Navigation Links
Study Explains How Shock Therapy Might Ease Severe Depression

By Carina Storrs
HealthDay Reporter

MONDAY, March 19 (HealthDay News) -- A small new study gives insight into how electroshock therapy, an effective yet poorly understood treatment for severe depression, affects the brains of depressed people.

Researchers used functional MRI scans to look at brain activity in nine adults with severe depression before and after electroshock therapy. The investigators found that electroshock, or electroconvulsive therapy (ECT), dampens the connections between different areas of the brain in depressed people.

"With our study we were able to confirm that there is hyperconnectivity [in depression], and in addition we could show that treatment removes it," said study co-author Christian Schwarzbauer, a professor of neuroimaging at the University of Aberdeen in Scotland.

Although it may seem counterintuitive that people with severe depression, who are often also lethargic, would have brains on overdrive, one explanation could be that they have too much internal brain activity and cannot deal as well with external stimulation, Schwarzbauer said.

This study could point to ways to improve electroshock therapy's effectiveness and safety, he added. In its 76-year history, the treatment has met with opposition from doctors because of concerns of its side effects, such as memory loss.

Electroshock therapy is typically only used for patients who have not responded to antidepressants or other types of treatment and are at risk of hurting themselves or others.

"I think the fact that now there's more of an explanation, I think that's reassuring to the clinician as well as the patient," said Jennifer Perrin, who is a research fellow at the University of Aberdeen and lead author of the study published online March 19 in the Proceedings of the National Academy of Sciences.

For the study, nine severely depressed participants underwent functional MRI scans of their whole brain before and after a series of electroshock therapy. They received the treatment twice a week until their symptoms, including sadness and fatigue, subsided.

The participants had not responded to antidepressant drugs before the study or received electroshock therapy in the past six months, although four of the patients were taking antipsychotic medications.

The researchers zeroed in on an area in the front of the brain called the dorsolateral prefrontal cortex. It had fewer and less intense connections with a number of other areas of the brain following electroshock therapy, the scans showed.

This particular part of the brain is involved in cognition [thought processes] and social behavior and has been implicated in depression, so this finding is not surprising, said Tony Tang, an adjunct professor of psychology at Northwestern University. What is surprising, he said, is that none of the many other brain areas that have been associated with depression were found to have cut-off lines of communication following electroshock therapy.

"ECT is a rather invasive, drastic procedure and you see a lot of changes in patients, so we would probably speculate that there would be some sort of widespread brain connectivity changes," Tang said. This study "found it to be localized, and I found that to be rather amazing."

During electroshock treatment, clinicians place electrodes on the scalp and, while the patient is under anesthesia, deliver enough electric current to induce a seizure. The therapy is more effective when electrodes are on both sides of the head, as opposed to just one, but unfortunately this also carries greater risk of side effects.

Having electrodes on both sides of the head may be more effective because it triggers a more widespread seizure, but the current findings suggest another possibility, Tang said: When clinicians put electrodes just on one side of the scalp, they usually put them over the right half of the brain because it is less dominant (for right-handed people). However, according to this study, the dorsolateral prefrontal cortex, in the left side of the brain, could be the crucial area to target.

"Most localized forms of stimulation we've tried so far don't work as well [as having electrodes on both sides], but this type of study could potentially point to the right direction," Tang said.

Looking at brain connections in people with severe depression could help clinicians predict who will benefit from electroshock therapy as well as who will relapse after treatment, Schwarzbauer suggested. Between about 60 percent and 80 percent of people become depressed again, usually within six months of the treatment.

Beyond depression, functional MRI of the entire brain could offer insights into other conditions that could be related to changes in brain networks, including autism, schizophrenia and dementia, Schwarzbauer said.

More information

The U.S. National Institute of Mental Health has more on electroshock therapy.

SOURCES: Christian Schwarzbauer, Ph.D., chair, neuroimaging, University of Aberdeen, Aberdeen, Scotland; Jennifer Perrin, Ph.D., research fellow, University of Aberdeen, Scotland; Tony Tang, Ph.D., adjunct professor, psychology, Weinberg College of Arts & Sciences, Northwestern University, Chicago; March 19, 2012, Proceedings of the National Academy of Sciences, online

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Less Heart Disease Among Women in Wealthier States: Study
2. Study to test new tinnitus treatment
3. Scientists study link between amyloid beta peptide levels and Alzheimers disease
4. Less Invasive Hernia Procedure Easier on Patients: Study
5. New Type 2 Diabetes Drug Helps Lower Blood Sugar: Study
6. Medicaid Patients Go to ERs More Often: Study
7. Mothers of Kids With Autism Earn Less, Study Shows
8. Pediatricians pain-medication judgments affected by unconscious racial bias, says UW study
9. Study shows air emissions near fracking sites may impact health
10. With Spanking, Nature and Nurture Create More Aggression, Study Suggests
11. Study determines critical skills for PCPs to safely manage opioid risk in chronic pain patients
Post Your Comments:
Related Image:
Study Explains How Shock Therapy Might Ease Severe Depression
(Date:11/26/2015)... ... November 26, 2015 , ... Somu Sivaramakrishnan announced today ... owner, Somu now offers travelers, value and care based Travel Services, including exclusive ... as well as, cabin upgrades and special amenities such as, shore excursions, discounted ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer ... classically-influenced trailer titles work with any font, giving users limitless opportunities to stylize ...
(Date:11/25/2015)... ... 2015 , ... The holiday season is jam-packed with family ... of attendees is of the utmost importance. Whether you are cooking at home ... recipes a try this holiday season. , Turkey Croquettes ,     Ingredients: ...
(Date:11/25/2015)... ... November 26, 2015 , ... Ministers, senior ... (EU), ANDI Pan African Centres of Excellence, and public R&D institutions, civil societies ... the opening of the 5th African Network for Drugs and Diagnostics Innovation, ANDI, ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like ... , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. ... OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... WILMINGTON, N.C. , Nov. 25, 2015 /PRNewswire/ ... announces the planned investment of at least $15.8 ... in Wilmington, NC . The ... services capacity to meet the growing demands of ... Wilmington site expansion will provide up ...
(Date:11/25/2015)... , Nov. 25, 2015 Allergan plc (NYSE: ... agreement with the New York State ... of the Sherman Act, and other statutes with the Attorney ... February 2014, to cease marketing and selling the now generic ... settlement, Allergan admits no liability, has released its counterclaims against ...
(Date:11/25/2015)... USP 800 applies to all healthcare ... pharmacy technicians, nurses, physicians, physician assistants, home healthcare ... covers all entities which store, prepare, transport, or ... institutions, patient treatment clinics, physicians, practice facilities, and ... --> What is the purpose of USP ...
Breaking Medicine Technology: