Navigation Links
Study: Redefining the criteria for ALK positive lung cancer
Date:9/10/2013

oint fell in a clear gap between tumors that were obviously ALK-positive and tumors that were obviously ALK-negative, making it an attractive threshold.

"But what this study shows is that when you look not at tens, but hundreds of cases, tumors clearly exist that come right up to the 15-percent cutoff point," Camidge says.

Another possible gray area is when a gene rearrangement occurs but is very complex like shuffling cards rather than just cutting the deck. In this situation the typical separated dot pattern indicative of ALK rearrangement may not be present, but instead doublets or triplets of single or un-separated dots may exist. This atypical cellular footprint can tell an expert that, while officially ALK-negative, the cancer has made some changes in the region of the ALK gene that could still make the cancer sensitive to ALK-inhibitor drugs.

"We believe these data suggest that such borderline and atypical negative cases deserve a closer look, perhaps with new kinds of diagnostic tests," Says Camidge.

The current study tested 1426 samples of non-small cell lung cancer, which included 174 officially positive for an ALK rearrangement and 1252 that were officially negative. Of the ALK-negative tumors, 121 had greater than 10 percent ALK-positivity, but were still below the 15 percent needed to classify the overall tumor as ALK-positive. This means that 8.5 percent of non-small cell lung cancers were "borderline" negative. In the study, 1-2 percent also showed atypical-negative patterns, a group that may also benefit from a closer re-evaluation of their ALK status.

Early in 2013, serendipity provided a chance to test whether at least one of the Colorado team's hypotheses were correct. In a case described in an upcoming article in the Journal of Thoracic Oncology, Dr. Shengxiang Ren from the Shanghai Pulmonary Hospital describes a patient who traveled halfway across the world for a second opinion at the University of Colorado, whe
'/>"/>

Contact: Erika Matich
erika.matich@comcast.net
303-724-1528
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. ACR, SBI on cancer study: More breast cancer screening needed in younger women
2. Study: Disease caused by repeat brain trauma in athletes may affect memory, mood, behavior
3. Study: Many evangelicals are ambivalent about homosexuality and civil unions for gays
4. Study: Heart pump with behind-the-ear power connector
5. Study: Centers throughout the brain work together to make reading possible
6. Study: Taxing sugary beverages not a clear cut strategy to reduce obesity
7. Study: Taxing Sugary Beverages Not a Clear Cut Strategy to Reduce Obesity
8. Study: EBV Mononucleosis Risk Increased by Smoking and Family Size; polyDNA Recommends Gene-Eden-VIR Against the Latent EBV
9. New Study: Alcohol Drinkers May Face Long Term Health Issues
10. Beaumont Study: Nerve Stimulation Helps with Overactive Bladder
11. Study: Ipilimumab Shows Durable Responses But Low Overall Response Rate In Patients With Unresectable Or Metastatic Mucosal Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... 24, 2015 ... - The students were selected ... the fourth annual A Day of ... Geneva National in Lake Geneva. , ... High School,         Jonathan Alfonso,         Bridget Keefe, ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 With the ... businesses, are finding it increasingly difficult to provide their ... fail to provide adequate insurance for employees stand to ... been such an integral part of a business’s success ... healthcare for businesses, Online USA Doctors has created a ...
(Date:5/23/2015)... Javon Bea Mercy Health System CEO ... Center, 557 N. Washington St., Janesville, will host an ... pm. , The 8-week clinic is lead by Brent ... who will offer training that encompasses a warm-up, training ... show selection and weekly training plans. , The program ...
(Date:5/22/2015)... The American College of Traditional Chinese ... They will hold a webinar on the updates of ... on Classical Chinese Medicine. , Webinar – First Professional ... the Dean of Clinical Education, will lead this webinar ... Doctorate program. ACTCM is currently developing this degree program ...
(Date:5/22/2015)... May 22, 2015 Omar Ahmad Barrada, ... to participate in the 2015 Congress of Future Medical ... as a gathering of “America’s highest achieving high school ... of healthcare, set new goals and learn better study ... live surgery, during which we can ask the surgeons ...
Breaking Medicine News(10 mins):Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:ACTCM Announces Upcoming June Events 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2
... Amanda Gardner HealthDay Reporter , TUESDAY, Nov. 16 ... defective one, scientists were able to partially restore the heart,s ... "This is the first time gene therapy has been ... heart failure," study lead author Dr. Donna Mancini, professor of ...
... prescription filled can undermine medical treatment, result in increased ... the patient. An editorial in the Nov. 16 issue ... the problem and issues a call to action. ... Nonadherence," Michael D. Murray, PharmD, MPH, a Regenstrief Institute, ...
... HealthDay Reporter , MONDAY, Nov. 15 (HealthDay News) ... those involved: Sometimes surgical instruments and sponges are left inside ... Children suffering from such mishaps were not more likely ... are more than twice as long and cost more than ...
... 1 and 1-1/2, children who get most of their sleep at ... variety of skill areas than children who don,t sleep as much ... conducted by researchers at the University of Montreal and the University ... the journal Child Development . The study, of 60 ...
... cancer appear more likely to experience hearing loss and to ... not receive such treatment, according to a report in the ... , one of the JAMA/Archives journals. Head and neck ... according to background information in the article. Treatment methods include ...
... MONDAY, Nov. 15 (HealthDay News) -- In Australia, where universal ... much more prevalent among poor citizens than it is among ... researchers say that differences in risk do exist between the ... heart disease is typically thought of as more prevalent in ...
Cached Medicine News:Health News:Gene Therapy Shows Potential Against Heart Failure 2Health News:Not following doctor's orders: Prescription abandonment 2Health News:Sponges, Surgical Tools Sometimes Left in Kids After Operation 2Health News:Sponges, Surgical Tools Sometimes Left in Kids After Operation 3Health News:Nighttime sleep found beneficial to infants' skills 2Health News:Hearing loss common following radiation therapy for head and neck cancer 2Health News:Universal Health Care May Lessen Income's Impact on Heart Disease 2
(Date:5/22/2015)... , May 22, 2015  The Mesothelioma Victims ... victims of mesothelioma get the best possible compensation, ... individuals with this rare cancer caused by exposure ... up-to-date information related to treatment options such as ... call the Mesothelioma Victims Center anytime at 866-714-6466. ...
(Date:5/22/2015)... 20, 2015 Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ... "Guide to Prepare Application Dossiers for Oversea Medical ... " report to their offering. ... segment market of the most growth potentiality, which ... manufacturers and producers to penetrate such market. It ...
(Date:5/22/2015)... , May 22, 2015 Research and Markets ... addition of the "Latest Regulations on Pharmaceutical ... to their offering. This is first ... a guidance on international multi-center clinical trials of ... has begun to be implemented on March 1, ...
Breaking Medicine Technology:Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 32015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... DIEGO, April 14, 2011 LifeVantage Corporation (OTCBB: ... preliminary net revenue for its third fiscal quarter of 2011 ... $2.6 million or 35% over net revenue of $7.4 million ... is also an approximate $7.3 million or 270% increase in ...
... Attorney General Roy Cooper warned the House Special Select ... immunity to pharmaceutical companies could cost North Carolina taxpayers ... dollars." Still, the GOP-controlled committee, led by ... could go to the House floor for a vote ...
Cached Medicine Technology:LifeVantage Announces Preliminary Third Quarter 2011 Revenue 2GOP's Big Pharma Protection to Cost NC Taxpayers "Hundreds of Millions" 2
... Catheter is indicated for balloon ... of a coronary artery or ... purpose of improving myocardial perfusion. ... also designed to provide distal ...
16mm from Mid-screw to Tips, blunt tips; overall length 110mm; Stainless Steel...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right; ) overall length 120mm; Stainless ...
Two prong stainless steel tips; with titanium handle/...
Medicine Products: