Navigation Links
Study: Inherited Alzheimer's Detectable 20 Years Before Symptom Onset
Date:7/20/2011

WEDNESDAY, July 20 (HealthDay News) -- Inherited forms of Alzheimer's disease may be detectable up to two decades before problems with memory and thinking develop, according to new research.

The findings are significant because by the time dementia symptoms appear, the disease has severely damaged the brain, making it nearly impossible to restore a patient's mental abilities or memories, the study authors noted.

"We want to prevent damage and loss of brain cells by intervening early in the disease process -- even before outward symptoms are evident, because by then it may be too late," Dr. Randall Bateman, Alzheimer's researcher and physician at the Washington University School of Medicine in St. Louis and an associate director of the Dominantly Inherited Alzheimer's Network (DIAN), an international study of inherited forms of Alzheimer's, said in a university news release.

DIAN researchers are following members of families who have mutations in one of three genes: amyloid precursor protein; presenilin 1; or presenilin 2. People with these mutations will develop Alzheimer's disease early, between their 30s and their 50s, research has shown.

The age of disease onset among study participants could be predicted by referencing their parents. For instance, if a parent developed dementia at the age of 50 years, a child who inherited the mutation would be expected to develop dementia at roughly the same age. As a result, scientists are able to compile detailed chronologies of disease progression, covering the many years Alzheimer's is active in people's brains, although symptoms are not yet visible.

Initial results of the study confirm and expand on previous research, which suggested that certain changes in spinal fluid could be detected years before dementia.

"Based on what we see in our population, brain chemistry changes can be detected up to 20 years before the expected age of symptomatic onset," said Bateman. "These Alzheimer's-related changes can be specifically targeted for prevention trials in patients with inherited forms of Alzheimer's."

The researchers noted, however, clinical trials for the prevention of Alzheimer's among DIAN participants could carry risks.

"New treatments may have risks, so to treat patients prior to symptoms we must be sure that we have a firm grasp on who will develop Alzheimer's dementia," DIAN director Dr. John C. Morris, Harvey A. and Dorismae Hacker Friedman Professor of Neurology at Washington University, concluded in the news release. "If we can find a way to delay or prevent dementia symptoms in DIAN participants, that would be a tremendous success story and very helpful in our efforts to treat the much more common sporadic form of the illness."

The study was slated for presentation Wednesday at the Alzheimer's Association International Conference in Paris.

Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Institute on Aging has more on Alzheimer's disease genetics.

-- Mary Elizabeth Dallas

SOURCE: Washington University in St. Louis, news release, July 20, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study: Potassium Boosts Heart Health, Salt Harms It
2. Study: Hypoallergenic dogs not less allergic than other dogs
3. New study: Women less likely than men to fake soccer injuries
4. EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy
5. Rutgers study: Third of N.J. immigrant children, many adult newcomers lack health insurance
6. Study: Most parents unaware of teen workplace risks
7. Study: Long-term inhaled corticosteroid use increases fracture risk in lung disease patients
8. NEJM study: New drug represents breakthrough in treatment of hepatitis C
9. Pitt study: Gay, lesbian, bisexual youth bullied, abused more often than peers
10. Study: Trying to lose weight? Lose the fat substitutes
11. UF study: When singing mice choose a mate, a skillful song gets the gal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study: Inherited Alzheimer's Detectable 20 Years Before Symptom Onset 
(Date:4/29/2016)... ... 2016 , ... In an article published April 16th on the ... and lip injections, which she underwent in order to feel more at home at ... Festival. The article explains that Ms. Mirmelli’s situation is not unique; many plastic surgeons ...
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic ... the addition Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for brain ... mood optimization products to the store is just one more way Shamangelic Healing ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce is on ... security. Most importantly, employees are the single most important asset in creating value ... unhappy? , Just under half of American workers are emotionally checked out with ...
(Date:4/29/2016)... ... , ... Conditions were ideal for Global Lyme Alliance’s (GLA) 2nd annual “Bite ... a light breeze and temperatures in the 60s. Over 400 runners, walkers and volunteers ... and 1-mile walk were held to increase awareness about Lyme disease and to ...
(Date:4/29/2016)... ... April 29, 2016 , ... Spine Team Texas, a comprehensive spine physician ... one of their physicians has been invited to be a featured speaker at the ... Review conference on April 30, 2016. , Dr. R. Scott McPherson, a physical ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... Switzerland , April 27, 2016 ... AG announced the launch of a Phase 2 clinical ... residual hearing in patients undergoing cochlear implantation (CI) surgery. ... recruiting patients in Germany and ... into the middle ear at the time of surgery. ...
(Date:4/26/2016)... 26, 2016 Hill-Rom Holdings, Inc. (NYSE: ... at the Deutsche Bank 41 st Annual Health Care ... You are invited to listen to the live ... access it directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay ... of the live event and accessible at the links above ...
(Date:4/26/2016)... , April 27, 2016 Research ... "Global Molecular Diagnostics Market 2016-2020" report to their ... , ,The global molecular diagnostics market is projected to ... 2016-2020. Molecular diagnostics is a technique that ... the molecular level to detect changes in biochemical pathways. ...
Breaking Medicine Technology: