Navigation Links
Study: Majority of older, early-stage breast cancer patients benefit from radiation after lumpectomy
Date:8/12/2012

HOUSTON For the majority of older, early-stage breast cancer patients, radiation therapy following breast conserving surgery may help prevent the need for a later mastectomy, according to research from The University of Texas MD Anderson Cancer Center.

The findings, published in the journal Cancer, are contrary to current national treatment guidelines, which recommend that older women with early stage, estrogen-positive disease be treated with lumpectomy followed by estrogen blocker therapy alone -- and forgo radiation therapy post-surgery.

The potential benefit of radiation in this patient population has been the focus of much research over the past decade, said Benjamin Smith, M.D., assistant professor in the Department of Radiation Therapy at MD Anderson and the study's corresponding author.

In 2004, a major study found that women who received tamoxifen alone, compared to tamoxifen and six weeks of radiation, had a slightly higher incidence of breast cancer recurrence. Yet, there was no difference in mastectomy rates or survival among the two cohorts, said Smith. Based on these findings, the NCCN adjusted its treatment guidelines, and radiation therapy following lumpectomy was no longer recommended. Smith then followed up this guideline-changing research with a population-based study, confirming the earlier findings with respect to breast cancer recurrence.

"The motivation for this new research was to do a similarly designed study with longer term follow up," said Smith. "We wanted to do a 10-year update, focusing specifically on the mastectomy question. The fundamental reason it was determined that women didn't need radiation was because the additional therapy did not change mastectomy rates."

For the population-based study, Smith and his colleagues derived a cohort of Medicare patients from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) registry who would have been eligible for the 2004 study. The researchers identified 7,403 patients ages 70-79 treated with a lumpectomy for early-stage estrogen-positive breast cancer. All were diagnosed between 1992 and 2002, with follow up through 2007. Of the 7,403 women, 88 percent received radiation after their lumpectomy.

Within 10 years of their treatment, 6.3 percent of the women who did not receive radiation therapy had a mastectomy, likely because of a breast cancer recurrence, says Smith, compared to 3.2 percent who had the additional treatment. In patients with high-grade tumors, regardless of other factors such as age and/or tumor characteristics, radiation seemed to be highly beneficial.

The researchers also found a subset of women for whom radiation did not benefit, and thus could be omitted from care regimen: those 75- 79 years of age who had their lymph nodes assessed and did not have high-grade tumors.

"I think the national guidelines, while well intended and important, may gloss over the certain nuances needed for making critical decisions with patients," said Smith. "Our study may shed additional light on some of those nuances and provides data that physicians can use when talking to their patients about whether to go forward with radiation. Personally, having this data point, together with the previous findings, gives me the confidence to not routinely recommend radiation in women age 75 and over with non-high grade tumors."
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Rhode Island Hospital study: Bariatric patients with obstructive sleep apnea fail to show symptoms
2. Study: Methodology of determining financial viability of social security
3. Study: Group yoga improves motor function and balance long after stroke
4. Rutgers study: Anxiety disorders in poor moms likely to result from poverty, not mental illness
5. New study: Elderly Medicare beneficiaries most satisfied with their health insurance
6. Study: Children abused by parents face increased cancer risk
7. Study: Kids with behavior problems, disabilities bullied more, more likely to bully others
8. Study: 21 percent of newly admitted nursing home residents sustain a fall during their stay
9. Study: Willingness to be screened for dementia varies by age but not by sex, race or income
10. STeleR study: Telerehab improves functioning after stroke
11. Study: Heart damage after chemo linked to stress in cardiac cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... ... 12, 2017 , ... HMP , a leader in healthcare events and ... Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie ... annual award competition recognizes editorial and design excellence across a range of sectors. This ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the ... – Miles by Moonlight to raise money for the American Heart Association Heart Walk. ... , Teams will work together to keep their treadmills moving for 5 hours. Treadmills ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
Breaking Medicine Technology: