Navigation Links
Study Gives First Evidence That Adult Human Lungs Can Regrow
Date:7/18/2012

By Barbara Bronson Gray
HealthDay Reporter

WEDNESDAY, July 18 (HealthDay News) -- Researchers have uncovered the first evidence that the adult human lung is capable of growing back -- at least in part -- after being surgically removed.

In an observational study, researchers used MRIs with hyperpolarized helium-3 gas to show that existing alveoli -- the tiny, air-exchange units of the lung -- actually increased in number after a 33-year-old woman had her entire right lung removed due to cancer.

The study showed a 64 percent increase in the number of alveoli in the woman's lung 15 years after surgery. "The research clearly shows that some form of lung growth can occur in the adult human," said study author James Butler, an associate professor of medicine in the department of medicine at Harvard Medical School in Boston.

The new alveoli were all shaped similarly. "It's striking, the degree of homogeneity of the new alveoli, as if the lung was responding to something," Butler added. The cause of the new growth could be stretching of the tissue, perhaps by exercise, he suggested. "Could other bio-molecular growth be triggered by stretch? It's a wide-open question now."

About a year and a half after surgery, the woman began a daily exercise program including walking, cycling and yoga. Previous studies in adult dogs have suggested that lung growth after pneumonectomy (removal of the lung) in dogs was possible, typically after periods of lung stress or strain.

Over a period of 15 years, data measuring lung size and capacity were collected, using common respiratory tests (called FEV and FVC) measuring how much air can be taken in and blown out with deep breaths. In the early months after surgery, the lung responded as researchers would expect. The total lung volume increased and the lung density fell below normal. But, the lung tissue volume gradually started to increase and the density returned to a level normally seen when a deep breath is taken, suggesting the growth of new tissue.

The ability of the lung to regenerate, potentially triggered by exercise, makes sense, said Dr. Norman Edelman, a professor of medicine at Stony Brook University and chief medical officer of the American Lung Association. "When the lung develops in utero [when the fetus is developing], the pulling force of the diaphragm is an important stimulation for the lung to grow," he said. "But, of course, the practical application of the research is a long way off."

Butler said the next step is to do a study involving more people over time. "If we can discover the underlying bio-molecular mechanisms, they would suggest potential therapeutic options," he explained.

More information

For more on lung disease, visit the American Lung Association.

SOURCES: James P. Butler, associate professor, medicine, department of medicine, Harvard Medical School, Boston; Norman H. Edelman, M.D., professor, medicine, Stony Brook University, chief medical officer, American Lung Association; July 19, 2012, The New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Gives First Evidence That Adult Human Lungs Can Regrow
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, ... In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the ... have extremely low property-tax rates, which contributes to the relatively lower cost of ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017  PMD ... OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... strategic hub service that expedites and streamlines patient and ... Spiro PD 2.0, and wellness management services.  ... medical device used to measure lung function for a ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
(Date:9/9/2017)... ... ... Monday, September 18 th .The Brain Tumor Foundation (BTF) begins a week-long ... BTF,s Mobile MRI Unit – a 70 Ft. ... brings its nationwide initiative, the Road to Early Detection Sponsor-A-City Campaign to ...
Breaking Medicine Technology: