Navigation Links
Study Links Sugar Production in Yeast Cells to Longevity
Date:3/27/2009

Conservation of glucose for survival may apply to humans as well, researchers say

FRIDAY, March 27 (HealthDay News) -- The process by which yeast cells produce glucose may affect how long the cells -- and perhaps humans -- live, a new study has found.

The researchers found that the chemical process of acetylation, which is key to glucose production, influences yeast cell life and that this process depends on NuA4, an enzyme complex that plays a role in DNA repair.

Acetylation occurs when an acetyl group -- a molecule that is made of oxygen, carbon and hydrogen atoms -- bonds to another compound.

Genetically mutated yeast cells in which the acetylation process was always occurring lived up to 20 percent longer than normal yeast cells, the researchers found. Cells in which the acetylation process was shut off had their life span slashed by 80 percent, the study discovered.

The team, led by researchers from Johns Hopkins University School of Medicine, found the tie to NuA4 in a meticulous process that studied thousands of yeast proteins to see which had an acetyl group stuck to them after NuA4 was added. During their work, the researchers also found that acetylation affects the enzyme Pck1p, another vital cog in how sugar is produced in yeast and, possibly, in human cells as well.

Pck1p, in turn, is also under the direction of Sir2, another enzyme that removes the acetyl group and which other studies have strongly link to the aging process and several diseases in mammals.

"Because the NuA4 complex is highly conserved among species, what we've found in yeast translates to humans as well," researcher Heng Zhu, a Johns Hopkins assistant professor of pharmacology and molecular sciences, said in a Hopkins news release. "What we've revealed about longevity in yeast perhaps someday can translate to human health."

The findings were published in the March 20 issue of Cell.

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Johns Hopkins Medicine, news release, March 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Links Sugar Production in Yeast Cells to Longevity
(Date:3/23/2017)... ... March 23, 2017 , ... ... software solution, iCode Assurance, at HCCA’s 21st annual Compliance Institute on March 26-28 ... coding audit process for all medical chart types with a comprehensive set of ...
(Date:3/23/2017)... ... ... Journey Through Heaven”: the true-life account of a man who faced death and emerged ... for His people. “My Journey Through Heaven” is the creation of published author Earl ... grandchildren living and doing for God as best they can. , Published by Christian ...
(Date:3/23/2017)... ... ... simple and strong explanation of the God’s love. “More Corruption” is the creation of published ... to write a book about Him. , She says, “I’m fed up with mortals misjudging ... Lord God. They have not walked in my shoes and I know they never could ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, the ... and consumer health products, today announced that it had won the ‘Clinical Supply ... the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was presented ...
(Date:3/22/2017)... ... , ... Old School Labs™, makers of the best-selling Vintage line of natural ... Theophane, who trained with Floyd Mayweather, made his professional debut in London in 2003 ... impressive number of wins in contests in Britain, Germany and the U.S. , ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... Sweden , Mar 23, 2017 ... medicine company, today announced that the English version of the ... website www.neurovive.com .  ... About NeuroVive NeuroVive Pharmaceutical AB ... to the discovery and development of medicines that preserve mitochondrial ...
(Date:3/22/2017)... DUBLIN , Mar. 22, 2017 Research ... Care Devices Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 10.9% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... 22, 2017 Under the impetus of ... market size increased year by year at the ... 2021, the market size will maintain the growth ... outnumber RMB140 billion in 2021, thanks to severe ... of biological agents and supporting policies. At ...
Breaking Medicine Technology: