Navigation Links
Study Hints at Link Between Antidepressants and Heart Trouble
Date:4/3/2011

By Steven Reinberg
HealthDay Reporter

SATURDAY, April 2 (HealthDay News) -- Men taking antidepressants may be at risk for atherosclerosis, which can increase the risk of a heart attack or stroke, a small, preliminary study suggests.

Antidepressants were associated with about a 5 percent increase in the thickness of the large artery in the neck called the carotid artery, which carries blood to the brain, the researchers from Emory University found.

Yet experts not involved with the study noted that it did not prove a cause-and-effect relationship between antidepressant use and heart trouble, and added that depression itself can increase the risk of cardiovascular problems.

"Antidepressant medications may decrease cardiovascular risk by treating depression," said Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles.

Since the new findings are very preliminary, Fonarow said, "Patients should not be concerned or stop taking antidepressant medications on the basis of this study."

Results of the research were scheduled to be presented Saturday at the American College of Cardiology's annual scientific session, in New Orleans. Experts note that studies presented at medical conferences do not undergo the same vetting as research published in peer-reviewed journals. The study was funded by the U.S. National Institutes of Health.

For the study, a team led by Dr. Amit Shah, a cardiology fellow at Emory, collected data on 513 middle-aged male twins who were part of the Vietnam Era Twin Registry. Sixteen percent of the men were taking antidepressants, and of these, 60 percent were taking selective serotonin reuptake inhibitors (SSRIs), such as Prozac, Lexapro and Zoloft. The others were taking older antidepressants.

To try to isolate the effect of antidepressants on blood vessels, the researchers measured the thickness of the carotid artery -- called carotid intima-media thickness. The study authors found that a twin taking an antidepressant had a greater intima-media thickness than a brother not taking the drugs.

The finding held true, regardless of the antidepressant taken, the researchers said.

"There is a clear association between increased intima-media thickness and taking an antidepressant, and this trend is even stronger when we look at people who are on these medications and are more depressed," Shah said in a news release from the American College of Cardiology.

"Because we didn't see an association between depression itself and a thickening of the carotid artery, it strengthens the argument that it is more likely the antidepressants than the actual depression that could be behind the association," he added.

The findings also held true after compensating for such factors as age, diabetes, blood pressure, current or previous smoking, cholesterol and weight. Other factors weighed included depressive symptoms, history of major depression and heart disease, alcohol and coffee use, statin use, physical activity, education and employment, the researchers said.

Since each additional year of life is associated with a small increase in intima-media thickness, a brother taking antidepressants is physically 4 years older than the brother not taking antidepressants, Shah's team contended. They also said that even a small increase in intima-media thickness can increase the risk of a heart attack or stroke by 1.8 percent.

It's not clear why there might be an association between antidepressant use and heart disease, the study authors noted. These drugs increase levels of the brain chemicals serotonin and norepinephrine, which are often low in depressed individuals.

Shah said increased levels of these chemicals may cause blood vessels to tighten, and this may lead to reduced blood flow to organs and higher blood pressure, which is a risk factor for atherosclerosis.

Commenting on the study, Dr. Dominique L. Musselman, an associate professor of clinical psychiatry at the University of Miami Miller School of Medicine, underscored that the findings show an association between antidepressant use and atherosclerosis, but not a cause-and-effect relationship.

"This finding is somewhat counterintuitive since it is well known that SSRIs enhance a tendency to bleed," she said, adding that more rigorous studies are needed to see if a cause-and-effect relationship exists.

Musselman also strongly advises patients not to stop taking antidepressants based on this study. Not treating depression can have serious consequences for quality of life, survival after a heart attack or other cardiovascular events, she said.

"This is an important finding that needs to be replicated," she added.

More information

For more on antidepressants, visit the U.S. National Library of Medicine.

SOURCES: Gregg C. Fonarow, M.D., professor, cardiology, University of California, Los Angeles; Dominique L. Musselman, M.D., associate professor of clinical psychiatry, University of Miami Miller School of Medicine; April 2, 2011, presentation, American College of Cardiology annual scientific session, New Orleans


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... ... in Newburgh, New York, has recently begun offering three new minimally invasive procedures ... best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to bring microneedling, ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has ... Dr. Talei has come up with a proprietary technique that he calls the ... that have dropped. For all ages, patients can expect to look refreshed, rejuvenated, and ...
(Date:6/23/2017)... ... 2017 , ... MD Now Urgent Care opened its newest location ... and marks the urgent care center's eighth location in Miami-Dade county. , The center's ... mall. The new clinic offers a wide array of services to patients ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus ... from 9 am to 3 pm to present to graduate students exciting new and ... an original curriculum project led by The Health Improvement Service of the Western Health ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... financial planning to families and business owners in North Central West Virginia, is ... provide services to differently abled residents in the region. , The Stepping Stones ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... , June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: ... call and webcast on Friday, July 28, 2017, beginning at ... Call Audio Only Dial-in information: To participate in the conference ... dial into the call at least 10 minutes prior to ... is 34090339.  Webcast: ...
(Date:6/16/2017)... June 16, 2017  Exactly 50 years ago today, the ... later became known as the San Francisco "Summer of Love."  ... unveiling two radical innovations in strategic market research portals that ... marks the beginning of Northern Light,s "Summer of Love (For ... ...
(Date:6/14/2017)... , June 14, 2017  In 2016, Embodied ... Startups pitch competition and came away with $25,000 ... is described by Forbes as "entering the life of ... Association as teaching "empathy to medical professionals in an ... was recently named a finalist for the Department of ...
Breaking Medicine Technology: