch all the gluten components involved in the immune response, Fasano said.

The findings will also not be relevant to everyone with celiac disease, Anderson added, since his team studied patients with a particular genetic susceptibility to the disease. Although most people with the disease show this genetic background, some do not. Anderson and his colleagues are currently working to identify which gluten proteins induce the immune response in the remainder of celiac patients.

Through Anderson's company, Nexpep, based in Ivanhoe, Australia, the researchers are also conducting phase I clinical trials on a drug based on the three gluten protein fragments they identified. The aim of the drug is to desensitize celiac patients to the offending proteins by presenting them in very controlled amounts. They expect results within the next couple of months.

The current study received funding from Nexpep, the Australian National Health and Medical Research Council, Coeliac UK, the Coeliac Research Fund, and others.

More information

Find out more about celiac disease at the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.

SOURCES: Robert Anderson, Ph.D., head, celiac disease research laboratory, Walter and Eliza Hall Institute, Parkville, Australia; Alessio Fasano, M.D., professor of pediatrics, medicine, and physiology and director of the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore; July 21, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Puts Partial Hold on Avandia Safety Study
2. Not Every ACL Tear Needs Early Surgery, Study Suggests
3. Most men in long-term study of HIV report low use of illicit drugs
4. Gladstone and Lundbeck collaborate to study neurovascular disease
5. New Study Finds HPV Vaccine Protects Against Genital Warts
6. Vaginal Gel Cuts Risk of HIV Infection, Study Shows
7. Research consortium at CHLA receives $410,000 to study leukemia and lymphoma
8. Concordia researcher leads study that finds kids reduce physical activity for heart patients
9. Study Suggests Higher Cancer Rate Among IVF Babies
10. HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study
11. Anthony S. Fauci, M.D., on results from the CAPRISA 004 microbicide study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Points to Molecular Origins of Celiac Disease
(Date:4/27/2017)... ... April 27, 2017 , ... SyncDog, Inc. , the ... MobileIron Live! 2017 in Santa Clara, California. Each year, MobileIron Live! assembles ... helping organizations maximize the benefits of mobility in their operations securely. MobileIron ...
(Date:4/27/2017)... ... , ... Are you investing in the safety of your friends and family? ... summer. While most of us assume this type of accident will never happen to ... are taking the time to learn how to respond effectively or prevent these accidents ...
(Date:4/26/2017)... Louis, Missouri (PRWEB) , ... April 26, 2017 ... ... cost, quality and clinical outcomes, today released the podcast, “Make Plans for ... in bringing value-based payment into the physician's office and how physicians and other ...
(Date:4/26/2017)... , ... April 26, 2017 , ... ... that describes the adoption of e-prescribing as measured in Part D Medicare data. ... deliver prescriptions to pharmacies, either using e-prescribing, faxes or paper. The PaPR ...
(Date:4/26/2017)... ... April 26, 2017 , ... The National Business Research ... National Registry of Emergency Medical Technicians and welcomes this organization to the ... Jan G. West, Ph.D. , CEO & Organizational Psychologist at NBRI. “This award ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... DUBLIN , April 20, 2017 ... "Global Pharmacogenomics Market Size, Market Share, Application Analysis, Regional Outlook, ... 2024" report to their offering. ... The global pharmacogenomics market was valued at US$ ... 11,938.8 Mn by 2024, expanding at a CAGR of 5.6% ...
(Date:4/20/2017)... DUBLIN , April 20, 2017 ... "Latin America Pharmaceutical Contract Manufacturing Services Market Analysis By Service ... And Segment Forecasts, 2014 - 2025" report to their ... The Latin ... USD 21.0 billion by 2025 Low drug registration ...
(Date:4/19/2017)... , April 19, 2017 The Mobile X-Ray product ... a healthy CAGR during the forecast period Mobile ... the global digital mobile X-Ray devices market, which is estimated ... 2017, expanding at a CAGR of 7% over the forecast ... opportunity of more than US$ 100 Mn in 2017 over ...
Breaking Medicine Technology: