Navigation Links
Study: Inexpensive method detects ALK rearrangement in lung cancer patients
Date:8/2/2011

A relatively simple and inexpensive method may be used to determine whether a lung cancer patient is a candidate for crizotinib therapy, according to research published in the August issue of the Journal of Thoracic Oncology, the official monthly journal of the International Association for the Study of Lung Cancer (IASLC).

Lung cancer patients with ALK rearrangement have been found to respond well to crizotinib, an ALK inhibitor currently in clinical trials. Fluorescence in situ hybridization (FISH) has been considered the gold standard method for detecting ALK rearrangement.

"However, FISH requires a fluorescence microscope, and the signals are labile and rapidly fade over time," researchers wrote in the study, led by Jin-Haeng Chung, M.D., Ph.D., of Seoul National University Bundang Hospital in South Korea.

Researchers compared ALK rearrangement assessments using FISH and a newly developed method called chromogenic in situ hybridization (CISH). CISH allows detection of gene copy status using a conventional peroxidase-base reaction and standard bright field light microscope.

Out of a total 465 non-small cell lung cancer samples, ALK rearrangement was assessed using CISH in 449 patients (96.6%) and ALK rearrangement was identified in 18 patients (4%). Using FISH, ALK rearrangement was assessed in 453 patients (97.4%); ALK rearrangement was identified in 19 patients (4.2%). Among these cases, 443 cases (95.3%) had results matching the corresponding FISH results: 17 rearranged, 425 wild types, and 1 discordant case.

"There was high concordance in the assessment of ALK gene rearrangement between FISH and CISH techniques," researchers wrote.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. INFORMS study: OR models of hepatitis B prove decisive in treating millions in US, China
2. Study: Doctors differ in how best to care for Americas 12 million cancer survivors
3. Drexel study: Misuse of pain medication is pathway to high-risk behaviors
4. Study: Subsidizing wages at long-term care facilities would cut turnover
5. Study: Inherited Alzheimers Detectable 20 Years Before Symptom Onset
6. Study: Potassium Boosts Heart Health, Salt Harms It
7. Study: Hypoallergenic dogs not less allergic than other dogs
8. New study: Women less likely than men to fake soccer injuries
9. EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy
10. Rutgers study: Third of N.J. immigrant children, many adult newcomers lack health insurance
11. Study: Most parents unaware of teen workplace risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... treatment and variations in the quality of care are ... patients still varies widely between regions within Europe, according ... adults to date, published in The Lancet Oncology ... for most cancers of the blood has increased over ... of new targeted drugs in the early 2000s such ...
(Date:7/13/2014)... test for diagnosing type-1 diabetes could improve patient ... disease, according to the device,s inventors at the ... a paper to be published online July 13 ... nanotechnology to detect type-1 diabetes outside hospital settings. ... forms of diabetes mellitus, which are both characterized ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for ... wells as to maintain soil quality. The application of ... a dominant revenue generator for manufacturers in future. The ... costs has led to the adoption of micro irrigation ... caused massive demand for micro irrigation systems, as they ...
(Date:7/13/2014)... MarketsandMarkets recently conducted a study on the ... rendering; Layout and Animation; Image Reconstruction]: Global Advancements, ... analyzes and studies the major market drivers, restraints, ... Europe, Middle East and Africa, Asia-Pacific and Latin ... of the 3D imaging market, providing an in-depth ...
(Date:7/13/2014)... The federal court overseeing thousands of ... against Johnson & Johnson’s Ethicon, Inc. is preparing to ... to get underway next month. According to an Amended ... Southern District of West Virginia on July 9, 2014, ... 2014 at 3:00 p.m. July selection is slated to ...
Breaking Medicine News(10 mins):Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 2Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4
... Gribbin of Clarksburg, president and CEO of CentraState Healthcare ... the board of the New Jersey Hospital Association (NJHA), ... well as the appointment of new board members, was ... Regency Princeton. "Here in our state, the enormous problems ...
... A French study reported in the 12th January issue ... a strong correlation between blood pressure and outdoor temperature ... result, the investigators advise that, during periods of extreme ... "could contribute to reducing the consequences of blood pressure ...
... at National Jewish Health and the University of Colorado Denver ... among patients with acute lung injury. Acute lung injury (ALI) ... low oxygen levels in the blood, and fluid in the ... intensive care units, afflicting almost 200,000 people in the United ...
... As the health insurance market increasingly becomes consumer-driven, BlueCross ... shopping for insurance with face-to-face assistance at the company,s ... 23 in Mount Pleasant, S.C.Located at 615 Johnnie Dodds ... Shopping Center, the 1,800 square foot SC BlueStore(SM) ...
... BEAVERTON, Ore., Jan. 16 Includesdental.com announces ... for dentists, hygienists and other oral health ... to search for product reviews, clinical research, ... across thousands of sites."With Includesdental.com, dentists can ...
... severity among female patients., , , FRIDAY, Jan. 16 (HealthDay ... often and more severely than men, new research suggests. ... from around the world who had RA, about 79 ... had poorer outcomes in key measures such as symptoms ...
Cached Medicine News:Health News:Hospital Association Names New Chairman, Appoints Board Officers and New Members 2Health News:Seasonal variation in blood pressure 2Health News:Gene associated with reduced mortality from acute lung injury 2Health News:S.C. BlueCross to Open Its First Health Insurance Retail Store 2Health News:Includesdental.com Announces Search Engine for Dentists, Hygienists and Oral Health Industry 2Health News:Rheumatoid Arthritis Hits Women Harder 2
(Date:7/13/2014)... 2014  Eli Lilly and Company (NYSE: ... non-clinical study in genetically engineered mice examining combination ... antibody N3pG and beta-secretase inhibitor BACE (LY2811376). Data ... in removing clumps of amyloid-beta protein in the ... lead to Alzheimer,s disease (AD) – than use ...
(Date:7/11/2014)... -- Rock Creek Pharmaceuticals, Inc. (NASDAQ: RCPI ), ... and Drug Administration ("FDA"), has notified the Company that ... Drug ("IND") application before granting the Company permission to ... Dr. Chris Chapman , RCP,s President, commented, "We ... When we receive the agency,s official comments and/or recommendations, ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
Breaking Medicine Technology:New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 2New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 3Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2
... chronic idiopathic,thrombocytopenic purpura increased and maintained platelet ... with extended treatment, ATLANTA, Dec. 10 ... safety and efficacy of its investigational,drug PROMACTA(TM) ... purpura (ITP).(1) These preliminary results from the,EXTEND ...
... trial specifically designed to evaluate erectile ... function in ED patients with dyslipidemia, ... specifically designed to evaluate erectile function in,erectile dysfunction (ED) ... treating ED, significantly improves the ability,of men with ED ...
Cached Medicine Technology:Long-Term Safety and Efficacy Data on Promacta(TM) (Eltrombopag) Presented at American Society of Hematology Annual Meeting 2Long-Term Safety and Efficacy Data on Promacta(TM) (Eltrombopag) Presented at American Society of Hematology Annual Meeting 3Long-Term Safety and Efficacy Data on Promacta(TM) (Eltrombopag) Presented at American Society of Hematology Annual Meeting 4New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol 2New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol 3New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol 4New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol 5
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: