Navigation Links
Study Points to Cause of Vioxx Heart Risk
Date:8/27/2007

The drug ups levels of a protein linked to clotting, researchers say

MONDAY, Aug. 27 (HealthDay News) -- Researchers believe they've zeroed in on what caused Vioxx to boost users' heart risks.

The popular pain reliever was taken off the market in 2004 because it was linked to a high risk of heart attack and stroke.

In experiments with mice, the researchers have found that when cox-2 inhibitors like Vioxx block the cox-2 enzyme, it does reduce pain. But it also increases the production of a protein called tissue factor (TF), which can in help initiate unwanted clotting.

Since heart attacks and strokes are triggered by blood clots, it is possible that the overproduction of TF is, in part, responsible for cox-2 inhibitors' dangerous side effects, the University of Connecticut-led team reported in the Aug. 27 online edition of The Journal of Experimental Medicine.

"We provide a mechanism to understand the side effects caused by cox-2 inhibitors," said lead researcher Mallika Ghosh, a post doctorate fellow at the university's Center for Vascular Biology in the department of cell biology at the University of Connecticut Health Center.

Previously, the increased cardiovascular risk associated with cox-2 inhibitors was linked to prostacyclin, another protein important for preventing clotting. It's been shown that cox-2 inhibitors do lower prostacyclin levels.

However, Ghosh's team now proposes an alternate explanation for the added risk.

"We found increased levels of TF in the blood, heart and lungs in mice treated with a cox-2 inhibitor," Ghosh said. "With this mechanism, we can understand why cox-2 inhibitors contribute to the development of cardiovascular events," she said.

The researchers found they could reduce the high levels of TF in cox-2-treated mice by using TF-reducing agents. It may be possible to make cox-2 inhibitors safer by giving TF-blocking drugs
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Gene study links endometriosis, infertility
2. Study reveals how stress can make you sick
3. Study points out that HIV vaccine may not be accepted easily
4. A new study surpasses Gene Therapy Hurdle
5. Tomato Sauce reduces Cancer Risk- Study
6. A question on study of Adult Stem Cell
7. Study on obesity and heart failure
8. National Lung Study in the process
9. Marijuana gateway theory strengthened by study of twins
10. Old theory of adaptation confirmed by new study
11. Study casts doubt on keyboard ills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Jackson, Tennessee (PRWEB) April 27, 2015 A ... to help young people trapped in substance abuse. Programming for ... which will serve girls, is launching this summer. , The ... more than $100,000 to serve adolescents. The Youth Town Jim ... in Collierville on Monday, May 4, with tee times at ...
(Date:4/27/2015)... MD (PRWEB) April 27, 2015 Jesse ... the 2015–2020 United States Pharmacopeial Convention (USP) at the ... is Professor of Medicine at Georgetown University and the ... and Stewardship (COMPASS). , As USP President, a volunteer ... Convention Meeting. He will be a voting member, ex ...
(Date:4/27/2015)... UC Davis investigators have settled a ... inherited disorder that historically affected Ashkenazi Jews from ... populations of Semitic descent, particularly families from Saudi ... the researchers uncovered the biochemical underpinnings of Canavan ... incurable and progressively fatal neurological condition. The UC ...
(Date:4/27/2015)... Based in the Twin Cities of Minneapolis and ... insurance marketing organizations in the country focused on delivering ... as well as employer sponsored ancillary benefits. Spending two ... opportunity to consult with disability insurance carriers, helping to ... , An example of these programs include the most ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 On April 16, ... Get Rid of Stretch Marks ,” interviewed a UK ... . Stretch marks are a type of scar ... are caused by a breakdown of the elsastin and collagen ... (see: goo.gl/iRdmEe) , “Stretch mark removal with the Coolbeam ...
Breaking Medicine News(10 mins):Health News:Golf, Sermon on the Mount and More to Support Youth Town’s Jericho and Eden Programs 2Health News:Dr. Jesse Goodman Elected President of the USP Convention 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 2Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 3Health News:UC Davis Makes Breakthrough in Understanding Canavan Disease 4Health News:Simplified Solutions Now Makes Disability Insurance Business With Secura Consultants Even Easier! 2Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2
... Inc.,(Nasdaq: NXTM ), a leading manufacturer of innovative ... its common stock and,warrants. The private placement consists of ... of $4.50 per share and warrants to purchase 1.9,million ... $5.50 per share,which price may be adjusted to $3.00 ...
... /Xinhua-PRNewswire-FirstCall/ -- Linkwell,Corporation (Linkwell) (OTC Bulletin Board: ... healthcare related disinfectants in China,announced today that ... of China,s,earthquake relief efforts. The Chinese government, ... on an,unprecedented scale in response to the ...
... May 23 Kellogg Company today,announced a $250,000 donation ... efforts in the Sichuan province in southwestern China.,The contribution ... be designated to support the efforts of the Red ... work ahead as people mobilize to rebuild their lives,and ...
... Center (MUMC) now offers a type of gallbladder ... belly button. It,s called single,incision laparoscopic surgery, or ... the SILS technique. One of them is Christopher ... the gallbladder through a,1cm. incision in the belly ...
... from the Peninsula Medical School in Cornwall, UK, have ... topically applied cream with visible light to destroy cancer ... is applied directly to skin cancers and pre-cancers, which ... red light is then shone on the tumour a ...
... Honor, books and DVDs to local schools, SAN ... Medal of Honor Foundation donated 5,000 copies of the,best-selling ... Call of,Duty," to California schools., The book chronicles ... nearly 20 from California, who hold our nation,s,highest award ...
Cached Medicine News:Health News:NxStage Announces $43 Million Private Placement of Equity Securities 2Health News:NxStage Announces $43 Million Private Placement of Equity Securities 3Health News:NxStage Announces $43 Million Private Placement of Equity Securities 4Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 2Health News:Linkwell Corporation Runs 24/7 Disinfectant Operations to Support China's Earthquake Relief Efforts 3Health News:SILS Surgical Technique Now Available at MUMC 2Health News:Let there be light 2Health News:Let there be light 3Health News:TriWest Teaches California Kids About Veteran's Sacrifice, Courage 2
(Date:4/27/2015)... the unique position Massachusetts holds within ... organizations in the New England medtech community, BIOMEDevice Boston ... have partnered to celebrate the region,s medical device industry ... Week. This celebration will take place May 6-7, 2015 at ... Boston . For more information on this event, ...
(Date:4/27/2015)... WOODLANDS, Texas , April 27, 2015   ... biopharmaceutical company focused on developing breakthrough treatments for human ... on Wednesday, April 29, 2015 after the financial markets ... webcast to discuss clinical development progress and financial results ... Time on April 29, 2015. The dial-in ...
(Date:4/27/2015)... YORK , April 27, 2015 Numerous ... in courts around the U.S. have highlighted serious concerns ... Liebhard LLP reports. According to the U.S. Centers ... medications currently on the market have enough information to ... out of 10 expectant mothers in the U.S. take ...
Breaking Medicine Technology:First Annual Massachusetts Medtech Week Celebrated this May 2First Annual Massachusetts Medtech Week Celebrated this May 3Lexicon To Report First Quarter 2015 Financial Results On April 29, 2015 2Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 2Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 3
... 14, 2011  Symmetry Medical Inc. (NYSE: SMA ... orthopaedic device industry and other medical markets, announced today that ... L. Hite, Senior Vice President and Chief Financial Officer, are ... Conference in Boston, MA. Event: ...
... Theramed Corporation ("Theramed") announces that it will ... of the Society of Obstetricians and Gynecologists of Canada. ... used to advance the practice of obstetrics, from Glenveigh ... approved for sale by Health Canada, and Theramed will ...
Cached Medicine Technology:Theramed Corporation to Launch Glenveigh Products, ebb™ and jetty™ at the Society of Obstetricians and Gynecologists of Canada 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: