Navigation Links
Study Finds Potential Cause of Age-Related Macular Degeneration
Date:3/17/2008

Data could lead to new drugs to check vascular proliferation that is hallmark of eye disease

MONDAY, March 17 (HealthDay News) -- Researchers have pinpointed a biological pathway that may block the blood vessel proliferation and leakiness behind most cases of blindness in the United States.

Though still preliminary, the University of Utah study suggests a new therapeutic target for such ophthalmic diseases as age-related macular degeneration (AMD) and diabetic retinopathy, as well as other conditions marked by inflammation and vascular leakiness, including cancer and certain traumatic injuries.

"I think it is very strong science," said Dr. George A. Williams, chairman of the department of ophthalmology at William Beaumont Hospital in Royal Oak, Mich. "It identifies a promising preliminary observation that is going to require a lot more development."

That observation involves a cell surface protein called Roundabout (Robo)-4. Other Robo family members play a role in neuronal growth and guidance, but Robo4 is different, said senior study author Dr. Dean Li, of the University of Utah, "mostly in that it was not expressed in nerves but in blood vessels."

Li has spent five years trying to understand the biology of Robo4. "We have been trying to figure out, why is this protein on blood vessels, and that is what this article answers -- what does this thing do?" he explained.

Li, along with Dr. Kang Zhang, also of the University of Utah, mutated the Robo4 gene in mice. They then characterized the behavior of cells from these mutant mice in response to the growth factor VEGF in the presence and absence of Robo4's binding partner, a protein called Slit2.

