Navigation Links
Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Date:12/11/2009

Westchester Medical Center Physician and Fertility Preservation Expert leads study examining the association of breast cancer genes, breast cancer and infertility

VALHALLA, N.Y., Dec. 11 /PRNewswire-USNewswire/ -- In a study published online this week in the leading cancer journal, Journal of Clinical Oncology, Westchester Medical Center Physician Dr. Kutluk Oktay, MD, Director, Division of Reproductive Medicine & Infertility concluded that mutations in the BRCA1 gene (gene associated with early onset breast cancer) are associated with early diminishment of egg reserve. This finding may, at least in part, explain the link between infertility and breast/ovarian cancer risks.

During the study, Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation.

The results found that of the 82 women who met the inclusion criteria, 47 women (57%) had undergone BRCA testing, and 14 had a mutation in BRCA genes. In BRCA mutation-positive patients, low ovarian response rate was significantly higher compared with BRCA mutation-negative patients and with BRCA-untested women. All BRCA mutation-positive low responders had BRCA1 mutations, but low response was not encountered in women who were only BRCA2 mutation positive. Compared with controls, BRCA1 mutation -- but not BRCA2 mutation-positive women produced lower numbers of eggs.

It is estimated that, in the general population, one in every 1,000 women is BRCA mutation positive, and this incidence is as high as 2.5% in certain ethnic groups. Regardless of underlying mechanisms of early diminishment of egg reserve in BRCA1 mutation-positive women, the findings may have profound implications for the future fertility of a large number of women in the general population.

The study concludes that there is a novel association between low response to ovarian stimulation with fertility drugs and BRCA1 mutations, which suggests a possible link between infertility, and breast/ovarian cancer risks. The analysis of the BRCA gene in women with infertility and low response to ovarian stimulation may be worthwhile, especially when there is family history of breast and/or ovarian cancer. Larger studies are warranted to investigate the impact of BRCA mutations on fertility in general population.

Researchers have identified hundreds of mutations in the BRCA1 gene, many of which are associated with an increased risk of cancer. Women, particularly those in their mid 30's or older, who have an abnormal BRCA1 or BRCA2 gene, have an increased risk of developing breast/ovarian cancer and produce a significantly less number of eggs than normal. This is noteworthy factor as women put off pregnancy.

Kutluk Oktay, MD, FACOG is Director, Division of Reproductive Medicine & Infertility Director, Laboratory of Molecular Reproduction and Fertility Preservation Department of Obstetrics & Gynecology at Westchester Medical Center and Professor of Obstetrics & Gynecology, Medicine and Cell Biology & Anatomy at New York Medical College, Valhalla, NY.

Dr. Oktay is the author and lead on this manuscript providing conception, design, financial and administrative support as well as data collection, assembly, analysis and interpretation. You can access a PDF of the manuscript at http://www.worldclassmedicine.com/workfiles/materials/Oktay%20study.pdf.

Dr. Oktay is available to speak with members of the press or other interested parties.

SOURCE Westchester Medical Center


'/>"/>
SOURCE Westchester Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... April 29, 2017 , ... TransDark is a set ... one video to the next without having to set a single keyframe in ... to enhance your video production. , TransDark features dynamic transitions that momentarily splits the ...
(Date:4/29/2017)... MD (PRWEB) , ... April 29, 2017 , ... More ... jobs, so what are Americans doing in their leisure time that causes hearing loss? ... lifestyle habits that may be contributing to hearing loss, as well as schedule a ...
(Date:4/28/2017)... Washington, DC (PRWEB) , ... April 28, 2017 ... ... Unplanned Pregnancy (The National Campaign) announces its support for the Access to ... by Sen. Jeanne Shaheen (D-NH) and Rep. Jackie Speier (D-CA), will help to ...
(Date:4/28/2017)... Clara, CA (PRWEB) , ... April 28, 2017 ... ... is pleased to announce the integration of Microsoft(R) Word(TM) Online(TM), which enables sleep ... user experience, since it streamlines the reporting process and provides a familiar interface ...
(Date:4/28/2017)... ... 2017 , ... Getting enough sleep affects much more than energy – it also has mental ... sleep can compromise motor reaction time, which can increase the risk of having a car ... following tips from the NSF to help you sleep better and feel better:, ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 NeuroVive Pharmaceutical ... today announced positive preclinical results demonstrating anti-fibrotic ... for non-alcoholic steatohepatitis (NASH), in an additional ... NV556 has previously shown similar anti-fibrotic ... Today, NeuroVive,s scientists present novel data demonstrating ...
(Date:4/19/2017)... 19, 2017  IRIDEX Corporation (Nasdaq: IRIX ... for the first quarter 2017 after the close of ... team will host a corresponding conference call beginning at ... Investors interested in listening to the conference call may ... or (703) 326-3030 for international callers, using conference ID: ...
(Date:4/19/2017)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... new treatments for cancer and other unmet medical ... announced underwritten public offering of 23,625,084 shares of ... of $2.00 per share, before deducting underwriting discounts ... Sorrento.  The net proceeds to Sorrento from this ...
Breaking Medicine Technology: