Navigation Links
Study: Clot removal devices successful tools for acute ischemic stroke treatment
Date:8/26/2012

Every 40 seconds, someone in the United States has a stroke, usually caused when a clot blocks an artery that supplies blood to the brain. Now the results of two multicenter studies published online in The Lancet on August 26 are giving physicians new innovative tools proven to better remove these clots that block blood flow.

The TREVO 2 clinical trial, (Thrombectomy Revascularization of Large Vessel Occlusions in Acute Ischemic Stroke) showed that the Trevo Retriever, a clot-removal device, performed significantly better at restoring blood supply to the brain than the FDA approved predecessor Merci Retriever. The study, conducted at 16 U.S. sites and one in Spain, was led by neurointerventionalist Raul Nogueira, MD, professor of neurology at Emory University School of Medicine.

Nogueira also served as a member of the steering committee for the SWIFT (Solitaire With the Intention For Thrombectomy) clinical trial, which tested the efficacy of the flow restoration device Solitaire compared to the Merci Retriever at 18 U.S. sites and one in France.

"The results of our studies show these next-generation devices (e.g. stent-retrievers) are superior at achieving restoration of blood flow to blocked arteries and were associated with better neurological outcomes as compared to the previously available technology," says Nogueira, who serves as director of the Neuroendovascular Division at the Marcus Stroke & Neuroscience Center at Grady Memorial Hospital.

"These devices truly refine treatment and represent another great stride in the evolution of stroke care. I'm excited about their potential and the opportunity to offer this cutting edge treatment option to patients at Grady and Emory."

Nogueira enrolled patients at the Marcus Stroke & Neuroscience Center at Grady Memorial Hospital in Atlanta. Located in the region known as the nation's stroke belt, Grady recruited the TREVO 2 study's largest number of patients, enrolling 31 participants. Rishi Gupta, MD, Emory associate professor of neurology, served as the primary investigator at Grady.

Nationwide, researchers randomly assigned 88 patients to the Trevo Retriever group. The remaining 90 patients received the procedure with the Merci Retriever, a predecessor to the Trevo Retriever. Patients treated with the Trevo Retriever scored better on the National Institutes of Health Stroke Scale, experienced shorter hospital stays and had significantly higher rates of functional independence 90 days post-stroke.

In the double-blind, randomized SWIFT trial researchers compared the performance of the Solitaire flow restoration device to the MERCI retriever in a total of 112 patients. Researchers found the blood clot was removed much more commonly with the Solitaire - a self-expanding stent retriever as compared to the Merci retriever. Additionally, more patients had a favorable neurological response with Solitaire than Merci.

The standard of treatment for acute ischemic stroke is an intravenous injection of the clot buster drug tissue plasminogen activator tPA which dissolves the blood clot. However, Nogueira notes limitations such as a short treatment window, risk of bleeding, and failure to dissolve the larger blood clots that often cause the more disabling strokes.

"In this patient population, rapidly restoring blood flow to the brain is critical. Patients who have had large vessel blockage strokes but are ineligible for or fail to respond to intravenous t-PA should be treated with the Trevo or Solitaire device," says Nogueira.

"We have traditionally seen poor outcomes for patients with large vessel occlusion strokes. This new generation of mechanical thrombectomy devices provides us with a highly effective tool for revascularising large vessel strokes and improving overall quality of care in patients with severe and potentially debilitating strokes if they can get to a comprehensive stroke center quickly for treatment."

The Trevo System was developed by Concentric Medical, Inc. and acquired by Stryker. Covidien is the manufacturer of Solitaire. Both devices are now approved in the U.S. and Europe.


'/>"/>

Contact: Juliette Merchant
jmmerch@emory.edu
404-778-1503
Emory University
Source:Eurekalert

Related medicine news :

1. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
2. Study: Insomnia takes toll on tinnitus patients
3. Study: No link between depression, nasal obstruction
4. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
5. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
6. OHSU study: Misdiagnosis of MS is costing health system millions per year
7. UW study: Sleep apnea associated with higher mortality from cancer
8. Study: Heart damage after chemo linked to stress in cardiac cells
9. STeleR study: Telerehab improves functioning after stroke
10. Study: Willingness to be screened for dementia varies by age but not by sex, race or income
11. Study: 21 percent of newly admitted nursing home residents sustain a fall during their stay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
Breaking Medicine Technology: