Navigation Links
Study IDs Gene for Late-Onset Alzheimer's
Date:5/28/2008

Finding could lead to more effective drugs to slow progression of disease

WEDNESDAY, May 28 (HealthDay News) -- A gene that plays a role in Alzheimer's disease in two large families in which many siblings suffer from the neurodegenerative condition has been identified by U.S. researchers.

Identification of this gene -- TRPC4AP on chromosome 20 -- opens a new line of research that may help improve understanding of what causes Alzheimer's disease.

TRPC4AP is involved in calcium regulation. It's known that when calcium levels aren't carefully controlled, cells can die, leading to the onset of disease.

In this study, researchers at the Medical College of Georgia and the VA Medical Center in Augusta focused on two large families with a history of late-onset Alzheimer's disease who were enrolled in a DNA bank. Both families had 15 siblings, five of whom had Alzheimer's. Analysis of blood samples revealed that all the patients in both families had the same pattern of single nucleotide polymorphisms (SNPs), which are single base changes in gene structure found throughout DNA.

When they analyzed samples from other Alzheimer's patients in the DNA bank, the researchers found that 36 percent had the same pattern of SNPs as the patients in the two families.

The study was published in the current issue of the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

"The use of extended pedigrees is vital for genetic studies. The next step will be to identify the exact mutation in this gene which is causing the disease. The DNA is currently being sequenced to find this mutation," study author Dr. Shirley Poduslo said in a prepared statement.

"The long-term significance will be to understand the mechanism of the disease so that more effective drugs can be designed to slow the progression of the disease, delay the onset, identify patients early in the disease course an
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Study: Child maltreatment victims lose 2 years of quality of life
2. New study shows sedentary high school girls are at significant risk for future osteoporosis
3. $1.3M NIH grant to fund Parkinsons disease study
4. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
5. New Study of Bush Medicare Cuts: Texas Rural Seniors, Nursing Homes 2nd Hardest Hit in Nation
6. Research Study Shows That Pharmaceutical Field Sales Reps Productivity Inhibited by Unnecessary Internal Communication
7. Study shows pine bark naturally reduces cardiovascular risk factors in diabetics
8. New study reveals brain cell mechanism of alcohol dependence
9. Looking Tired or Angry May Have More to do With Facial Aesthetics Than How You Feel, ASPS Study Reveals
10. Study Shows Pine Bark Naturally Reduces Cardiovascular Risk Factors in Diabetics
11. Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... The festival season is coming soon. The high-end fashion designer ... cocktail dresses . A lot of sophisticated women like its ... new promotion for its high quality clothes. Now, each of ... 20 to 71 percent off. , The company’s cocktail ... provided in many fashionable colors. Mary, the company’s sales manager, ...
(Date:9/20/2014)... September 20, 2014 New PharmaPoint ... Market Analysis to 2023?. The asthma market saw ... it has become saturated with relatively efficacious standard ... (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and ... generic competition. However, the launch of seven novel ...
(Date:9/20/2014)... 20, 2014 iFitDress.com, the popular online ... women, has recently unveiled its new collection of cocktail ... for special offer on these new outfits; it intends ... All customers can now buy cheap cocktail dresses ... sales representative says, “We have extensive experience in the ...
(Date:9/20/2014)... 2014 The excitement is building up once again ... Carolina. This year the Surry Arts Council will be celebrating ... the country who are still fans of the Andy Griffith Show. ... that aired on CBS from 1960 through 1968. The show ... television history. Mount Airy, North Carolina is where the show ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 "As a nurse, ... their tanks," said an inventor from Tamaqua, Pa. "The reason ... on the backs of their chairs. My invention enables them ... the Kam Oxygen Sensor to make it easier to monitor ... the user knows when the tank is low. It allows ...
Breaking Medicine News(10 mins):Health News:High-end Fashion Designer BellasDress Offers Luxurious Cocktail Dresses For Sophisticated Women 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 3Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 4Health News:Fashionable Cocktail Dresses Unveiled Online at iFitDress.com 2Health News:Mayberry Days Parade Cars will be Provided by Mount Airy Toyota and Mount Airy Chrysler Dodge Jeep Ram 2
... imaging developed by researchers at Duke University,s Pratt School ... better than those made with traditional ultrasound, according to ... suggests that the imaging method known as Acoustic Radiation ... for screening patients at increased risk for liver cancers, ...
... Cardiovascular problems surfaced in people with no history of ... People with no history of heart problems who felt ... to heart problems in the three years following the ... trigger an immediate lethal heart attack in some people, ...
... Wellness Solutions DVD Series Offer Integrative Health ... Solutions for Ten Chronic Medical Conditions, BROOMFIELD, Colo., Jan. ... with more than 46,percent of the fitness and wellness market, ... of DVDs focused on providing,integrative health solutions for ten chronic ...
... SAN DIEGO, Jan. 7 Calorie-conscious, health-minded,Americans ... new ally to support them in following,through ... nutrition information about healthier choices at a ... restaurants from fast food to,upscale dining establishments ...
... / Cariani /,Lindsay, a leading, national executive and board ... Partner. She will be based in the,Firm,s Los Angeles ... sectors., Prior to joining HNCL Search, Vicky was ... Before Warner Bros., she,spent six years at Heidrick & ...
... The Columbia Center for Childrens Environmental Health (CCCEH) ... has received a $10.4 million grant from the ... study environmental contributors to childhood asthma. The ... called Disease Investigation through Specialized Clinically-Oriented Ventures in ...
Cached Medicine News:Health News:High-energy ultrasound sharpens view of liver tumors 2Health News:High Levels of Stress After 9/11 Raised Heart Disease Risk 2Health News:High Levels of Stress After 9/11 Raised Heart Disease Risk 3Health News:Gaiam Inc., The Leader in Innovative Lifestyle Solutions, Announces New DVD Series Created with Mayo Clinic 2Health News:Gaiam Inc., The Leader in Innovative Lifestyle Solutions, Announces New DVD Series Created with Mayo Clinic 3Health News:Online Resource Keeps Restaurant Diners on Track After New Year's Hype Subsides 2Health News:Vicky Goldberg Joins Executive and Board Search Firm Hodge / Niederer / Cariani / Lindsay 2Health News:Columbia Center for Children's Environmental Health receives NIEHS grant to study asthma 2Health News:Columbia Center for Children's Environmental Health receives NIEHS grant to study asthma 3Health News:Columbia Center for Children's Environmental Health receives NIEHS grant to study asthma 4
(Date:9/19/2014)... Sept. 19, 2014 A pharmaceutical executive in ... with three issues he wanted the research and consulting ... external personnel (especially for secondary research) to maximize efficiency ... of increased workload , Automation of market research ... , How to implement and manage those automated ...
(Date:9/19/2014)... /PRNewswire-iReach/ -- Market Research Report on Global ... a professional and in-depth market survey on ... report firstly reviews the basic information of ... manufacturing technology. The report then explores global ... listing their product specification, capacity, Production value, ...
(Date:9/19/2014)... Kiromic, LLC, a Lubbock bio-pharmaceutical company, ... former chancellor of Texas Tech University, to its board as ... after raising $1.2 billion for the university. "Kiromic ... most successful chancellor in the history of Texas Tech University, ... but also as our new vice chairman of the board. ...
Breaking Medicine Technology:In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2
The most comfortable and easy to use apron in the industry. This front protection apron comes with a fully adjustable snap-on 5" orthopedic belt to relieve weight off your shoulders. Velcro strap acr...
Unique criss-cross strapping. The MSV-10 is our most popular model. Extra wide Velcro ensures a wide variety of adjustments and easy closing....
Designed to be removed from under surgical gown without compromising sterile fields. Two straps criss-cross in the back and attach with velcro in the front....
Weight is evenly distributed by fully adjustable velcro straps that cross in the back. Adjustable back velcro keeps apron snug....
Medicine Products: