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Study Details Machinery of Immune Protection Against Inflammatory Diseases Like Colitis
Date:3/18/2010

Research led by St. Jude Children's Research Hospital investigators identifies potential new targets for treatment of colitis and other inflammatory bowel diseases

MEMPHIS, Tenn., March 18 /PRNewswire-USNewswire/ -- Scientists report a protein made by a gene already associated with a handful of human inflammatory immune diseases plays a pivotal role in protecting the intestinal tract from colitis.

St. Jude Children's Research Hospital investigators led the research, which points to possible new strategies for combating colitis. Colitis is a chronic inflammatory disease associated with colon damage, resulting in abdominal pain, bleeding and other symptoms.

The work also expands the link between the Nlrp3 protein and Crohn's disease, said Thirumala-Devi Kanneganti, Ph.D., assistant member of the St. Jude Department of Immunology and the paper's senior author. Md. Hasan Zaki, Ph.D., a St. Jude postdoctoral fellow, is first author of the study, which appears in the March 18 online edition of the journal Immunity.


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SOURCE St. Jude Children's Research Hospital
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