Navigation Links
Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
Date:12/11/2009

Westchester Medical Center Physician and Fertility Preservation Expert leads study examining the association of breast cancer genes, breast cancer and infertility

VALHALLA, N.Y., Dec. 11 /PRNewswire-USNewswire/ -- In a study published online this week in the leading cancer journal, Journal of Clinical Oncology, Westchester Medical Center Physician Dr. Kutluk Oktay, MD, Director, Division of Reproductive Medicine & Infertility concluded that mutations in the BRCA1 gene (gene associated with early onset breast cancer) are associated with early diminishment of egg reserve. This finding may, at least in part, explain the link between infertility and breast/ovarian cancer risks.

During the study, Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation.

The results found that of the 82 women who met the inclusion criteria, 47 women (57%) had undergone BRCA testing, and 14 had a mutation in BRCA genes. In BRCA mutation-positive patients, low ovarian response rate was significantly higher compared with BRCA mutation-negative patients and with BRCA-untested women. All BRCA mutation-positive low responders had BRCA1 mutations, but low response was not encountered in women who were only BRCA2 mutation positive. Compared with controls, BRCA1 mutation -- but not BRCA2 mutation-positive women produced lower numbers of eggs.

It is estimated that, in the general population, one in every 1,000 women is BRCA mutation positive, and this incidence is as high as 2.5% in certain ethnic groups. Regardless of underlying mechanisms of early diminishment of egg reserve in BRCA1 mutation-positive women, the findings may have profound implications for the future fertility of a large number of women in the general population.

The study concludes that there is a novel association between low response to ovarian stimulation with fertility drugs and BRCA1 mutations, which suggests a possible link between infertility, and breast/ovarian cancer risks. The analysis of the BRCA gene in women with infertility and low response to ovarian stimulation may be worthwhile, especially when there is family history of breast and/or ovarian cancer. Larger studies are warranted to investigate the impact of BRCA mutations on fertility in general population.

Researchers have identified hundreds of mutations in the BRCA1 gene, many of which are associated with an increased risk of cancer. Women, particularly those in their mid 30's or older, who have an abnormal BRCA1 or BRCA2 gene, have an increased risk of developing breast/ovarian cancer and produce a significantly less number of eggs than normal. This is noteworthy factor as women put off pregnancy.

Kutluk Oktay, MD, FACOG is Director, Division of Reproductive Medicine & Infertility Director, Laboratory of Molecular Reproduction and Fertility Preservation Department of Obstetrics & Gynecology at Westchester Medical Center and Professor of Obstetrics & Gynecology, Medicine and Cell Biology & Anatomy at New York Medical College, Valhalla, NY.

Dr. Oktay is the author and lead on this manuscript providing conception, design, financial and administrative support as well as data collection, assembly, analysis and interpretation. You can access a PDF of the manuscript at http://www.worldclassmedicine.com/workfiles/materials/Oktay%20study.pdf.

Dr. Oktay is available to speak with members of the press or other interested parties.

SOURCE Westchester Medical Center


'/>"/>
SOURCE Westchester Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy at the ... Endoscopy Centers in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, ...
(Date:3/24/2017)... Frederick, Maryland (PRWEB) , ... March 24, 2017 ... ... LLC, is the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, ... and their caregivers during what is often a very difficult and challenging time.” ...
(Date:3/24/2017)... ... March 24, 2017 , ... “End Time GPS”: a dauntless and ... “End Time GPS” is the creation of published author, Wesley Gerboth, a World ... military munitions and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God ...
(Date:3/24/2017)... ... , ... “The Communion of Saints: A Pastor’s Potpourri of ... across the United States. “The Communion of Saints” is the creation of ... congregations in seven states throughout his long career of devotion to the church. ...
(Date:3/23/2017)... Greensboro, NC & Seattle, WA (PRWEB) , ... March 23, 2017 ... ... international public health emergency and now estimates that there could be four million Zika-related ... fastest growing epidemics to date with numbers of US cases reported per year skyrocketing ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... - Industry Forecast to 2025" report to their offering. ... The Global Cryostat ... over the next decade to reach approximately $3.5 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/23/2017)... LONDON , March 23, 2017 ... comprehensive research report created through extensive primary research ... research, the report aims to present the analysis ... basis of Procedure (Replacement and Repair); Replacement Procedure ... (TAVR)), Repair By Technique (Surgical Devices, Balloon Valvuloplasty, ...
(Date:3/23/2017)... , March 23, 2017   BioSpace , the ... has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s life ... BioIndiana Hotbed map, an artistic representation of the region,s ... presented to Vice President Mike Pence , a ...
Breaking Medicine Technology: