Navigation Links
Study Points to Molecular Origins of Celiac Disease

By Melissa Lee Phillips
HealthDay Reporter

WEDNESDAY, July 21 (HealthDay News) -- Scientists believe they've identified the molecular triggers of celiac disease, a finding they say could lead to the first drugs to tame the chronic, painful gut disorder.

People with celiac disease are intolerant to the protein gluten, which is found in wheat, barley and rye. Consuming these foods triggers an immune reaction that damages the lining of the small intestine, which can prevent the body from absorbing essential vitamins and nutrients.

Currently, the only treatment for celiac disease is adoption of a gluten-free diet, which means avoiding many types of bread, pasta, cereal and other foods. But gluten contamination in many foods makes it difficult to avoid and leads to long-lasting intestinal damage in some patients, said study senior author Robert Anderson, head of the celiac disease research laboratory at the Walter and Eliza Hall Institute of Medical Research in Parkville, Australia.

Regulating the aberrant immune response to gluten with a drug "would be a much more efficient way of dealing with celiac disease," Anderson said, but an incomplete understanding of how the immune system responds to gluten has prevented researchers from developing such therapies.

Gluten actually consists of many different protein components, and it's been unclear which of these fragments induces the immune response seen in celiac disease.

"You can't design drugs for celiac disease until you know the parts of the gluten that are driving the condition," Anderson explained.

During their investigation, he and his colleagues analyzed immune responses in the blood of more than 200 celiac disease patients after they had consumed meals containing gluten.

The researchers screened the blood samples for responses to thousands of different protein fragments (peptides) found in gluten, and they found that the patients' immune systems seemed to be responding negatively to only three of them.

That suggests that "a very precise trigger is driving the immune response," Anderson said. "The problem is not so much gluten, it's really these three peptides."

The authors also noted that most of the immune response to gluten appears tied to a single type of immune system cell, called the T cell.

The results are published in the July 21 issue of Science Translational Medicine.

According to Dr. Alessio Fasano of the University of Maryland School of Medicine in Baltimore, the evidence is indeed strong that these three protein fragments trigger the celiac immune response, but "I'm not sure that it's the end of the story," he added. It remains possible that the screen didn't catch all the gluten components involved in the immune response, Fasano said.

The findings will also not be relevant to everyone with celiac disease, Anderson added, since his team studied patients with a particular genetic susceptibility to the disease. Although most people with the disease show this genetic background, some do not. Anderson and his colleagues are currently working to identify which gluten proteins induce the immune response in the remainder of celiac patients.

Through Anderson's company, Nexpep, based in Ivanhoe, Australia, the researchers are also conducting phase I clinical trials on a drug based on the three gluten protein fragments they identified. The aim of the drug is to desensitize celiac patients to the offending proteins by presenting them in very controlled amounts. They expect results within the next couple of months.

The current study received funding from Nexpep, the Australian National Health and Medical Research Council, Coeliac UK, the Coeliac Research Fund, and others.

More information

Find out more about celiac disease at the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.

SOURCES: Robert Anderson, Ph.D., head, celiac disease research laboratory, Walter and Eliza Hall Institute, Parkville, Australia; Alessio Fasano, M.D., professor of pediatrics, medicine, and physiology and director of the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore; July 21, 2010, Science Translational Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Puts Partial Hold on Avandia Safety Study
2. Not Every ACL Tear Needs Early Surgery, Study Suggests
3. Most men in long-term study of HIV report low use of illicit drugs
4. Gladstone and Lundbeck collaborate to study neurovascular disease
5. New Study Finds HPV Vaccine Protects Against Genital Warts
6. Vaginal Gel Cuts Risk of HIV Infection, Study Shows
7. Research consortium at CHLA receives $410,000 to study leukemia and lymphoma
8. Concordia researcher leads study that finds kids reduce physical activity for heart patients
9. Study Suggests Higher Cancer Rate Among IVF Babies
10. HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study
11. Anthony S. Fauci, M.D., on results from the CAPRISA 004 microbicide study
Post Your Comments:
Related Image:
Study Points to Molecular Origins of Celiac Disease
(Date:11/28/2015)... ... ... EST until 11:59 p.m. EST, customers will be racing the clock to ... or more to free gifts with purchases, there will be a new sale available on ... skin care and cosmetic needs, customers will save on already discounted prices. , Top brands ...
(Date:11/27/2015)... ... 2015 , ... There is only one major question facing all law firms ... This question has not been an easy question to answer. Especially when the senior ... younger workforce don’t share the same discipline around working long hours. , In ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... out by the University of Toronto and the University of British Columbia suggested that ... for head injuries. The article explains that part of the reason for the controversial ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the health care in America. As people age, more care is needed, especially ... are rising, and medical professionals are being overworked. The forgotten part of this ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, from Hopkinsville, ... prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. , The ... medications. In doing so, it could help to prevent potential overdose situations. As ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 3D bioprinting market ... to a new report by Grand View Research Inc. Rising ... which demands kidney transplantation is expected to boost the market ... for organ transplantation. --> 3D bioprinting market ... to a new report by Grand View Research Inc. Rising ...
(Date:11/26/2015)... November 26, 2015 ... universitetssjukhus ser potential att använda SyMRI för ... för patienter med multipel skleros (MS) ... med SyntheticMR AB för att kunna använda ... sjukhuset. Med SyMRI kan man generera flera ...
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Italian ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
Breaking Medicine Technology: