Study: Delaying evolution of drug resistance in malaria parasit... (ia problems Boni said. Anti-malarial d...)

Study: Delaying evolution of drug resistance in malaria parasite possible

Date:9/4/2008

ia problems," Boni said. "Anti-malarial drug development needs to continue so that we have novel and highly effective anti-malarials that can be plugged into the recommended strategy of deploying multiple therapies."

In the past century, chloroquine and sulfadoxine-pyrimethamine were widely used to combat malaria, but the parasites eventually evolved resistance leading to the drugs' failure. Artemesinin drugs, derived from the herb Artemisia annua, are relatively new and the malaria parasite does not yet appear to have a resistance to it. They work by triggering chemical reactions which damage the Plasmodium parasite.

"We don't have anything in the pipeline after ACTs, and it's basically just a matter of time until drug resistance evolves and artemisinin also fails," Smith said. "So the question becomes how do we keep ACTs in our arsenal for as long as effectively possible?"

The researchers' models also show that cycling through single drugs accelerated the rate at which malaria parasites evolved drug resistance. Smith said this occurred because cycling a single drug degraded the parasite's average fitness, which made it easier for drug-resistant genes to spread throughout the parasite population.

The cycling models predicted a declining therapeutic value of a single drug within 3.54 years, versus a longer effective therapeutic value of 9.95 years when three drugs were used in equal proportions within a population. The research was funded in part by grants from the Bill and Melinda Gates Foundation, and the National Institutes of Health.

"Using multiple first-line drugs reduces the selection pressure for resistance to a single drug," Smith said. "This is one way to make the ACTs last longer and benefit more people."

Co-author Laxminarayan, a senior research fellow at RFF, said ACTs are the best treatment option for malaria, now as well as in the foreseeable future.

"Novel treatment strategies impro
'/>"/>

Contact: DeLene Beeland
tdb@epi.ufl.edu
352-870-6856
University of Florida
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. U. of Chicago study: More than 10 percent of older Americans suffer mistreatment
2. UNC study: chilling hardship rates among families raising disabled children
3. UNC study: Two-thirds of severe sports injuries to female students due to cheerleading
4. UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies
5. Study: verbal aggression may affect childrens behavior
6. UNC study: Common vaginal infection may increase risk of HIV infection
7. Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes
8. UNC study: Out-of-pocket health care costs for disabled children vary widely by state
9. Study: Global Business Performance Significantly Improved Through Project Management
10. Geisinger study: PTSD causes early death from heart disease
11. Study: 9/11 Dogs Suffered Few Health Effects

Post Your Comments:

(Date:5/21/2013)... May 21, 2013 Joe Vitale, a positive ... early adapter of the Fisker electric car. After a year ... since the car company went bankrupt, the bestselling author turned ... , "It's a gas guzzler's anthem," says Vitale, 59, ... album, "Sun Will Rise." , Owning this Fisker was ...

(Date:5/21/2013)... 21, 2013 Limited mobility affects ... Not only is it more difficult to walk around, but ... Fortunately, there are a variety of medical products made to ... product is the raised toilet seat. , Raised toilet ... easier to stand back up or sit down. They come ...

(Date:5/20/2013)... 2013 This week has been dedicated as ... (May 19th-May 25th) is an awareness campaign designated to help ... encouraging dog owners to properly train their pets, and educate ... dog bite lawyers at Buckfire & Buckfire, P.C. represent ... Michigan. The personal injury law firm is a large advocate ...

(Date:5/20/2013)... 2013 Recent environmental concerns have ... green and sustainable inputs in packaging products. As ... to promote the use of sustainable materials, thereby ... Services industry . “Tax subsidies and operating cost ... industry analyst Deonta Smith. “For example, many packaging ...

(Date:5/20/2013)... Daily Gossip, online magazine about lifestyle, health and sports issues, ... can help them overcome one of the most spread skin ... Vitiligo Treatment System has created a buzz on the ... from the persons who have tried it. Its principles have ... some of the people who tried it and managed to ...

Breaking Medicine News(10 mins):Health News:Upset Fisker Owner Records Gas Guzzler Anthem 2 Health News:JustHomeMedical.com Launches Raised Toilet Seats Category 2 Health News:Buckfire & Buckfire, P.C. Dog Bite Lawyers in Michigan Discuss National Dog Bite Prevention Week 2 Health News:Packaging and Labelling Services in Canada Industry Market Research Report Now Available from IBISWorld 2 Health News:Packaging and Labelling Services in Canada Industry Market Research Report Now Available from IBISWorld 3 Health News:New Natural Vitiligo Treatment System That Helps People Treat Vitiligo Permanently Revealed by Daily Gossip Magazine 2

[0] Upset Fisker Owner Records Gas Guzzler Anthem [0] JustHomeMedical.com Launches Raised Toilet Seats Category [0] Buckfire & Buckfire, P.C. Dog Bite Lawyers in Michigan Discuss National Dog Bite Prevention Week [0] Packaging and Labelling Services in Canada Industry Market Research Report Now Available from IBISWorld [0] New Natural Vitiligo Treatment System That Helps People Treat Vitiligo Permanently Revealed by Daily Gossip Magazine

... ... launches SafeConsole 4.0, the web management software for SafeStick, the secure USB flash drive. ... administrators through a series of new features and range of licensing options. , ... Washington, DC (PRWEB) December ...

... , , ... a new market research report is available in ... Industry in the U.S. and its International Trade ... , The newly published In-Vitro Diagnostic Substance Manufacturing ...

... , , , ... a new market research report is available in ... Autoimmune Diseases Therapeutics - Market Forecasts to 2015, ... , http://www.reportlinker.com/p0168100/The-Future-of-Autoimmune-Diseases-Therapeutics---Market-Forecasts-to-2015-Competitive-Benchmarking-Product-Pipeline-and-Deals-Analysis.html , Summary ...

... , SANTA CLARA, Calif., Dec. 15 ... into Santa Clara County for the first time since ... Administrators will be assuming responsibilities and provider contracts previously ... , Operating on a locally based healthcare philosophy, Coastal ...

... is widely thought to be the major form of the ... Research Program (MHRP) researchers, however, have demonstrated that essentially all ... of red blood cells isolated from each of 30 normal ... PLoS ONE , and can be accessed here. ...

... 2009Do good-looking people really benefit from their looks, and in ... Georgia and the University of Kansas found that yes; attractive ... an increased sense of psychological well-being. This seems like common ... each year trying to become more attractive. However, the study, ...

BlockMaster Launches SafeConsole 4.0 To Enhance Usability and Security of USB Devices Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition]Reportlinker Adds The Future of Autoimmune Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis Coastal Healthcare Administrators Expands Provider Network to Santa Clara County New insight into selective binding properties of infectious HIV The importance of attractiveness depends on where you live

(Date:5/20/2013)... , May 20, 2013 National Community Pharmacists ... , RPh, MBA issued the following statement today ... regarding Medicare Part D "preferred pharmacy" drug plans ... patients the plan,s lowest advertised co-payments: (Logo: ... Medicare and MedPAC , 16 U.S. ...

(Date:5/20/2013)... , May 20, 2013 Hill-Rom Holdings, Inc. (NYSE: ... a management presentation at the 38 th Annual ... on May 30, 2013, at 1:30 p.m. ... You are invited to listen to the live ... or access it directly at http://www.media-server.com/m/p/f7bj3q84 . A ...

(Date:5/20/2013)... , May 20, 2013 Sequent Medical, Inc. ... the SL ("Single Layer") family of WEB ® ... of these new models in select neurovascular centers in ... superior navigability that will enable physicians to treat a ... The SL configurations are made possible by further ...

Breaking Medicine Technology:Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 2 Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 3 Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans 4 Sequent Medical, Inc. Launches New SL Family of WEB Aneurysm Embolization Devices 2

[0] Poll: Over One Million Seniors Have Problems with Medicare 'Preferred Pharmacy' Drug Plans [0] Hill-Rom to Participate in the 38th Annual Deutsche Bank Health Care Conference [0] Sequent Medical, Inc. Launches New SL Family of WEB Aneurysm Embolization Devices

... Computerized tomographic (CT),colonography, also known as virtual colonoscopy, ... flexible tube with a camera to view the,lining ... detect cancer and,precancerous polyps and could serve as ... the results of the American College of,Radiology Imaging ...

... Department of,Justice announced today that it will not ... (CRC) to develop and publicize model contract language,for ... Department said,the language is not likely to be ... in contract negotiations, potentially reducing costs,and shortening the ...

Cached Medicine Technology:Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy 2 Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy 3 Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy 4 Justice Department Will Not Oppose CEO Roundtable on Cancer's Proposal 2

Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy Justice Department Will Not Oppose CEO Roundtable on Cancer's Proposal

... Extremely accurate detections of ... well as glaucoma in ... be performed. Smooth operation ... perimetry. High accuracy of ...

... FDT is a breakthrough in visual field testing ... in pre-test. Introducing FDT, the first visual field ... enough to be used even in pre-test. Affordably ... trials behind it to validate performance. The instrument ...

... Matrix represents the latest breakthrough in ... technology, the Humphrey Matrix will help ... evaluation and assess treatment alternatives. Enhanced ... provide complete long-term glaucoma care for ...

... Exceptional comfort for those with ... Toric soft contact lenses let you enjoy ... other soft toric lensa difference youll especially ... throughout the day., This exceptional level of ...

Medicine Products:

Perimeter Humphrey FDT Perimeter Humphrey Matrix Proclear® Toric