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Study Measures Real-World Comparative Effectiveness of Asthma Controller Medications
Date:7/8/2008

ific steering committee consisting of individuals recommended by the American Academy of Family Physicians, the American Academy of Pediatrics and the American Association of Allergy and Immunology.

Study researchers found that among patients on a one-drug controller regimen, oral asthma controller medications offered better clinical outcomes for some members, attributable to improved patient compliance on these medications compared to inhaled asthma medications. When compliance with medication was not controlled, patients in the oral asthma controller group were less likely to have inpatient and emergency room visits (odds ratio (OR) =0.80; range: 0.72-0.88), and less likely to use .6 rescue medication inhalers (OR=0.81; range: 0.74-0.88) than those in the inhaled medication group.

Both oral and inhaled treatments offered comparable impact on patient-reported quality of life and productivity. Among patients taking more than one drug to control their asthma, researchers found that a combination of inhaled corticosteroids and long-acting beta-agonists was the best course of treatment in terms of improved outcomes and improved quality of life.

"HealthCore's data provided real-world evidence that patient compliance plays a major role in the overall effectiveness of asthma controller medications, with oral asthma controllers showing better compliance overall than asthma corticosteroid inhalants," said Brian Sweet, chief clinical pharmacy officer, WellPoint, Inc. "In the case of a chronically managed disease, like asthma, where a patient takes medication daily, HealthCore's ability to measure efficacy in the real world enables us to make more informed formulary decisions."

HealthCore, a subsidiary of WellPoint, is a health outcomes and clinical research organization that has served the needs of health plans, government agencies, physician practices and pharmaceutical manufacturers since 1996. HealthCore focuses on providing evidence of the rea
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SOURCE WellPoint, Inc.
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