Navigation Links
Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Date:12/11/2009

Westchester Medical Center Physician and Fertility Preservation Expert leads study examining the association of breast cancer genes, breast cancer and infertility

VALHALLA, N.Y., Dec. 11 /PRNewswire-USNewswire/ -- In a study published online this week in the leading cancer journal, Journal of Clinical Oncology, Westchester Medical Center Physician Dr. Kutluk Oktay, MD, Director, Division of Reproductive Medicine & Infertility concluded that mutations in the BRCA1 gene (gene associated with early onset breast cancer) are associated with early diminishment of egg reserve. This finding may, at least in part, explain the link between infertility and breast/ovarian cancer risks.

During the study, Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation.

The results found that of the 82 women who met the inclusion criteria, 47 women (57%) had undergone BRCA testing, and 14 had a mutation in BRCA genes. In BRCA mutation-positive patients, low ovarian response rate was significantly higher compared with BRCA mutation-negative patients and with BRCA-untested women. All BRCA mutation-positive low responders had BRCA1 mutations, but low response was not encountered in women who were only BRCA2 mutation positive. Compared with controls, BRCA1 mutation -- but not BRCA2 mutation-positive women produced lower numbers of eggs.

It is estimated that, in the general population, one in every 1,000 women is BRCA mutation positive, and this incidence is as high as 2.5% in certain ethnic groups. Regardless of underlying mechanisms of early diminishment of egg reserve in BRCA1 mutation-positive women, the findings may have profound implications for the future fertility of a large number of women in the general population.

The study concludes that there is a novel association between low response to ovarian stimulation with fertility drugs and BRCA1 mutations, which suggests a possible link between infertility, and breast/ovarian cancer risks. The analysis of the BRCA gene in women with infertility and low response to ovarian stimulation may be worthwhile, especially when there is family history of breast and/or ovarian cancer. Larger studies are warranted to investigate the impact of BRCA mutations on fertility in general population.

Researchers have identified hundreds of mutations in the BRCA1 gene, many of which are associated with an increased risk of cancer. Women, particularly those in their mid 30's or older, who have an abnormal BRCA1 or BRCA2 gene, have an increased risk of developing breast/ovarian cancer and produce a significantly less number of eggs than normal. This is noteworthy factor as women put off pregnancy.

Kutluk Oktay, MD, FACOG is Director, Division of Reproductive Medicine & Infertility Director, Laboratory of Molecular Reproduction and Fertility Preservation Department of Obstetrics & Gynecology at Westchester Medical Center and Professor of Obstetrics & Gynecology, Medicine and Cell Biology & Anatomy at New York Medical College, Valhalla, NY.

Dr. Oktay is the author and lead on this manuscript providing conception, design, financial and administrative support as well as data collection, assembly, analysis and interpretation. You can access a PDF of the manuscript at http://www.worldclassmedicine.com/workfiles/materials/Oktay%20study.pdf.

Dr. Oktay is available to speak with members of the press or other interested parties.

SOURCE Westchester Medical Center


'/>"/>
SOURCE Westchester Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America ... lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start ... ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, saving labor ...
(Date:4/28/2017)... Manhattan New york (PRWEB) , ... April 28, ... ... is pleased to announce that Aditya Patel M.D. has joined the revolutionary endoscopic ... fellowship training and board certification in Interventional Pain Medicine. The patented, revolutionary eDiscSculpt ...
(Date:4/28/2017)... Edinburg, Texas (PRWEB) , ... April 28, 2017 , ... ... a plaque in recently to the labor and delivery team at Women’s Hospital at ... generous mothers who give birth at the hospital and decide to donate. , ...
(Date:4/28/2017)... ... April 28, 2017 , ... Early detection and elimination ... safety and minimize the cost of development. In this webinar, sponsored by Molecular ... lines and for cardiac toxicity using induced pluripotent stem cells (iPSCs). , In ...
(Date:4/28/2017)... ... 28, 2017 , ... Bill Howe started his sewer and drain company in ... Howe joined the team, the Bill Howe brand was born and they began cultivating ... giving back to the San Diego community in which they worked, lived and were ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Texas , April 20, 2017  Vivify Health, ... mobile devices, has been awarded a very significant patent ... via EMRs to continual care via digital health.  This ... key intellectual property and further secures Vivify,s position as ... launched in 2009, was the first company to apply ...
(Date:4/20/2017)... WOONSOCKET, R.I. , April 20, 2017 /PRNewswire/ ... (NYSE: CVS), today unveiled a new store design ... new assortment of healthier food, health-focused products and ... the store to help customers discover new offerings. ... represent the next evolution of the customer experience ...
(Date:4/20/2017)... LUND, Sweden , April 20, 2017 /PRNewswire/ ... OTCQX: NEVPF) ("NeuroVive") today announced positive preclinical ... company,s preclinical compound for non-alcoholic steatohepatitis (NASH), ... NV556 has previously ... STAM™ NASH model. Today, NeuroVive,s scientists present ...
Breaking Medicine Technology: