Navigation Links
Study Offers Clues to Link Between Arrhythmia, Sudden Death
Date:5/8/2008

Uncovering molecular underpinnings could lead to new, genetically targeted therapies

THURSDAY, May 8 (HealthDay News) -- New information about the molecular mechanisms that cause cardiac arrhythmia (irregular heartbeat) and how it triggers sudden cardiac death has been uncovered by Rhode Island Hospital researchers.

They said their findings could lead to the development of new, genetically targeted therapies to treat and prevent fatal arrhythmias. The study was published online Thursday in The Journal of Clinical Investigation.

"We are still struggling to understand why arrhythmia causes sudden cardiac death in some patients, but not others, and what underlying molecular mechanisms or abnormalities may be at play," study senior author Dr. Gideon Koren, director of the cardiovascular research center at Rhode Island Hospital and a professor of medicine at Brown University's medical school, said in a prepared statement.

He and his team developed animal models of long QT syndrome (LQTS) -- a disorder of the heart's electrical system that causes fast, chaotic heartbeats -- to study the various mechanisms that cause arrhythmia. The animal models included the two most common genetic forms of LQTS in humans -- LQT1 and LQT2.

In both forms, faulty genes lead to production of abnormal ion channels, the proteins responsible for moving potassium in and out of heart cells so they can contract. In LQT1, the mutation is in the KvLQT1 gene, while in LQT2, the mutation is in the HERG gene.

The animals with LQT2 exhibited spontaneous arrhythmias, and some of them died suddenly, while there was no spontaneous arrhythmia or sudden death among the animals with LQT1.

The researchers believe that the electrical cause for the deadly arrhythmias in the LQT2 group is increased spatial dispersion of repolarization across the front of the outside layers of cardiac muscle. The LQT1 group did not have increased dispersion.

Koren and his team also believe that HERG and KvLQT1 may interact, and that a mutation of either one of these genes could affect the other.

"While results from animal models are not always applicable to humans, we believe our findings are a first step toward gaining a better understanding of how and why arrhythmias cause sudden cardiac death. However, there is much more that we still don't know," Koren said.

More information

The American Academy of Family Physicians has more about arrhythmia.



-- Robert Preidt



SOURCE: Lifespan, news release, May 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study affirms effectiveness of medication for juvenile rheumatoid arthritis
2. Study identifies molecular response of cartilage to injury
3. Skin flaps deliver cancer-fighting therapy, ASPS study reveals
4. Pilot Study to Assess Safety and Efficacy of Medidur(TM) FA in AMD Patients Treated With Lucentis(R)
5. MIT study suggests caution on new anti-obesity drug in kids
6. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
7. Study in mice suggests molecules in plants have beneficial effect on Alzheimers disease
8. Women and heart attack: Study finds failure to recognize symptoms, failure to treat appropriately
9. Weill Cornell receives funding to study creation of new elder abuse center
10. Pilot study reinforces use of portable anteroom HEPA filtration
11. Warning: New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... ... ... Republicans in the United States Senate on Thursday released their version ... It differs significantly from the American Health Care Act, which the House passed in ... House will have to take up the Senate version as-is, if it passes. , ...
(Date:6/25/2017)... ... 25, 2017 , ... With a heatwave currently bearing down on Northern California pushing temperatures to ... Being swimsuit ready is easy with laser hair removal. , The process of summer ... burdensome routine when all you want to do is get out, dive in and cool ...
(Date:6/24/2017)... PA (PRWEB) , ... June 24, 2017 , ... ... held in Erie, PA at the Sheraton Erie Bayfront and Erie Convention Center ... evidence based medicine experience, exhibits, a student quiz bowl, award and scholarship presentations, ...
(Date:6/24/2017)... (PRWEB) , ... June 24, 2017 , ... Doorknobs are ... home security, such as getting a guard dog or having an alarm system installed. ... aren’t secure against forced entry. Yair Frenkel, owner of TX Premier Locksmith in Killeen, ...
(Date:6/23/2017)... , ... June 23, 2017 , ... By scoring 100% ... ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work ... 1% of all charities reviewed by Charity Navigator and earns ANRF a spot on ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... 16, 2017 Datascope Corp. is voluntarily performing a worldwide field ... potential electrical test failure code.     ... PART NUMBER ... IABP 0998-UC-0446HXX; 0998-UC-0479HXX ... This field correction also ...
(Date:6/14/2017)... N.C. , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away ... reality platform is described by Forbes as "entering the ... American Medical Association as teaching "empathy to medical professionals ... the startup was recently named a finalist for the ...
(Date:6/10/2017)... BESSEMER, Ala. , June 9, 2017  Shane K. Burchfield, ... Member recognized for excellence as a Podiatrist in Alabama ... of Podiatry at Family First Foot Care. He brings over 20 ... sports medicine, pain management and healthcare, to his role. ... Family First Foot Care, PC is pleased to welcome ...
Breaking Medicine Technology: