Navigation Links
Study Links Sugar Production in Yeast Cells to Longevity
Date:3/27/2009

Conservation of glucose for survival may apply to humans as well, researchers say

FRIDAY, March 27 (HealthDay News) -- The process by which yeast cells produce glucose may affect how long the cells -- and perhaps humans -- live, a new study has found.

The researchers found that the chemical process of acetylation, which is key to glucose production, influences yeast cell life and that this process depends on NuA4, an enzyme complex that plays a role in DNA repair.

Acetylation occurs when an acetyl group -- a molecule that is made of oxygen, carbon and hydrogen atoms -- bonds to another compound.

Genetically mutated yeast cells in which the acetylation process was always occurring lived up to 20 percent longer than normal yeast cells, the researchers found. Cells in which the acetylation process was shut off had their life span slashed by 80 percent, the study discovered.

The team, led by researchers from Johns Hopkins University School of Medicine, found the tie to NuA4 in a meticulous process that studied thousands of yeast proteins to see which had an acetyl group stuck to them after NuA4 was added. During their work, the researchers also found that acetylation affects the enzyme Pck1p, another vital cog in how sugar is produced in yeast and, possibly, in human cells as well.

Pck1p, in turn, is also under the direction of Sir2, another enzyme that removes the acetyl group and which other studies have strongly link to the aging process and several diseases in mammals.

"Because the NuA4 complex is highly conserved among species, what we've found in yeast translates to humans as well," researcher Heng Zhu, a Johns Hopkins assistant professor of pharmacology and molecular sciences, said in a Hopkins news release. "What we've revealed about longevity in yeast perhaps someday can translate to human health."

The findings were published in the March 20 issue of Cell.

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Johns Hopkins Medicine, news release, March 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Links Sugar Production in Yeast Cells to Longevity
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology: