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Study IDs benefit of donor SCT for adults with acute myeloid leukemia
Date:6/9/2009

eic transplant in first remission proved to be the most effective strategy, the investigators found.

"Allogeneic transplants have been shown to be very effective for many AML patients with aggressive disease, but such transplants are often associated with serious side effects and complications. It has never been comprehensively shown which patients stand to benefit significantly from the procedure," says the study's lead author, John Koreth, MBBS, DPhil, of Dana-Farber. "For patients with poor- and good-risk AML, our study provides reassurance that the current treatment recommendations are correct. Our finding that people with intermediate-risk AML benefit significantly from allogeneic transplant in first remission should establish it as the preferred treatment for this group."

In the study, Koreth and his colleagues analyzed the results of 24 clinical trials involving more than 6,000 AML patients from age 18 to 60. They found that over the long term, patients with poor- and intermediate-risk AML who received allogeneic stem cell transplants in first clinical remission were more likely to be alive than those who received alternative therapies, and were less likely to suffer disease relapse.

While the findings support the use of chromosome analysis -- the classification of AML cases as either poor-, intermediate-, or good-risk -- for guiding treatment, "There remains a need to further individualize the allogeneic SCT decision, based on factors like patient age, overall health, and other considerations, including newer molecular tests," Koreth says.


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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

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