Navigation Links
Study Links Cancerous Tumors With Depression

Research with rats finds biological tie between growths and mood changes

WEDNESDAY, May 20 (HealthDay News) -- Doctors have long known that people with cancer often suffer from depression.

A new study in rats has found that the cause of the depression may be the properties of the tumor itself, rather than emotional distress over the diagnosis or side effects from chemotherapy.

The study is the first to identify a biological link between tumors and negative mood changes, according to the researchers, who published their study in the May 18 issue of the Proceedings of the National Academy of Sciences.

About 15 percent to 20 percent of patients diagnosed with cancer experience depression, according to the U.S. National Cancer Institute.

Researchers put about 100 rats through a series of exercises commonly used by researchers testing antidepressants in animal models. Some of the rats had cancerous tumors.

The investigators found that the rats with tumors were less motivated to escape when submitted to a swimming test, a condition that is similar to depression in humans. The rats with tumors also were less eager to drink sugar water, a substance that healthy rats usually find irresistible.

"In this case, examining behavioral responses to tumors in non-human animals is particularly useful, because the rats have no awareness of the disease, and thus their behavioral changes were likely the result of purely biological factors," said senior study author Brian Prendergast, associate professor of psychology at the University of Chicago.

The team determined that substances associated with depression are produced in increased quantities by tumors and are transmitted to the brain.

Additionally, pathways that normally moderate the impact of depression-causing substances are disrupted when a tumor develops.

Tumors induce changes in gene expression in the hippocampus, the portion of the brain that regulates emotion.

Rats with tumors had increased levels of cytokines in their blood and in the hippocampus when compared with healthy rats. Previous research has linked high levels of cytokines, which are produced by the immune system, to depression.

The research team also found that stress hormone production was altered in rats with tumors.

The rats with tumors had dampened production of the stress hormone corticosterone, which helps regulate the impact of cytokines. Reducing the production of corticosterone may increase the impact of cytokines.

"Our research shows that two types of tumor-induced molecules, one secreted by the immune system and another by the stress axis, may be responsible," said Leah Pyter, a postdoctoral fellow at the University of Chicago and lead study author. "Both of these substances have been implicated in depression, but neither has been examined over time frames and magnitudes that are characteristic of chronic diseases such as cancer."

More information

The U.S. National Cancer Institute has more on cancer and depression.

-- Jennifer Thomas

SOURCE: University of Chicago, news release, May 18, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New Study Reveals Wide Variations in Depression Diagnoses among Ethnic Groups
2. HIMSS Analytics and NetMotion Wireless Release Study Findings on Key Challenges for Wireless Healthcare Deployments
3. Stem Cell Study Offers Hope for Targeting Tumors
4. Study Reiterates Eye Risks Linked to Flomax
5. Study Shows NeuroStar TMS Therapy(R) Improved Key Elements of Cognition in Patients with Major Depressive Disorder
6. BioHorizons Reports on Comparative 3-Year Dental Implant Study Showing Significant Crestal Bone and Soft Tissue Retention Using Laser-Lok(R) Microchannels
7. Results of phase III study on Labopharms novel antidepressant published in Psychiatry (Edgemont) Journal
8. SYNTAX Substudy Shows Positive Outcomes for Left Main Patients Treated With TAXUS(R) Express2(R) Stent System
9. MS Patients More Compliant with Medications When Managed by Specialty Pharmacy, According to HealthCore Study Presented at ISPOR
10. Deloitte Comparative Effectiveness Study Evaluates Potential Savings Opportunities for U.S. Health Care System
11. Workplace E-Mail Intervention Program Helps People Sit Less and Eat Better, Kaiser Permanente Study Finds
Post Your Comments:
Related Image:
Study Links Cancerous Tumors With Depression
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
Breaking Medicine Technology: