Navigation Links
Study: Blood transfusion associated with increased risk of death for patients with heart attack

CHICAGO A meta-analysis of 10 studies suggests that receipt of a blood transfusion among patients with myocardial infarction (heart attack) was associated with increased all-cause mortality compared with not receiving a blood transfusion during heart attack, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

Therapeutic measures including anticoagulation and antiplatelet drugs have "revolutionized" the approach to acute coronary syndrome and improved clinical outcomes. However, some of these therapies may also increase the risk for bleeding, which can lead to patients developing anemia during their hospital stay and requiring blood transfusion, according to the study background.

Saurav Chatterjee, M.D., of Brown University and Providence Veterans Affairs Medical Center, Rhode Island, and colleagues conducted a review of studies published between January 1966 and March 2012. Ten studies, including 203,665 participants, were selected for analysis. Only one study was a randomized trial, while the others were observational studies.

"Analyses of blood transfusion in myocardial infarction revealed increased all-cause mortality associated with a strategy of blood transfusion vs. no blood transfusion during myocardial infarction (18.2 percent vs. 10.2 percent), with a weighted absolute risk increase of 12 percent," the authors comment.

Other statistical analyses suggest that blood transfusion was associated with a higher risk for mortality independent of baseline hemoglobin level, nadir hemoglobin level and change in hemoglobin level during the hospital stay. Blood transfusion also appeared to be associated with a higher risk for subsequent myocardial infarction (risk ratio, 2.04), according to the study results.

"In conclusion, this meta-analysis provides evidence that rates of all-cause mortality and subsequent myocardial infarction are significantly higher in patients with acute myocardial infarction receiving blood transfusion. Additional outcomes data are needed from randomized clinical trials that investigate important outcomes with adequate sample size and with low risk for bias," the authors conclude. (Arch Intern Med. Published online December 24, 2012. doi:10.1001/2013.jamainternmed.1001. Available pre-embargo to the media at

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Blood Transfusions, Death and Heart Attack

In a related commentary, Jeffrey L. Carson, M.D., of the University of Medicine and Dentistry of New Jersey, New Brunswick, and Paul C. Hbert, M.D., of the Ottawa Hospital Research Institute, Canada, write: "Do blood transfusions kill more patients with an acute myocardial infarction than anemia? Chatterjee and colleagues would have you believe that they do. We remain unconvinced."

"What might we take away from this systematic review? The authors remind us that patients with an acute myocardial infarction are often anemic and receive red blood cell transfusion. However, because of its many limitations, as physicians, we should not use the results of this review to justify or limit the use of red blood cells," they continue.

"For researchers and decision makers, we can now appreciate how little reliable information is available to inform clinical and policy decisions involving red blood cell transfusions in patients with acute coronary syndrome. Given that real risks and potential benefits exist as to how we choose to use the valuable resource of blood transfusion, we believe that high-quality research is long overdue," they conclude. (Arch Intern Med. Published online December 24, 2012. doi:10.1001/jamainternmed.2013.2855. Available pre-embargo to the media at

Editor's Note: Both authors made conflict of interest disclosures because they have applied for research funding to support a trial to evaluate transfusion thresholds in patients with acute coronary syndrome. One author also disclosed grant support to his institution and his work as a consultant. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Contact: David Orenstein
JAMA and Archives Journals

Related medicine news :

1. Johns Hopkins malpractice study: Surgical never events occur at least 4,000 times per year
2. Study: Curbing car travel could be as effective as cutting calories
3. Study: Treating Sleep Disorder May Thwart Heart Disease
4. Study: Chest CT Scans May Increase Breast Cancer Risk
5. Neuroimaging study: Negative messages less effective on those who are substance dependent
6. University of Tennessee study: Unexpected microbes fighting harmful greenhouse gas
7. Study: Rheumatoid Arthritis Plus Depression May Be Deadly
8. Study: Allergies Need to Be Taken Seriously
9. Diabetes study: Mindful eating equals traditional education in lowering weight and blood sugar
10. Study: Education levels in Asian American neighborhoods affect residents health
11. Study: Metformin offers cardio benefits over sulfonylureas in diabetes
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... As part ... For Empowerment ™ attracts volunteers together who want to combine talents and resources ... key stakeholders in the process. The non-profit launched its first major fundraiser on ...
(Date:11/25/2015)... ... 25, 2015 , ... Finnleo, a leader in the traditional and far-infrared sauna ... and far-infrared saunas. , For traditional saunas, Finnleo is offering 20% ... wood, and Finnleo uses only European Grade A Nordic White Spruce from sustainably grown ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... sauna parts and accessories. , Sauna accessories help improve the bather experience in ... personality. From basic styles for the purist looking for simplicity in design to ...
(Date:11/25/2015)... ... 26, 2015 , ... Ministers, senior government and UN agencies, ... Centres of Excellence, and public R&D institutions, civil societies and other partners gathered ... 5th African Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- ...
(Date:11/25/2015)... ... 2015 , ... For the first time, Vitalalert is donating half of its ... The partnership between the two groups began in 2014 with Vitalalert pledging a portion ... International was founded in 1954 and is an international Christian-based health organization whose mission ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
Breaking Medicine Technology: