Navigation Links
Study IDs new cause of brain bleeding immediately after stroke
Date:4/17/2014

Irvine, Calif., April 17, 2014 By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.

A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.

Dritan Agalliu, assistant professor of developmental & cell biology at UC Irvine, and Axel Nimmerjahn of the Salk Institute for Biological Studies developed a novel transgenic mouse strain in which they use a fluorescent tag to see the tight, barrier-forming junctions between the cells that make up blood vessels in the central nervous system. This allows them to perceive dynamic changes in the barrier during and after strokes in living animals.

While observing that barrier function is rapidly impaired after a stroke (within six hours), they unexpectedly found that this early barrier failure is not due to the breakdown of tight junctions between blood vessel cells, as had previously been suspected. In fact, junction deterioration did not occur until two days after the event.

Instead, the scientists reported dramatic increases in carrier proteins called serum albumin flowing directly into brain tissue. These proteins travel through the cells composing blood vessels endothelial cells via a specialized transport system that normally operates only in non-brain vessels or immature vessels within the central nervous system. The researchers' work indicates that this transport system underlies the initial failure of the barrier, permitting entry of blood material into the brain immediately after a stroke (within six hours).

"These findings suggest new therapeutic directions aimed at regulating flow through endothelial cells in the barrier after a stroke occurs," Agalliu said, "and any such therapies have the potential to reduce or prevent stroke-induced damage in the brain."

His team is currently using genetic techniques to block degradation of the tight junctions between endothelial cells in mice and examining the effect on stroke progression. Early post-stroke control of this specialized transport system identified by the Agalliu and Nimmerjahn labs may spur the discovery of imaging methods or biomarkers in humans to detect strokes as early as possible and thereby minimize damage.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum
2. Celldexs Phase 1 study of CDX-1401 published in Science Translational Medicine
3. Study links severe sleep apnea to increased risk of stroke, cancer and death
4. Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS
5. UT Dallas study: Youth who fail to envision future commit more crimes
6. Study identifies a likely key driver of colorectal cancer development and progression
7. Study gives high marks to NC Pre-K program
8. Proteomics International biomarker study closer to a CDx test for diabetic kidney disease
9. Study links domestic abuse to mental health problems in new mothers
10. Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds
11. Lipid levels during prenatal brain development impact autism: York U study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... ... “To Walk Away”: a captivating and romantic sequel to the romantic story of ... the creation of published author, Larry R. Sherman, a retired chemistry professor from the ... as well as four novels. , Though the book opens in 1947, when ...
(Date:8/22/2017)... Carolina (PRWEB) , ... August 22, 2017 , ... ... advisor. Mr. Stewart is the Founder and Managing Member for t4 Leadership Development ... have become critical to his definition of “success”: physician leadership development, servant leadership, ...
(Date:8/21/2017)... ... August 22, 2017 , ... Nanoparticle research provides an ... safety. By learning and implementing best practices for containment using ventilated safety enclosures, ... will gain a better understanding of a method for safely testing nanotechnology hoods. ...
(Date:8/21/2017)... ... August 21, 2017 , ... Five chefs from local senior assisted living ... Center. , Guests will be able to vote for their favorite Chef among ... with Fennel Dill Salad, Feta Cheese Sauce & Garlic Pita Crisp, Greek Mountain Ice ...
(Date:8/21/2017)... ... ... The American Hospital Association (AHA) has elected Claire Zangerle, Chief Nurse Executive ... of Trustees for a three-year term beginning January 1, 2018. , The ... are committed to the improvement of health in their communities. Founded in 1898, the ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) today announced ... Aug. 7, 2017. ... and will serve as president emeritus during a planned, 90-day ... multiple leadership roles since he joined Diplomat with the acquisition ... decisive, strategic leadership which continues to benefit our patients and ...
(Date:8/7/2017)... 7, 2017  Endo International plc (NASDAQ: ... resolve virtually all known U.S. mesh product liability claims ... the known remaining U.S. claims at reasonable values. Under ... the fourth quarter of 2017 and continuing through the ... quarter 2017 results, the Company intends to increase its ...
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
Breaking Medicine Technology: