Navigation Links
Study: Repeated surgeries appear to extend life of patients with deadliest of brain cancers
Date:10/31/2012

People who undergo repeated surgeries to remove glioblastomas the most aggressive and deadliest type of brain tumors may survive longer than those who have just a one-time operation, new Johns Hopkins research suggests.

Glioblastoma, the brain cancer that killed Sen. Edward Kennedy, inevitably returns after tumor-removal surgery, chemotherapy, and/or radiation. The median survival time after diagnosis is only 14 months. With recurrence a near certainty, experts say, many have questioned the value of performing second, third or even fourth operations, especially given the dangers of brain surgery, including the risk of neurological injury or death.

"We are reluctant to operate on patients with brain cancer multiple times as we are afraid to incur new neurological deficits or poor wound healing, and many times we are pessimistic about the survival chances of these patients," says Alfredo Quinones-Hinojosa, M.D., a professor of neurosurgery at the Johns Hopkins University School of Medicine and leader of the study published recently in the Journal of Neurosurgery. "But this study tells us that the more we operate, the longer they may survive. We should not give up on these patients."

For the study, Quinones-Hinojosa and his team reviewed the records of 578 patients who underwent surgery to remove a glioblastoma between 1997 and 2007 at The Johns Hopkins Hospital. At the last follow-up, 354 patients had one surgery, 168 had two resections, and 41 and 15 patients had three and four operations, respectively. The median survival for patients who underwent one, two, three and four operations was 6.8 months, 15.5 months, 22.4 months and 26.6 months, respectively.

Quinones-Hinojosa cautions that his analysis may overestimate the value of multiple surgeries based on patient selection, and that it's possible that the patients who did better had tumors with a biology that predisposed them to live longer. Further research will need to confirm his more positive conclusion.

Glioblastomas are cancerous tumors that become deeply intertwined with healthy brain tissue and, as a result, are difficult to remove. They are notoriously difficult to eradicate with surgery alone. "The only thing that has been proven to work for glioblastoma throughout history is surgery," Quinones-Hinojosa says. "Without surgery, these patients don't have much of a chance."

Along with reducing the size of tumors, repeated surgeries may also increase the efficacy of radiation and chemotherapy.

Quinones-Hinojosa says with each successive surgery, the procedure itself becomes more technically challenging as the anatomy changes, blood vessels are damaged and tissues become frail.

Patients, their families and their doctors must determine whether repeated surgery is the best course of action, weighing the potential risks against the potential benefits, Quinones-Hinojosa says. The procedure should only be done if it can be done relatively safely and patients can tolerate anesthesia and the long recovery period.


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Related medicine news :

1. Study: Use of antipsychotic drugs improves life expectancy for individuals with schizophrenia
2. Study: No Long-Term Heart Risks From Breast Radiation
3. Study: Gingko biloba does not improve cognition in MS patients
4. BYU study: Exercise may affect food motivation
5. University of Maryland study: Neonatal heart stem cells may help mend kids broken hearts
6. Study: Married lung cancer patients survive longer than single patients after treatment
7. Mayo study: Exercise can help cancer patients, but few oncologists suggest it
8. Study: Clot removal devices successful tools for acute ischemic stroke treatment
9. Study: College students lose respect for peers who hook up too much
10. Study: Vaccine targets malignant brain cancer antigens, significantly lengthens survival
11. Study: Majority of older, early-stage breast cancer patients benefit from radiation after lumpectomy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... Helena, AL (PRWEB) , ... July 21, 2017 ... ... that offers insurance assistance and financial planning services to communities in the greater ... that promises to provide resources to underprivileged young people in the region. , ...
(Date:7/21/2017)... ONTARIO, CANADA (PRWEB) , ... July 21, 2017 , ... ... IL and Past President of the American Orthopaedic Society of Sports Medicine (AOSSM) ... 21, 2017 during the AOSSM Annual Meeting in Toronto, Canada. This prestigious award is ...
(Date:7/21/2017)... ... July 21, 2017 , ... “Kids aren't born knowing how to regulate their ... Suzanne Tucker, Founder of St. Louis-based positive education company Generation Mindful. To help with ... Monday, July 21st. , The kit uses colorful, engaging and educational illustrations and ...
(Date:7/21/2017)... ... July 21, 2017 , ... How ... are on the rise, say researchers presenting their work at the American ... , “The combination of evaluating the patterns of change in concussion symptom presentation, ...
(Date:7/20/2017)... ... July 20, 2017 , ... Coats ... is pleased to announce their expansion to the Midwest with the establishment of ... Hollis and Ronald Bell, and of counsels, John Peck and Robert Bruns, will ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... RK Logistics Group, Inc. was awarded ... Fremont, CA headquarters facility where it ... San Jose for hi-tech, pharmaceutical and ... , with its Fremont Innovation District, is excited to strategically ... resource to the hundreds of biotech, pharma and biomed companies ...
(Date:7/11/2017)... 11, 2017 Zymo Research Corp., also known as ,The Epigenetics ... biological aging in a precise manner using the myDNAge ™ test. ... a professor of human genetics and biostatistics at the David Geffen ... Health , Zymo Research,s proprietary DNAge ™ technology is used to ... ...
(Date:7/11/2017)... , July 11, 2017  Dr. Echenberg, founder of Echenberg Institute, is ... to patients who suffer from painful intercourse and other painful pelvic pain ... atrophy due to menopause. ... VuVatech LLC ... by Sarasota, Florida -based start-up company, VuVatech LLC, fills ...
Breaking Medicine Technology: