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Study: Ipilimumab Shows Durable Responses But Low Overall Response Rate In Patients With Unresectable Or Metastatic Mucosal Melanoma
Date:5/28/2013

Durham, NC (PRWEB) May 28, 2013

Treatment with ipilimumab can result in durable antitumor effects despite a low overall response rate in patients with advanced mucosal melanoma (MM). Richard D. Carvajal, MD, Medical Oncologist at the Memorial Sloan-Kettering Cancer Center in New York, led the multicenter, retrospective study, recently published in The Oncologist, in collaboration with researchers from the Dana-Farber Cancer Institute and Massachusetts General Hospital in Boston.

Melanoma arising from the mucosal surfaces is a rare form of melanoma that differs clinically and biologically from cutaneous melanoma and is associated with a poor prognosis. To date, no prospective trials for patients with MM have been published, and the most effective systemic therapy has not been defined. Ipilimumab is currently a standard of care for patients with unresectable or metastatic melanoma, but its potential role in the treatment of patients with MM is unknown.

In the current study, researchers examined radiographic tumor response at 12 weeks, overall survival, and toxicity in 33 patients who received treatment with single-agent ipilimumab at one of the three participating institutions. All patients had unresectable or metastatic melanoma of primary mucosal origin, and 76% had received prior systemic therapy for metastatic disease. Twenty-five patients (76%) received a median of 4 doses of ipilimumab 3 mg/kg (range, 2 to 8 doses), and 24% received a median of 4 doses of ipilimumab 10 mg/kg (range, 2 to 17 doses). The most common immune-related adverse events were rash in 6 patients, diarrhea in 3 patients, and 1 case each of thyroiditis, hepatitis, and hypophysitis.

Among 30 evaluable patients, radiographic assessment at 12 weeks showed 1 complete response (CR), 1 partial response (PR), and 6 cases of stable disease. The overall response rate was 6.7%. The patient who achieved CR was aged 87 years at the time of i
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