Navigation Links
Study Describes Molecules That Control Blood Pressure
Date:11/2/2007

The finding involving proteins could lead to new treatments, researchers say

FRIDAY, Nov. 2 (HealthDay News) -- Researchers are reporting a newly discovered molecular mechanism that makes blood pressure go up or down -- knowledge that could lead to new treatments for the hypertension that affects at least 50 million Americans.

A report published Nov. 1 in the Journal of Clinical Investigation is the latest in a series of studies on molecules called WNK kinases, which are proteins that help regulate blood pressure, said study co-author Dr. David H. Ellison, a professor of medicine at the Oregon Health & Science University.

"It has been known that these kinases are important for regulating blood pressure, because mutations of them cause hypertension," Ellison said. "This report adds two things that were not previously known."

One new finding was that one kinase, WNK3, plays a key role in regulating NCC, a protein that normally keeps salt in the body. Salt content helps govern blood pressure; more salt means higher pressure.

Another finding was that WNK3 does not act alone but in conjunction with two other kinases, WNK1 and WNK4. The interaction of WNK3 and WNK4 is important, Ellison said, because it helps explain why fruits and vegetables, which are rich in potassium, help keep blood pressure low.

Start with WNK4. If extra copies of a gene for the normal version of the kinase are put into a laboratory animal, its blood pressure goes down. If extra copies of a mutated version of WNK4, differing in only one of the amino acid units making up the protein, are added, its blood pressure goes up, Ellison said.

"It has been shown that the mutant of WNK4 causes disruption of the normal form of its metabolic pathway," he said. "There is continuing salt resorption caused by an interaction with the normal form, which turns off the normal form."

Potassium keeps blood pressure down by stimulating production of WNK4, Ellison said. The extra WNK4 reduces the activity of WNK3. The entire complex of three WNK kinases also acts as a unit, modifying the activity of the NCC protein.

"What happens is that WNK4 normally inhibits WNK3, reducing salt resorption," Ellison said. "Mutant WNK4 blocks this effect, thereby generating more active WNK3, increasing salt transport and causing hypertension."

The WNK kinases are members of one of the largest protein families in the human body. There are 518 of them, coordinating a wide variety of biological functions. The WNK kinases, which were discovered in 2000, have been objects of research since a group led by Dr. Richard P. Lifton, who heads his own laboratory at Yale University, found a link between them and a rare inherited form of high blood pressure, called familial hyperkalemic hypertension.

Lifton had no immediate comment on the new report.

The new research is still at a basic level, Ellison said. "If we develop a new pharmaceutical approach to hypertension, that could be helpful," he added.

More information

A guide to lowering high blood pressure is offered by the U.S. National Heart, Lung, and Blood Institute.



SOURCES: David H. Ellison, M.D., professor, medicine, Oregon Health & Science University, Portland; Nov. 1, 2007, Journal of Clinical Investigation


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 27, 2017 , ... Robert E. Burke, MD, PhD, had a ... impoverished upbringing and life experiences could have led him down a much different path. ... Tales of Parenting, Perseverance and Pediatrics,” Dr. Burke shares a personal account of the ...
(Date:2/27/2017)... ... February 27, 2017 , ... Elisa Guajardo Carothers is not your typical author. She ... to become a nun. Now, she writes about God, when she isn’t swimming as a ... and AD, Here is BS! (Before Satan),” she offers a comedic look at the dysfunctions ...
(Date:2/27/2017)... ... February 27, 2017 , ... POUGHKEEPSIE, N. Y. – Peer-reviewed guidelines from ... scientific studies, the Center for Disease Control ( CDC ) and Infectious Diseases Society ... B. Liegner, M.D. has compiled into a single volume a compelling argument that the ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair ... to announce an upgrade to the company's Yelp listing. Bay Area residents struggling ... as diverse as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as ...
(Date:2/26/2017)... , ... February 26, 2017 , ... ... 2011 the lab became the world’s first to be ISO/IEC 17025:2005 INAB accredited ... allergen) analysis. , ISO/IEC 17025:2005 is the globally recognised standard that sets out ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... The Netherlands , Feb 27, 2017 ... is approved by NATO for use at the security ... security imposed within the NATO organization for the communication of ... ... providing government authorities with an eavesdrop-secure smartphone solution. Sectra Tiger/R ...
(Date:2/24/2017)... February 24, 2017 Following receiving ... Israel , s AMAR is a major ... 250 M w ound care market in ... BST for inclusion in the National Health Basket ...   E-QURE Corp. (OTCQB: EQUR), a leader ...
(Date:2/24/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... present at the Cowen and Company 37 th ... Place on Tuesday, March 7, 2017 at 11:20 a.m. ... the presentation can be accessed at http://wsw.com/webcast/cowen38/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
Breaking Medicine Technology: