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Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Date:12/11/2009

The study concludes that there is a novel association between low response to ovarian stimulation with fertility drugs and BRCA1 mutations, which suggests a possible link between infertility, and breast/ovarian cancer risks. The analysis of the BRCA gene in women with infertility and low response to ovarian stimulation may be worthwhile, especially when there is family history of breast and/or ovarian cancer. Larger studies are warranted to investigate the impact of BRCA mutations on fertility in general population.

Researchers have identified hundreds of mutations in the BRCA1 gene, many of which are associated with an increased risk of cancer. Women, particularly those in their mid 30's or older, who have an abnormal BRCA1 or BRCA2 gene, have an increased risk of developing breast/ovarian cancer and produce a significantly less number of eggs than normal. This is noteworthy factor as women put off pregnancy.

Kutluk Oktay, MD, FACOG is Director, Division of Reproductive Medicine & Infertility Director, Laboratory of Molecular Reproduction and Fertility Preservation Department of Obstetrics & Gynecology at Westchester Medical Center and Professor of Obstetrics & Gynecology, Medicine and Cell Biology & Anatomy at New York Medical College, Valhalla, NY.

Dr. Oktay is the author and lead on this manuscript providing conception, design, financial and administrative support as well as data collection, assembly, analysis and interpretation. You can access a PDF of the manuscript at http://www.worldclassmedicine.com/workfiles/materials/Oktay%20study.pdf.

Dr. Oktay is available to speak with members of the press or other interested parties.

SOURCE Westchester Medical Center


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SOURCE Westchester Medical Center
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