Normally, VEGF promotes angiogenesis, inducing vascular cell division, migration and vessel formation via its receptor. VEGF activity is responsible for normal vascular growth, but it also has a dark side, inducing the damage in AMD, diabetic
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Finds Potential Cause of Age-Related Macular Degeneration
(Date:9/2/2015)... Grove, Utah (PRWEB) , ... September 02, 2015 , ... ... in Utah to attend doTERRA’s annual convention, the largest single-company convention to date for ... Wellness Advocates and look forward to a tremendous event,” states David Stirling, doTERRA CEO. ...
(Date:9/2/2015)... ... ... The payroll conference theme this year is "TAKING STEPS ... updates, including unemployment, global payroll best practices, and the latest trends in payroll ... American Payroll Association, Barnett Associates, and the IRS, will keep payroll professionals up ...
(Date:9/2/2015)... Greenville, SC (PRWEB) , ... September 02, 2015 , ... ... P.A., announced today that he is now certified in “Systema”: a Russian martial art ... all aspects of life. , Systema , which dates back to the ...
(Date:9/1/2015)... Spring Lake, NJ (PRWEB) , ... September 01, ... ... physician, has a reputation for the telling the truth about medicine and health, ... has created a video blog, where he plans to regularly debunk certain misconceptions ...
(Date:9/1/2015)... ... September 01, 2015 , ... In an article ... across the country are switching from traditional dental impressions to digital impressions using ... Dr. Sam Saleh of Ora Dentistry Spa, his practice has been an early ...
Breaking Medicine News(10 mins):Health News:doTERRA to Host the Largest Single-Company Convention in the State of Utah 2Health News:23rd Annual NJ Statewide Payroll Conference in Vernon, NJ at the Minerals Hotel on October 15-16, 2015 2Health News:Dr. Robert G. Schwartz Achieves Certification in Russian Martial Art “Systema” and Focuses on Integrating Techniques & Principles into Health Care Delivery 2Health News:Dr. Robert G. Schwartz Achieves Certification in Russian Martial Art “Systema” and Focuses on Integrating Techniques & Principles into Health Care Delivery 3Health News:Dr. Michael Rothman, NJ’s Leading Holistic Doctor, Presents a Video Blog that Discusses the Most Confusing and Interesting Current Medical Topics 2Health News:Article on CAD/CAM Dental Technology Highlights the Advantages of 21st Century Dentistry, Notes Ora Dentistry Spa 2
... and data connectivity for ... Cardiac Rehabilitation, ... CSCX ), a global leader in advanced cardiac monitoring,and defibrillation ... RMS(R) 3.0, now has seamless connectivity with LUMEDX,CardioWellness(TM) data management ...
... Evelyn Bickley wins CBay,s ,Keys to Medical ... Records Success, ... provider,of transcription and healthcare BPO services, today announced the winner ... AHIMA,Convention and Exhibit in Philadelphia. (Photo: http://www.newscom.com/cgi-bin/prnh/20071017/NEW009 ...
... 16 AtriCure, Inc.,(Nasdaq: ATRC ), a ... products, today announced that results reporting on the ... to,treat atrial fibrillation (AF), were published in the ... an,electrophysiologist, and colleagues from the Oregon Heart and ...
... Pelosi,Senate Majority Leader Harry Reid and Senator Orrin Hatch ... and other advocates at a,news conference this morning to ... the Children,s Health Insurance Program. Below are,Pelosi,s opening remarks:, ... Easter Seals, and to the,representatives of the many organizations ...
... Symbol: CYT, MONTREAL, Oct. 16 /PRNewswire-FirstCall/ ... cardiac arrhythmia products to treat cardiovascular,disease, today ... patent,infringement lawsuit in the United States District ... makes and sells cryosurgical consoles, catheters and ...
... of G&D, Dr. Michael Cleary (Stanford University School of ... critical player in the establishment of leukemia stem cells, ... leukemia (MLL) is a distinctive type of leukemia ... by the presence of a break and rearrangement of ...
Cached Medicine News:Health News:Cardiac Science Announces Data Connectivity with LUMEDX 2Health News:Cardiac Science Announces Data Connectivity with LUMEDX 3Health News:Cardiac Science Announces Data Connectivity with LUMEDX 4Health News:CBaySystems Gives Away 2008 Honda Civic at AHIMA 2007 2Health News:Published Results Using AtriCure Minimally Invasive Products 2Health News:Published Results Using AtriCure Minimally Invasive Products 3Health News:Pelosi: In 48 Hours, Congress Must Choose Between Meeting the Needs of America's Children or Not 2
(Date:9/2/2015)... Sept. 2, 2015   Americord Registry , a private ... placenta tissue banking company, announced today that is has ... Logo - http://photos.prnewswire.com/prnh/20150902/263095LOGO ... have grown at least tenfold over the past three years. ... continued this trend with 50% quarterly growth during the first ...
(Date:9/1/2015)... On August 31, 2015, United States District Judge ... in the first of the consolidated MDL cases alleging ... are defective.[1]  The Court denied the ... claims for defective design, fraudulent misrepresentation and concealment and ... that the Medical Device Amendment to the Food Drug ...
(Date:9/1/2015)... and OR YEHUDA, Israel , Sept. ... HTWR ), a leading innovator of less invasive, ... of advanced heart failure, announced today that it has ... Cardio, Ltd . ("Valtech").  Valtech is a privately held ... and transcatheter valve repair and replacement devices for the ...
Breaking Medicine Technology:Americord Registry Announces Ranking on 2015 Inc. 500 2Pope McGlamry: Omnibus order in Conserve Hips MDL-2329 sets stage for bellwether trial 2Pope McGlamry: Omnibus order in Conserve Hips MDL-2329 sets stage for bellwether trial 3HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 2HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 3HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 4HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 5HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 6HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 7HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 8HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 9HeartWare International Enters Into Definitive Agreement To Acquire Valtech Cardio, Ltd. 10
... IP & Science business of Thomson Reuters announced ... Research (IPEA). This partnership provides IPEA,s Direction of ... Infrastructure (DISET) branch with access to the ... intelligence and tools for sourcing global pharmaceutical ingredients. ...
... Association (NBA), the Women,s National Basketball Association (WNBA) and ... the American Diabetes Association and Sanofi US, today tipped ... Stop Diabetes campaign, a national multimedia campaign designed ... and raise awareness about diabetes prevention, management and the ...
Cached Medicine Technology:Thomson Reuters Helps Brazil's Institute for Applied Economic Research Identify New Generic Drug Opportunities 2NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 2NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 3NBA, American Diabetes Association and Sanofi US Tip Off 2012 Dribble to Stop Diabetes Campaign 4
... The VersaPulse PowerSuite holmium laser ... properties for precise, virtually bloodless procedures. ... fragmenting urinary and gall bladder stones ... ideal multipurpose surgical tool. Because its ...
... Nd:YAG technology has allowed for perfecting mini-invasive ... of various pathologies with a considerable social ... for reducing the post-operatory times and represents ... costs in all hospital structures.,DEKAs family of ...
... have to choose. The Apogee Elite ... 755nm Alexandrite laser and a high ... in one convenient unit. The ... for hair removal, pigmented lesions, facial ...
Single use trocar with non-conductive sleeves for gaining and maintaining thoracic access., ,THORACOPORT™ devices are trocars used to gain access to the thoracic cavity for use in video assis...
Medicine Products: