Navigation Links
Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis

WEDNESDAY, Feb. 20 (HealthDay News) -- A new study counters the notion that the prescription acne drug Accutane raises the risk of Crohn's disease or colitis in women.

The study of more than 45,000 women found no such link between Accutane (isotretinoin) use and these illnesses, which are collectively known as inflammatory bowel disease (IBD).

One expert not connected to the study called it a "welcome review."

"There has been a lot of speculation and even litigation that Accutane causes inflammatory bowel disease," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City.

"Dermatologists have been discouraged from using Accutane and the makers of Accutane have discontinued their production due to countless lawsuits," she noted, but "this study once again highlights the safety of Accutane."

Ulcerative colitis and Crohn's disease are the most common forms of IBD, a group of disorders in which the intestines become inflamed. Symptoms include abdominal pain, diarrhea, loss of appetite, unexplained weight loss, bleeding from the rectum, fever, joint pain and skin problems.

In this study, published in the February issue of JAMA Dermatology, researchers compared almost 2,200 women of reproductive age who had IBD against another group of more than 43,000 women without IBD.

Only 10 (0.46 percent) of the IBD patients and 191 (0.44 percent) of those in the control group had used Accutane -- so there was essentially no difference.

The findings "do not suggest an increase in risk" for IBD among those who use Accutane, concluded Mahyar Etminan, of the University of British Columbia in Canada, and colleagues.

Severe acne can cause serious emotional distress for children and teens. The study results show that concerns about IBD should not prevent doctors should not prevent from prescribing Accutane to these patients, the researchers concluded in a journal news release.

Green agreed. "Unfortunately, Accutane has already been demonized and patients are less likely to receive this drug because of the undeserved negative reputation," she said.

Another dermatology expert said there's just no firm evidence to link Accutane and bowel disorders.

"This is the third study published evaluating the association between isotretinoin and inflammatory disease. The two previous studies showed conflicting results," said Dr. Joshua Zeichner, an assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai, in New York City.

According to Zeichner, "One [prior study] showed no association and the other showed a small association between isotretinoin [Accutane] and ulcerative colitis only. This study looks specifically at adult women and does not show an association between the drug and inflammatory bowel disease."

Overall, he said, "the data from these three studies are not sufficient to prove a causal relationship between isotretinoin use and inflammatory bowel disease." He said the existence of any link between acne and IBD is also far from proven.

However, Accutane is not suitable for use by certain patients, especially among women of childbearing age, since its use has been linked to a higher incidence of birth defects, Zeichner noted.

"A woman who is pregnant, breast-feeding or not compliant with using two forms of birth control are not candidates," for using the acne drug, said Zeichner, who is also director of Cosmetic & Clinical Research at the Mount Sinai Medical Center.

He added that people with a history of severe depression are also advised to stay away from Accutane, as are people with liver disease or high cholesterol.

More information

The U.S. Office on Women's Health has more about inflammatory bowel disease.

-- Robert Preidt

SOURCES: Michele Green, M.D., dermatologist, Lenox Hill Hospital, New York City; Joshua Zeichner, M.D., director, Cosmetic & Clinical Research at the Mount Sinai Medical Center, and assistant professor, dermatology, Icahn School of Medicine at Mount Sinai, New York City; JAMA Dermatology, news release, Feb. 20, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Weight-Loss Surgery Wont Cut Obesity-Related Medical Costs: Study
2. High-Antioxidant Diet May Not Prevent Stroke, Dementia, Study Finds
3. Regenstrief study: Informatics tools underutilized in prevention of hospital-acquired infection
4. Study shows long-term efficacy of minimally invasive therapy for patients with Barretts esophagus
5. Setting the record straight on Medicares overhead costs: New study
6. Pitt study examines cost-effectiveness of medicare drug plans in schizophrenia and bipolar disorder
7. Gene Mutations Benefit for Ovarian Cancer Patients May Not Last: Study
8. Human Teeth Healthier in the Stone Age Than Today: Study
9. NYUs Shedlin publishes study on the health of Colombian refugees in Ecuador
10. UCLA study suggests link between untreated depression, response to shingles vaccine
11. Study shows reduced risk of preterm birth for pregnant women vaccinated during pandemic flu
Post Your Comments:
Related Image:
Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a ... second affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: