Navigation Links
Study Evaluating Efficacy and Safety of Two Low-dose Regimens of PREMARIN Vaginal Cream for the Treatment of Moderate to Severe Vaginal Atrophy Now Published
Date:7/13/2009

formation should aid postmenopausal women and their health care professionals in discussing whether and how they may treat vaginal atrophy."

Study Design and Results:

In this multicenter clinical study, 423 postmenopausal women (ages 45-80 years) with moderate-to-severe vaginal atrophy were randomized to receive PREMARIN Vaginal Cream 0.5 g (equivalent to a low-dose of CE cream 0.3 mg) or placebo once daily (21 days on/7 days off) or twice weekly for 12 weeks. Treatment regimens were consistent within the 12-week and 40-week periods. The primary endpoints of the study were changes in vaginal maturation index (VMI; percentage of superficial cells), vaginal pH and severity of participant-reported most bothersome symptom (vaginal dryness, itching, burning or dyspareunia) at week 12.()The study also evaluated safety related to systemic effects of CE cream on endometrial tissue during one year of therapy.

At week 12, improvements in VMI and vaginal pH with daily and twice-weekly use of PREMARIN Vaginal Cream 0.5 g were significantly greater relative to placebo (P<0.001). Results from the 12-week phase also showed that both low-dose regimens of PREMARIN Vaginal Cream (0.5 g daily and twice weekly) significantly improved the most bothersome symptoms score versus placebo at 12 weeks (P less than or equal to 0.001), including those for dyspareunia (P less than or equal to 0.01).

After 52 weeks of therapy, with the same respective dosing regimens as in the double-blind phase, results were similar to those observed at week 12 and demonstrated the efficacy of PREMARIN Vaginal Cream versus placebo. Endometrial safety was assessed in women who completed the 52-week study period and had evaluable endometrial biopsies. There were no reports of endometrial hyperplasia or endometrial carcinoma in these women in either regimen. In this study, the most common tre
'/>"/>

SOURCE Wyeth Pharmaceuticals
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... (PRWEB) September 21, 2014 According to latest ... the highest birth rate since 1966 (10.5 births per 1,000 ... their early 40s has risen steadily by 2 percent per ... births to women aged 50 and over) also rose, the ... there were more than nine times as many first births ...
(Date:9/20/2014)... 2014 Recently, iFitDress.com, a well-known wedding dress ... beautiful party dresses . In addition, the company has launched ... of the promotion is to benefit all of its big ... online store now. , Along with beautiful party dresses, ... It has recently released its new sexy short prom outfits ...
(Date:9/20/2014)... NV (PRWEB) September 21, 2014 ... Dr. Kenneth Pullman that is helping thousands of people ... diabetes symptoms without shots, pills, or prescriptions has caught ... , “There are currently tens of millions of ... Type 1 and Type 2 diabetes, and unfortunately, big ...
(Date:9/20/2014)... Vegas, NV (PRWEB) September 21, 2014 ... method created by fitness expert Craig Ballantyne that is showing ... their metabolism and blast away stubborn body fat using simple ... attention of Shane Michaels, prompting an investigative review. , ... isn’t always calories in vs. calories out for all people,” ...
(Date:9/20/2014)... Los Cabos, Baja, Mexico (PRWEB) September 20, 2014 ... Los Cabos properties, including Villa del Palmar Cabo San ... minimal damages in relation to Hurricane Odile, with plans ... beginning of October. , As of Sept. 19, all ... properties have returned home, thanks to a coordinated effort ...
Breaking Medicine News(10 mins):Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2
... 12 Having funded $2 million,total to support 27 ... year of its Rapid Response Innovation Awards,(RRIA) initiative, The ... $2 million to a second round of funding in ... good ideas without delay.,Under this program the Foundation accepts ...
... 12, 2007) A new study confirms that chronic ... cardiovascular events in diabetic patients with damage to the ... anti-diabetic drug pioglitazone may help to lower this risk, ... Nephrology. , "The data confirm that chronic kidney disease ...
... Government Officials Will Explain Regulatory Plans for Cutting-Edge,Technology at ... Dec. 12 Nanotechnology was,incorporated into more than $50 ... By 2014, the market will grow to $2.6 trillion.,By ... will be,sold -- up from more than $3 billion ...
... Dermatologist Doing His Part to Warn Consumers, OMAHA, ... has been in the news for the past several ... Fig, the,parent company for up to 18 facilities around ... procedure, has closed its stores and is,considering declaring bankruptcy. ...
... Mattel Children,s Hospital UCLA,interacting with more than 100 Children ... ... NEW YORK, Dec. 12 Vapps, Inc., the ... today,will premiere their inaugural "Vapps, Holiday Storybook" event, featuring,multi-platinum ...
... depressive disorder (MDD) is the most common major mental ... 75% of people who recover from an episode of ... majority having multiple recurrences. MDD is the leading ... functional impairment, morbidity, and mortality. Few studies have assessed ...
Cached Medicine News:Health News:Michael J. Fox Foundation Launches Rapid Response Innovation Awards 2008 Following Strong Inaugural Year Response 2Health News:Pioglitazone lowers cardiovascular risk in diabetic patients with kidney disease 2Health News:Food and Drug Law Institute, Project on Emerging Nanotechnologies Co-Sponsor Major Conference on Nanotechnology Law, Regulation and Policy 2Health News:Food and Drug Law Institute, Project on Emerging Nanotechnologies Co-Sponsor Major Conference on Nanotechnology Law, Regulation and Policy 3Health News:Food and Drug Law Institute, Project on Emerging Nanotechnologies Co-Sponsor Major Conference on Nanotechnology Law, Regulation and Policy 4Health News:Will Lipodissolve Continue to Remain Popular? 2Health News:Ashlee Simpson to Read Holiday Stories to Children in Hospitals Throughout the Country Premiering 'Vapps' Holiday Storybook' Event 2Health News:Venlafaxine extended-release effective for patients with major depression 2
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
(Date:9/19/2014)... 19, 2014  Over 200 runners participated in the ... the Radiation Oncology Institute (ROI), hosted by Radiation Business ... Park in San Francisco.  "Donations are ... of Radiation Business Solutions, "but at this point, ... $70,000 for the ROI this year. This surpasses last ...
(Date:9/19/2014)... PHILADELPHIA , Sept. 19, 2014  PCI ... Services International (Biotec).  Biotec is a leading provider ... Services headquartered in Bridgend, Wales ... .  The addition significantly expands PCI,s presence in ... medicinal products by adding packaging, storage and distribution ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3PCI Announces Acquisition Of Biotec 2PCI Announces Acquisition Of Biotec 3PCI Announces Acquisition Of Biotec 4PCI Announces Acquisition Of Biotec 5PCI Announces Acquisition Of Biotec 6
... ,Forest Laboratories, Inc. (NYSE: FRX ) and ... a phase II clinical trial of,cariprazine (RGH-188), an ... bipolar I disorder. For the primary endpoint,the Young ... patients with,acute manic episodes treated with cariprazine experienced ...
... Phase II Data Continue to Highlight Potential of NeoVista,s ... Epiretinal ... 18-month data from the company,s Phase II feasibility study,examining its novel ... (AMD) at the 41st Scientific Meeting of,the Retina Society. The long-term ...
Cached Medicine Technology:Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder 2Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder 3Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder 4Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder 5NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting 2NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting 3NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting 4
Double-ended. Designated most popular model or size....
Double-ended. Sharp and blunt 6.5 mm tips. Designated most popular model or size....
2 mm tip....
Octagonal handle. 3 mm wide....
Medicine Products: