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Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Date:12/11/2009

Westchester Medical Center Physician and Fertility Preservation Expert leads study examining the association of breast cancer genes, breast cancer and infertility

VALHALLA, N.Y., Dec. 11 /PRNewswire-USNewswire/ -- In a study published online this week in the leading cancer journal, Journal of Clinical Oncology, Westchester Medical Center Physician Dr. Kutluk Oktay, MD, Director, Division of Reproductive Medicine & Infertility concluded that mutations in the BRCA1 gene (gene associated with early onset breast cancer) are associated with early diminishment of egg reserve. This finding may, at least in part, explain the link between infertility and breast/ovarian cancer risks.

During the study, Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation.

The results found that of the 82 women who met the inclusion criteria, 47 women (57%) had undergone BRCA testing, and 14 had a mutation in BRCA genes. In BRCA mutation-positive patients, low ovarian response rate was significantly higher compared with BRCA mutation-negative patients and with BRCA-untested women. All BRCA mutation-positive low responders had BRCA1 mutations, but low response was not encountered in women who were only BRCA2 mutation positive. Compared with controls, BRCA1 mutation -- but not BRCA2 mutation-positive women produced lower numbers of eggs.

It is estimated that, in the general population, one in every 1,000 women is BRCA mutation positive, and this incidence is as high as 2.5% in certain ethnic groups. Regardless of underlying mechanisms of early diminishment of egg reserve in BRCA1 mutation-positive women, the findings may have profound implications for the future fertility of a large number of women in the general population.


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SOURCE Westchester Medical Center
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