Navigation Links
Study: Some pancreatic cancer treatments may be going after the wrong targets
Date:5/22/2014

ANN ARBOR, Mich. New research represents a significant change in the understanding of how pancreatic cancer grows and how it might be defeated.

Unlike other types of cancer, pancreatic cancer produces a lot of scar tissue and inflammation. For years, researchers believed that this scar tissue, called desmoplasia, helped the tumor grow, and they've designed treatments to attack this.

But new research led by Andrew D. Rhim, M.D., from the University of Michigan Comprehensive Cancer Center, finds that when you eliminate desmoplasia, tumors grow even more quickly and aggressively. In the study, mice in which the desmoplasia was eliminated developed tumors earlier and died sooner.

"This flies in the face of 10 years of research," says Rhim, assistant professor of gastroenterology at the U-M Medical School. "It turns out that desmoplasia is a lot more complex than previously thought. Components of this complex scar tissue may be the body's natural defense against this cancer, acting as a barrier or fence to constrain cancer cells from growing and spreading. Researchers who have been trying to target desmoplasia to kill tumors may need to reevaluate their approach."

Several drugs targeting desmoplasia are in clinical trials and one was recently stopped early because of poor results. "Our study explains why this didn't work," Rhim says.

The researchers were able to arrive at this surprising conclusion by using a better mouse model. Previous models have used mice with compromised immune systems injected with human pancreatic cancer cells, producing tumors that don't closely resemble human pancreatic cancer. The current model utilizes mice that are genetically engineered to express the two most common genetic mutations seen in pancreatic cancer. The mice developed cancer spontaneously, and the cancer closely resembled human pancreatic cancer.

Results of the study appear in Cancer Cell. The work represents a
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.ed
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
2. Study: Insomnia takes toll on tinnitus patients
3. Study: No link between depression, nasal obstruction
4. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
5. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
6. OHSU study: Misdiagnosis of MS is costing health system millions per year
7. UW study: Sleep apnea associated with higher mortality from cancer
8. Study: Heart damage after chemo linked to stress in cardiac cells
9. STeleR study: Telerehab improves functioning after stroke
10. Study: Willingness to be screened for dementia varies by age but not by sex, race or income
11. Study: 21 percent of newly admitted nursing home residents sustain a fall during their stay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... D.C. (PRWEB) October 22, 2014 With the ... a national survey by the American Institutes for Research (AIR) ... know how to use health insurance, but 42 percent say ... a plan’s details before signing up for coverage. , The ... with only 20 percent able to calculate correctly how much ...
(Date:10/22/2014)... Although there are only 24 hours in a ... who have trouble finding time within their busy schedules for exercise ... periods of time to get in shape. Here are five ways ... go. , Change Up Your Commute , Consider riding a ... some exercise into your daily routine. If you must use your ...
(Date:10/22/2014)... Salamon HealthDay Reporter , TUESDAY, ... vitro fertilization (IVF) are only about half as likely as ... technique, new research indicates, and the racial disparity persists even ... 31 percent of white patients became pregnant after IVF, compared ... than 4,000 IVF cycles over two years to tease out ...
(Date:10/22/2014)... Dennis Thompson HealthDay ... U.S. health officials on Monday officially tightened guidelines for health ... no skin exposure and use of a respirator at all ... decided to issue the tougher rules after two Dallas nurses ... in the United States, Liberian national Thomas Eric Duncan. Nina ...
(Date:10/20/2014)... Wakefield, MA (PRWEB) October 20, 2014 ... be sponsoring a booth at the American Foundation for ... October 25th. The AFSP is a not-for-profit organization that ... year. Net proceeds from these events are used to ... research, but education and personal relationships as well. ...
Breaking Medicine News(10 mins):Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... single-source solution for leading medical destinations, doctors and treatment packages ... ... Patients Beyond Borders, one of the most recognized names in the ... healthcare overseas, has agreed to be a content partner for ...
... was named a Finalist in the 2009 American Business Awards for ... ... FL (PRWEB) May 26, 2009 -- The American Business Awards are ... U.S.A. are eligible to submit entries to the ABAs - public ...
... range of industries like WLAN networks, telecommunication, wireless ... science experiments, traffic control & Audio/Video, Pro-cell antenna-related ... participate in the Taipei World Trade Exhibition -- ... in the world, next only to CeBIT in ...
... with a leading global manufacturer of resuscitation devices. With this agreement, ... system at a future date. , ... Jerusalem/Needham, MA ... Swiss Exchange: ORIDN) today announced that it signed an OEM agreement ...
... for a time, but bounce back, , , MONDAY, May 25 ... have long claimed: Memory and learning take a hit during ... issue of Neurology finds that women do not ... are irregular but have not disappeared altogether. , But the ...
... Review of trials finds Avastin with chemo doubles odds ... use of the drug bevacizumab (Avastin) in combination with ... cancer patients, new research has found. , These perforations ... stomach, small intestine or large bowel. , Bevacizumab is ...
Cached Medicine News:Health News:Medeguide and Patients Beyond Borders Collaborate to Feature Global Healthcare Options Online 2Health News:iHealthSpot, Inc Named as Finalist in American Business Awards(sm) 7th Annual Stevie Awards will be Presented on June 22 in New York City 2Health News:iHealthSpot, Inc Named as Finalist in American Business Awards(sm) 7th Annual Stevie Awards will be Presented on June 22 in New York City 3Health News:Pro-cell Announces a Knock at the Door of Emerging Markets 2Health News:Pro-cell Announces a Knock at the Door of Emerging Markets 3Health News:Pro-cell Announces a Knock at the Door of Emerging Markets 4Health News:Oridion Expands its Presence in the Pre-hospital Market with an OEM Partnership with a leading Defibrillator Manufacturer 2Health News:Oridion Expands its Presence in the Pre-hospital Market with an OEM Partnership with a leading Defibrillator Manufacturer 3Health News:Oridion Expands its Presence in the Pre-hospital Market with an OEM Partnership with a leading Defibrillator Manufacturer 4Health News:Memory Takes a Hit During Menopause 2Health News:Memory Takes a Hit During Menopause 3Health News:Cancer Drug May Boost Risk of Gastrointestinal Perforation 2
(Date:10/22/2014)... FAIRFIELD, N.J. , Oct. 22, 2014 /PRNewswire/ ... a major transformation in the pain market, according ... Pain Insights, Inc., a firm providing market research ... management. Photo - http://photos.prnewswire.com/prnh/20141021/153440 ... a scheduling change for hydrocodone combination products from ...
(Date:10/22/2014)... , Oct. 22, 2014   Reproductive ... world-renowned leader in the field of infertility, presents ... to embryonic screening. The research abstract, released during ... Reproductive Medicine (ASRM) meeting in Honolulu, ... and single gene defect (SGD) pre-implantation genetic diagnosis ...
(Date:10/22/2014)... 22, 2014  CryoLife, Inc. (NYSE: CRY ... focused on cardiac and vascular surgery, announced today that ... Executive Officer, has been elected to the Company,s Board ... Steven G. Anderson , Executive Chairman of CryoLife, stated, "Since ... be an excellent leader who is well positioned to ...
Breaking Medicine Technology:Hydrocodone: Rescheduled, Repositioned & Reinvented 2Hydrocodone: Rescheduled, Repositioned & Reinvented 3New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... Oct. 28 Physicians from Reproductive Medicine Associates ... research award, the 2010 General Program Prize, from ... "A Prospective Randomized Controlled Trial Demonstrating Significantly Increased ... and Analysis on Day 5 with Fresh Transfer," ...
... 28 In honor of November,s Diabetes Awareness Month and ... country music recording artist and Nashville Star finalist, ... Angels" in the U.S. and offer a special gift – ... in support of the Juvenile Diabetes Research Foundation ...
Cached Medicine Technology:Reproductive Medicine Associates of NJ Receive Top National Award for Ground-Breaking IVF Research 2Reproductive Medicine Associates of NJ Receive Top National Award for Ground-Breaking IVF Research 3Reproductive Medicine Associates of NJ Receive Top National Award for Ground-Breaking IVF Research 4Country Music Star Teams up with JDRF to Inspire Kids With Diabetes and Raise Money for Research 2Country Music Star Teams up with JDRF to Inspire Kids With Diabetes and Raise Money for Research 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: