Navigation Links
Study IDs Variations in Black, White Genomes
Date:3/24/2009

Differences associated with behavioral traits, susceptibility to certain diseases

TUESDAY, March 24 (HealthDay News) -- U.S. researchers have identified 1,362 copy number variations (CNVs) in the human genome of blacks and 1,972 in whites.

CNVs -- differences in gene copy numbers caused by deletions, duplications or rearrangements of genomic regions -- account for a large amount of human diversity and can also be associated with behavioral traits or increased susceptibility to a disease.

Across the genome, there was little difference in the frequency of CNVs between blacks and whites. However, there was a marked difference in the frequency of two duplications, one on chromosome 15 and another on chromosome 17, said Joseph P. McElroy and his colleagues in the neurology department at the University of California, San Francisco.

A duplication in chromosome 17 (region 17q21) was found in 45 percent of the 435 whites in the study and in 8 percent of the 435 blacks. This region has been implicated in mental retardation caused by the deletion of two genes due to duplication. The two genes aren't located within the 17q21 region, but are very close to it, the researchers said.

"It would be good to know if the CNV duplication of the region might have an effect on the expression of these genes, which in turn could result in neurological disease. It is also interesting to find out whether the type of mental retardation associated with this locus is more common in whites than in Africans or African-Americans. If this is true, then it might be one of the first reported diseases with differing ethnic frequencies due to CNVs," McElroy said in a news release.

The study was published March 23 in the journal BMC Genetics.

"To the best of our knowledge, this is the first detailed map of copy number variations in African-Americans. Understanding the distribution of CNVs in a population is a first step to addressing their role in disease," McElroy said.

More information

The U.S. National Institute of General Medical Sciences has more about human genetic variation.



-- Robert Preidt



SOURCE: BioMed Central, news release, March 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers studying hearing loss find auditory regions of the brain convert to the sense of touch
2. Pilot Study Using Video Cell Phones for Mobile Direct Observation Treatment (MDOT) to Monitor Medication Compliance of TB Patients
3. Study shows how Salmonella survives in environment
4. Study IDs Gene Variants Tied to Sudden Cardiac Death
5. Transition Therapeutics Announces Initiation of a Phase Ib Clinical Study of TT-223 in combination with a GLP-1 analogue in Patients with Type 2 Diabetes
6. New Clinical Study News for Treatment of Sinusitis, Sinus Infection and Allergy Sufferers Now Have a New Effective Form of Relief through Sinus Dynamics
7. Study quantifies racial disparities in cancer mortality rates between blacks and whites
8. Herbalife Protein Shake Proven Effective in Clinical Study
9. New study finds daily drinking is biggest risk factor in serious liver disease
10. Mayo Clinic Study Suggests Those Who Have Chronic Pain May Need to Assess Vitamin D Status
11. Mayo Clinic study suggests those who have chronic pain may need to assess vitamin D status
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study IDs Variations in Black, White Genomes
(Date:1/20/2017)... ... January 20, 2017 , ... "TransFlare 4K Mystique comes with ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... the Dragon Sensor,TransFlare 4K Mystique lens flare and light leak transitions have a very ...
(Date:1/20/2017)... ... ... “Mary Magdalene: Grace is Greater than Sin”: a unique and memorable ... firsthand. “Mary Magdalene: Grace is Greater than Sin” is the creation of published author, ... countless women who had little knowledge of the female characters portrayed in the Holy ...
(Date:1/20/2017)... ... , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on to ... published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of 5, ... years of age, he joined the Navy and got married right out of boot camp. ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... ... vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a study ... Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure ...
(Date:1/20/2017)... ... ... “Journey to Christmas:” a beautiful and enchanting tale that teaches children the true meaning of ... three in Oklahoma City, and a devoted woman of faith. , “Becoming a parent ... the back of my mind for years, but actually doing it might have been a ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 Many patients ... for their medication when a pharmacy just a few ... prescription.  To alleviate this problem Medicationdiscountcard.com has ... to see exactly how much their medication will cost ... Made Easy Medicationdiscountcard.com ...
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin Receptor Agonists, Sympathomimetic-GABA ... drugs market is expected to grow at a CAGR of ... of 38.7% in the second half of the forecast period. The ... 2016 to 2027. The market is estimated at $1,058 million in ... ...
(Date:1/19/2017)... 2017 Accuray Incorporated (Nasdaq: ARAY ... continue to set the bar for excellence in customer ... user satisfaction rating among radiation treatment delivery systems in ... Market Intelligence Briefing™. The most recent ratings trend also ... industry peers for 11 of the past 12 quarters. ...
Breaking Medicine Technology: