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Study: Research reveals protective properties of influenza vaccines
Date:3/25/2013

e administration of a flu vaccine in all groups, stimulated T cells were evident, contributing to the development of the immune response.

The T cells positively correlated with increased antibodies against each flu virus strain examined, with the exception in the children's group against the swine-origin H1N1 virus.

"Given that seasonal influenza vaccines induce antibody responses mainly through boosting the recall response of the immune system, this lack of correlation might reflect the lack of H1N1 specific immunity in some children," explains study co-author Emilio Flano, PhD, a principal investigator in the Center for Vaccines and Immunity at Nationwide Children's and an associate professor of Pediatrics at OSU College of Medicine.

"This is consistent with the fact that these children had not been vaccinated or naturally exposed to the H1N1 virus prior to being vaccinated during the 2010-2011 winter," said study co-author Santiago Lopez, MD, a postdoctoral research fellow in the Center for Vaccines and Immunity and a resident at Nationwide Children's.

Further experiments demonstrated that this unique subset of helper T cells can boost production of existing antibodies that fight flu by stimulating memory B cells, but do not help production of new antibodies by nave B cells.

"We're gratified that our study provides evidence of one of the essential events associated with the immune response following seasonal influenza vaccination," says Dr. Ramilo. "Understanding these processes is a key step toward developing more effective vaccines."


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Contact: Mary Ellen Peacock
maryellen.peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

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