Navigation Links
Study: Obesity limits effectiveness of flu vaccines
Date:10/25/2011

months compared to one month post vaccination. However, less than 25 percent of healthy weight participants had a four-fold decrease in antibody levels.

Also, when study participants' blood samples were tested in the lab and exposed to a flu virus 11 months after vaccination, about 75 percent of healthy weight people's CD8+ T cells still expressed interferon-γ, an infection-fighting protein. However, only about 25 percent of obese patients' cells responded by producing the protein.

When vaccination fails to prevent flu infection, people must rely in part on their CD8+ T cells to limit the spread and severity of infection, said Patricia Sheridan, Ph.D., research assistant professor of nutrition and an author on the paper.

"If antibody titers are not maintained over time in the obese individuals and memory CD+ T cell function is impaired, they may be greater risk of becoming ill from influenza," Sheridan said.

Heather Paich, a doctoral student in Beck's lab, added: "The findings also suggest overweight and obese people are more likely to become sicker and have more complications. That's because influenza-specific CD8+ T cells do not protect against infection, but instead act to limit the disease's progression and severity of disease."

In 2005, Beck and her colleagues reported that obesity in mice impaired the animals' ability to fight influenza infections and increased the percent dying from influenza, compared to lean mice with the same infections. In 2010, her team showed that obesity seemed to limit the mice's ability to develop immunity to influenza, suggesting vaccines may not be as effective in obese and overweight as in healthy weight humans. Also, the fatality rate was higher in obese mice none of the lean mice died, but 25 percent of the obese mice died.

"This latest study shows that obese people may have a similar impaired response to influenza vaccines as our mouse models did to influenza virus,
'/>"/>

Contact: Ramona Dubose
ramona_dubose@unc.edu
919-966-7467
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mayo Clinic study: PSA test valuable in predicting biopsy need, low-risk prostate cancer
2. Rochester study: Age a big factor in prostate cancer deaths
3. Virginia Commonwealth University study: We are what we experience
4. Mayo Clinic study: multiple surgeries and anesthesia exposure
5. Study: Overweight older women have less leg strength, power
6. Study: No link betweem menopause and increased risk of fatal heart
7. Study: 85 percent of homeless people have chronic health conditions
8. Study: Afghan patients a common source of drug-resistant bacteria
9. Study: Community organization can reduce, negate impact of alcohol outlets on neighborhood violence
10. Study: Graphic warning labels reduce demand for cigarettes
11. Study: Inexpensive method detects ALK rearrangement in lung cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... revitalized and expanded through a U.S.-funded effort that ... access and providing cutting-edge skills labs and other ... by participants of the $130 million Medical Education ... progress being made at the African institutions. Their ... by the journal Academic Medicine . Begun ...
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July 30, 2014 ... least 2,000 Americans die from extreme heat or cold, floods ... stroke or sun stroke caused nearly one-third of more than ... the U.S. Centers for Disease Control and Prevention. Cold ... -- accounted for 63 percent of those weather-related deaths. The ...
(Date:7/30/2014)... SF Cable, distributor of the highest quality cables, ... internet with guaranteed customer satisfaction announces the availability of ... These lightning cords are MFI certified to meet Apple ... Cable Lightning to USB Cables feature the ... and syncing. Compatible with the iPhone 5S/5C/5 plus iPad ...
(Date:7/30/2014)... 30, 2014 Visitors to our region ... $8,500 to ensure its protection. Bob Kiesendahl, one of ... to the Delaware Highlands Conservancy for donations collected through ... $2-per-stay donations add up fast, as visitors welcome the ... Delaware River Region. , The Kiesendahl family has owned ...
(Date:7/30/2014)... DRE Medical — a leading medical equipment ... its Medical Trade Shows & Conventions Calendar Schedule ... equipment vendors. , The calendar is a continually-updating guide ... States and around the world. Hundreds of entries are ... always growing. , Information listed on each trade show ...
Breaking Medicine News(10 mins):Health News:Journal supplement details progress in African medical education 2Health News:Journal supplement details progress in African medical education 3Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 2Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 3Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:DRE Launches Online Interactive Medical Trade Show Calendar 2
... Ensign Group, Inc. (Nasdaq: ENSG ), the parent company of the Ensign™ ... that its Board of Directors has declared a quarterly cash dividend of ... April 30, 2010 to shareholders of record as of March 31, ... ...
... March 15 Centocor Ortho Biotech Products has informed PharmaMar SA (Grupo Zeltia, ... have approved Yondelis(R) for advanced soft tissue sarcoma (STS) in adults. Furthermore, the authorities ... ovarian cancer (ROC). Yondelis is already approved for STS in Paraguay and ... ...
... Spotlighting the importance of oral health care for expectant mothers, the California Dental Association (CDA) Foundation has released new guidelines designed to emphasize the safety of dental treatment during ... ... ... ...
... at the University of Minnesota Medical School have discovered ... the hearts of Duchenne muscular dystrophy patients a ... children. The chemical, which Medical School scientists have termed ... heart muscle. When injected into the bloodstream, the molecular ...
... aspects of March Madness, offer tips to temper drawbacks , ... , , ... ... CHICAGO , March 15 ...
... ON , March 15 /PRNewswire-FirstCall/ - Nuvo Research ... the research and development of drug products that are delivered ... drug delivery technologies, and on the development of its immune ... the first patient in its European Phase 2 clinical trial ...
Cached Medicine News:Health News:The Ensign Group Declares Quarterly Dividend 2Health News:Yondelis(R) Receives Five New Approvals Outside the European Economic Area 2Health News:Yondelis(R) Receives Five New Approvals Outside the European Economic Area 3Health News:Yondelis(R) Receives Five New Approvals Outside the European Economic Area 4Health News:California Dental Association Foundation Releases New Oral Health Guidelines for Pregnant Women 2Health News:California Dental Association Foundation Releases New Oral Health Guidelines for Pregnant Women 3Health News:California Dental Association Foundation Releases New Oral Health Guidelines for Pregnant Women 4Health News:Researchers discover chemical that may protect hearts of muscular dystrophy patients 2Health News:Experts Say It's Not So Bad to Go a Little Mad 2Health News:Experts Say It's Not So Bad to Go a Little Mad 3Health News:Experts Say It's Not So Bad to Go a Little Mad 4Health News:Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial 2Health News:Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial 3Health News:Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial 4Health News:Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial 5
(Date:7/30/2014)... and PARIS , July ... REGN ) and Sanofi (EURONEXT: SAN and NYSE: ... 3 ODYSSEY trials of alirocumab in people with hypercholesterolemia ... reduction from baseline in low-density lipoprotein cholesterol (LDL-C) at ... is an investigational monoclonal antibody targeting PCSK9 (proprotein convertase ...
(Date:7/30/2014)... and NEW YORK , July 30, ... developer of new products for oncology supportive care, announced ... , has been featured in an article on OncLive.com ... in Head and Neck Cancers."  Dr. Steve Sonis ... on the growing demand seen in the oncology community ...
(Date:7/30/2014)... ANTONIO , July 30, 2014   ... company focused on innovating lifesaving devices and methods ... $4.5 million in Series A financing, which was ... Proceeds from the deal will allow Bluegrass Vascular ... Access Catheter System, enhance manufacturing capabilities, and proceed ...
Breaking Medicine Technology:Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 2Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 3Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 4Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 5Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 6Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 7Regeneron and Sanofi Report Positive Top-Line Results from Nine Phase 3 Trials of Alirocumab in People with Hypercholesterolemia 8Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Bluegrass Vascular Technologies Raises $4.5M Series A Financing Led By Targeted Technology Funds 2
... 12, 2007 - CombinatoRx,Incorporated (NASDAQ: CRXX), today ... efforts will be presented at the 98th,Annual ... Research,April 14-18, 2007 in Los Angeles, CA., ... Therapy", Heilbut, et.al. (Abstract #1410) will be ...
... Oncology Portfolio, SOUTH SAN FRANCISCO, Calif., April ... the presentation of four research projects aimed ... as,potential therapeutics for certain types of cancers ... presentations during,poster sessions from April 16th to ...
Cached Medicine Technology:CombinatoRx to Present Combination High Throughput Screening (cHTS),Data at Upcoming AACR Meeting 2CombinatoRx to Present Combination High Throughput Screening (cHTS),Data at Upcoming AACR Meeting 3Rigel to Present New Research Programs at AACR Meeting 2Rigel to Present New Research Programs at AACR Meeting 3Rigel to Present New Research Programs at AACR Meeting 4Rigel to Present New Research Programs at AACR Meeting 5
1.0 mm diameter head, 0.75 mm deep bite....
Target illumination for day and night testing. Glare luminance distance. The Optec 3500 remote control offers flexible positioning during test administration. Each vision tester includes 12 tests sli...
Stainless steel flexible ruler. graduated in 1/32 inches (.8 mm) fractions, as well as mm graduations....
Colorado Microneedles offer the surgeon precision in cutting and coagulation, without the expense and inconvenience of a laser. The needles may also be used for dissecting large areas such as the sca...
Medicine Products: