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Study Links Obesity to Greater Pain, Weakness in Fibromyalgia Patients
Date:1/6/2011

By Maureen Salamon
HealthDay Reporter

THURSDAY, Jan. 6 (HealthDay News) -- Obese fibromyalgia patients suffer more severe symptoms such as pain, reduced flexibility and sleep disturbances than those of normal weight, a new study indicates.

But the good news is that losing weight may bring a modicum of relief, other research suggests.

Noting that pain issues are common in obese people, researchers from the University of Utah analyzed 215 patients with fibromyalgia, a chronic musculoskeletal pain disorder afflicting between 3 percent and 5 percent of Americans, most of them women.

Nearly half of the study participants were obese, and another 30 percent were overweight, with the obese patients experiencing much greater pain to the touch in lower body areas, according to the research. One of the cardinal features of fibromyalgia is extreme pain upon palpation of at least 11 of 18 so-called tender points across the body.

The obese fibromyalgia patients were also more likely than the other study participants to have reduced physical strength, less flexibility in the lower body, a shorter sleeptime and greater restlessness when they did sleep, the study found.

Study author Akiko Okifuji, a professor of anesthesiology at the University of Utah's Pain Research and Management Center, said several effects of obesity on the body may heighten fibromyalgia pain, including increased loading on joints and bones.

"Both fibromyalgia and obesity are clearly big public health concerns. Both conditions seriously impact quality of life," Okifuji said. "It's very difficult to do effective weight management.if you have fibromyalgia. Clearly, if you can do effective weight management, it's better for your overall health."

Obesity is quite common among those with fibromyalgia, with previous research reporting that up to 50 percent of patients are obese and another 21 percent to 28 percent are overweight.

The study, reported in the December 2010 issue of The Journal of Pain, said the poorer sleep quality affecting obese fibromyalgia patients appears to contribute significantly to their fatigue and pain. Obesity is also a risk factor for shorter sleep duration in the general population, according to the study.

Study participants had suffered from fibromyalgia for an average of 12.7 years and were an average of 45 years old, with a mean weight of 184 pounds. Only 47 of the 215 patients had body-mass indexes (BMIs) in the normal range, with four below normal.

In addition to a tender point exam, the participants underwent a home sleep assessment and physical performance tests that included treadmill walking, leg raises, standing push-ups and range-of-motion flexes.

Vitaly Napadow, an assistant professor of radiology at Harvard Medical School who was not connected to the study, said the link between obesity and greater pain in fibromyalgia creates a "vicious cycle" because the pain poses a barrier to exercise, which could reduce weight.

"I think the study was interesting in that it was a larger sample size than the authors studied in the past," said Napadow, also an assistant in neuroscience at Massachusetts General Hospital. "It needs to be recognized that there are these subpopulations in fibromyalgia, and obesity is another burden that needs to be dealt with."

Okifuji said study participants were not asked which condition they had developed first, obesity or fibromyalgia, but noted that each one is a risk factor for the other. Researchers also noted that the study did not determine causality and that its definition of obesity was based on the BMI, which doesn't take into account age or ethnic differences.

"I think the study ended up bringing up more questions than answers," she said.

Both Okifuji and Napadow said a multi-pronged approach to treating obese fibromyalgia patients, including medication, proper nutrition and exercise, needs to be incorporated to maximize symptom relief. Other research has suggested that weight loss may bring some relief from fibromyalgia symptoms, the researchers noted.

"If they're not able to walk because of pain, (perhaps) we can devise upper-body exercise regimens . . . that are not difficult for them to do," Napadow said. "That's one kind of intriguing possibility."

More information

To learn more about fibromyalgia, visit the U.S. National Library of Medicine.

SOURCES: Akiko Okifuji, Ph.D., professor of anesthesiology, Pain Research and Management Center, University of Utah, Salt Lake City; Vitaly Napadow, Ph.D., assistant professor of radiology, Harvard Medical School, and assistant in neuroscience, Massachusetts General Hospital, Boston; December 2010 The Journal of Pain


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