Navigation Links
Study IDs Gene for Late-Onset Alzheimer's
Date:5/28/2008

Finding could lead to more effective drugs to slow progression of disease

WEDNESDAY, May 28 (HealthDay News) -- A gene that plays a role in Alzheimer's disease in two large families in which many siblings suffer from the neurodegenerative condition has been identified by U.S. researchers.

Identification of this gene -- TRPC4AP on chromosome 20 -- opens a new line of research that may help improve understanding of what causes Alzheimer's disease.

TRPC4AP is involved in calcium regulation. It's known that when calcium levels aren't carefully controlled, cells can die, leading to the onset of disease.

In this study, researchers at the Medical College of Georgia and the VA Medical Center in Augusta focused on two large families with a history of late-onset Alzheimer's disease who were enrolled in a DNA bank. Both families had 15 siblings, five of whom had Alzheimer's. Analysis of blood samples revealed that all the patients in both families had the same pattern of single nucleotide polymorphisms (SNPs), which are single base changes in gene structure found throughout DNA.

When they analyzed samples from other Alzheimer's patients in the DNA bank, the researchers found that 36 percent had the same pattern of SNPs as the patients in the two families.

The study was published in the current issue of the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

"The use of extended pedigrees is vital for genetic studies. The next step will be to identify the exact mutation in this gene which is causing the disease. The DNA is currently being sequenced to find this mutation," study author Dr. Shirley Poduslo said in a prepared statement.

"The long-term significance will be to understand the mechanism of the disease so that more effective drugs can be designed to slow the progression of the disease, delay the onset, identify patients early in the disease course and, hopefully, someday to keep this dreadful disease from occurring," Poduslo said.

More information

The National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Blackwell Publishing, news release, May 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study: Child maltreatment victims lose 2 years of quality of life
2. New study shows sedentary high school girls are at significant risk for future osteoporosis
3. $1.3M NIH grant to fund Parkinsons disease study
4. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
5. New Study of Bush Medicare Cuts: Texas Rural Seniors, Nursing Homes 2nd Hardest Hit in Nation
6. Research Study Shows That Pharmaceutical Field Sales Reps Productivity Inhibited by Unnecessary Internal Communication
7. Study shows pine bark naturally reduces cardiovascular risk factors in diabetics
8. New study reveals brain cell mechanism of alcohol dependence
9. Looking Tired or Angry May Have More to do With Facial Aesthetics Than How You Feel, ASPS Study Reveals
10. Study Shows Pine Bark Naturally Reduces Cardiovascular Risk Factors in Diabetics
11. Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... ... 2017 , ... On Saturday, October 21, the Health & Wellness Center at ... raise money for the American Heart Association Heart Walk. Teams of up to 10 ... to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
Breaking Medicine Technology: