Navigation Links
Study Links Epilepsy Drug in Pregnancy to Lower IQ
Date:1/23/2013

WEDNESDAY, Jan. 23 (HealthDay News) -- Children of mothers who take the antiepileptic drug valproate during pregnancy have lower IQ scores at age 6, a new study says.

And the higher the dose of valproate during pregnancy, the greater the effect on a child's IQ, according to the report published in the Jan. 22 issue of The Lancet Neurology.

For the study, the researchers looked at 305 pregnant women in the United States and United Kingdom who took a single drug to treat the seizure disorder -- either valproate (Depakote), carbamazepine (Tegretol), lamotrigine (Lamictal) or phenytoin (Dilantin).

At age 6, the IQ of children whose mothers took valproate during pregnancy was seven to 10 points lower than children whose mothers took another antiepileptic drug. Exposure to valproate was also associated with poorer speaking and memory abilities.

"These results build on our earlier work to show that valproate usage during pregnancy has a significant negative effect on children's IQ, which lasts beyond their earliest years," said study leader Kimford Meador, a professor in the neurology department at Emory University in Atlanta.

"IQ at age 6 is strongly predictive of adult IQ and school performance, so our research suggests that valproate use during pregnancy is likely to have long-term negative effects on a child's IQ and other cognitive [mental] abilities," Meador added in a journal news release.

Another expert said the study is practice-changing.

"This important work has changed the way we practice neurology, leading us to conclude that valproate should not be used, if at all possible, in women of child-bearing potential," said Dr. Cynthia Harden, chief of the division of epilepsy and electroencephalography at the Cushing Neuroscience Institute in Manhasset, N.Y.

"The risks of valproate during pregnancy are clearly demonstrated, as the children in this research cohort continue to grow," said Harden.

However, the researchers also found that over time IQ may improve for children exposed to valproate in the womb, and that folic acid supplementation in mothers-to-be may improve children's IQ scores.

Harden called the finding about folic acid's mitigating effect "reassuring and fascinating, since the mechanism of how intrauterine valproate exposure causes cognitive [thinking] and behavioral problems in children is unknown."

For some patients, valproate is the only drug that can control their seizures. This may give particular importance to the findings that higher drug doses have a greater impact on IQ and that folic acid supplementation may have a positive effect on IQ, the researchers said.

Meador said more research in this area is urgently needed, given that many women with epilepsy do not have the option of stopping medication during pregnancy.

After a 2009 study found that taking valproate during pregnancy affected children's IQ at age 3, the U.S. Food and Drug Administration issued a warning that valproate exposure in the womb is associated with impaired mental function in children.

More information

The Epilepsy Foundation has more about pregnancy and epilepsy medications.

-- Robert Preidt

SOURCES: Cynthia Harden, M.D., chief, division of epilepsy and electroencephalography, Cushing Neuroscience Institute, North Shore-LIJ Health System, Manhasset, N.Y.; The Lancet Neurology, news release, Jan. 22, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
2. Study shows high blood calcium levels may indicate ovarian cancer
3. New study reveals sex to be pleasurable with or without use of a condom or lubricant
4. Moffitt study shows smoking cessation more successful for cancer patients who quit before surgery
5. Many Suffer Chronic Pain After Breast Cancer Surgery, Study Finds
6. New study examines on/off relationships and sex with an ex among teenagers and young adults
7. Children with egg allergies can safely receive flu vaccine, U-M study says
8. Immune cells engineered in lab to resist HIV infection, Stanford study shows
9. Study explores whether sleeping pills reduce insomniacs suicidal thoughts
10. Study Finds Older Male Scientists Likelier to Commit Research Fraud
11. Study suggests increased diagnosis rate of attention-deficit/hyperactivity disorder at health plan
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Links Epilepsy Drug in Pregnancy to Lower IQ
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified ... series of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve ... The series, known as “Mindfulness for Actors and Artists,” has been featured in ...
(Date:2/10/2016)... , ... February 10, 2016 , ... LaserShip, a regional ... to the Food Bank of Eastern Michigan last Friday in order to aid in ... into the Midwest to include a facility located in Clio, only 15 miles away ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... to expand dental health services to the developmentally disabled in the Coachella Valley. ... operations to a new facility at 71-949 Highway 111, Suite 100-B, in Rancho ...
(Date:2/10/2016)... ... 10, 2016 , ... As part of its ongoing series of aquatic therapy ... webinar features a dynamic expert and thoughtful presentation to give attendees a better sense ... Both events are free to attend, but registration is required. , Rehabilitation ...
(Date:2/10/2016)... ... 10, 2016 , ... Intermedix announced on Wednesday that it ... emergency medicine professional association, to support the organization's newly established physician group with ... Emergency Medicine, or AAEM, seeks to empower emergency physicians to control their own ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... a major "team investment" by Bruce Montgomery , one of this area,s most prominent biotech ... Leen Kawas , PhD. Photo - ... ... ... Kawas said the round was intended to be an $8 ...
(Date:2/11/2016)... , Feb. 11, 2016  AcelRx Pharmaceuticals, Inc. ... presentation will be made at the 38th annual ... Wound Care Symposium, which is being held February 14-18, ... conference covers the latest advancements in wound healing, burn ... American Burn Association, Australian-New Zealand Burns Association, Academy of ...
(Date:2/11/2016)... TEL AVIV, Israel , Feb. 11, 2016  Galmed ... clinical-stage biopharmaceutical company focused on the development of a ... announced today that its Chief Medical Officer, Dr. ... retiring from Galmed as Chief Medical Officer and from ... 2016 due to her reaching retirement age. ...
Breaking Medicine Technology: