Navigation Links
Study Downgrades Gene as Heart Risk Factor
Date:9/18/2007

Screening for variations in APO gene not warranted, researchers say

TUESDAY, Sept. 18 (HealthDay News) -- Variations in the apolipoprotein (APO) gene are not as important an indicator of coronary risk as has been thought, according to a new British analysis of previously published studies.

The APO gene comes in three varieties -- E2, E3 and E4. All forms of the gene produce a protein that is an important component of the fat and protein complexes found in blood plasma, and that plays an important role in the metabolism of cholesterol and the fats called triglycerides.

Some previous studies have found an association between specific APOE versions -- generally E2 -- and lipid levels, according to the report, published in the Sept. 19 issue of the Journal of the American Medical Association by a group led by John Danesh of the University of Cambridge.

But many of those studies were too small to be reliable, said study co-author Dr. Emanuele Di Angelantonio. A meta-analysis that assessed 82 studies of blood fat levels and 121 studies of coronary outcome showed that the association with APO E variants showed that the links were not as strong as once suspected, he said.

"People with APO E2 have a 20 percent lower risk of coronary disease," Di Angelantonio said. That was about twice as weak as had been previously reported, the journal report said. Coronary risk was increased slightly for carriers of the APO E4 variant.

There has been talk about screening for APO E variants to help determine coronary risk, but "it is almost impossible to use APO E for screening," Di Angelantonio said. "APO E2 is a relatively rare mutation."

Which is just as well, said Dr. Daniel J. Rader, director of preventive cardiology at the University of Pennsylvania, since APO E variants can affect the risk of other conditions. Specifically, APO E4 has been linked to an increased risk of Alzheimer's disease, Rader noted.

"I actually did APO screening for a while," he said. "I found myself in the awkward position of having to explain what APO E4 means in terms of Alzheimer's disease."

The new meta-analysis does confirm "what we've known for some time, that APO E is one of the more important genes that determine the risk of heart disease," Rader said. "But it is a great example of why we need federal legislation in terms of protecting people in genetic screening programs."

Positive steps can be taken to reduce the risk of coronary disease for those carrying a gene that increases the risk, Rader said. "But for Alzheimer's, we can do nothing. If you carry E4, you might be subject to discrimination."

Such a screening program involving APO E is highly unlikely now, Di Angelantonio said. "It is too early to speak about assessing coronary risk with genotypes, and this study demonstrates that," he said.

More information

More on heredity as a risk factor for heart disease is provided by the American Heart Association.



SOURCES: Emanuele Di Angelantonio, M.D., research associate, University of Cambridge, England; Daniel J. Rader, director, preventive cardiology, University of Pittsburgh; Sept. 19, 2007, Journal of the American Medical Association


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... experts to create a PCSK9 inhibitor prior authorization (PA) form for prescribers to ... It is one of the helpful tools published as part of the article ...
(Date:3/22/2017)... ... 22, 2017 , ... Soriant recognizes that identifying savings opportunities ... Healthcare facilities across the country are always forced to focus on costs and ... the country, an efficient and quick way to estimate savings potential within specific ...
(Date:3/22/2017)... ... March 22, 2017 , ... In ... and print media enterprise focused on cancer patients, cancer centers and advocacy groups, ... special 12-part educational video series, “No Ifs, Ands, or Butts,” that focuses on ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... announced that its digital marketing solutions have enabled Children’s Hospital of The King’s ... months. , Recognizing the value of a digital marketing approach, the 206-bed ...
(Date:3/22/2017)... ... 2017 , ... An intensive search of the medical literature has revealed no ... PhD. He says investigating this possibility, is important because Miami-Dade in 2016 ... infections with HIV. , His findings appear on Analizir.com. . Dr. ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017 Global Colposcope Market by Manufacturers, ... Colposcope in Global market, especially in North America ... , South America , Middle East ... the market based on manufacturers, regions, type and application. ... Browse 190 Tables and Figures, ...
(Date:3/23/2017)... , March 23, 2017 ... presented in Brussels , My ... change bad sun habits into life-saving ones, was ... Association (AIM). Launched in 2016, the "Nudging for ... it easy and desirable for people to change ...
(Date:3/22/2017)... , 22 de marzo de 2017   ... líder de soluciones de productos y servicios para ... que ha adquirido EPL Archives, Inc., una organización ... clientes en todo el ciclo de vida de ... una muestra de archivo, almacenamiento de documentos y ...
Breaking Medicine Technology: