Navigation Links
Studies suggest new key to 'switching off' hypertension
Date:7/22/2013

A team of University of California, San Diego researchers has designed new compounds that mimic those naturally used by the body to regulate blood pressure. The most promising of them may literally be the key to controlling hypertension, switching off the signaling pathways that lead to the deadly condition.

Published online this month in Bioorganic & Medicinal Chemistry, the scientists studied the properties of the peptide called catestatin that binds nicotinic acetylcholine receptors found in the nervous system, and developed a pharmacophore model of its active centers. They next screened a library of compounds for molecules that might match this 3D "fingerprint". The scientists then took their in-silico findings and applied them to lab experiments, uncovering compounds that successfully lowered hypertension.

"This approach demonstrates the effectiveness of rational design of novel drug candidates," said lead author Igor F. Tsigelny, a research scientist with the university's San Diego Supercomputer Center (SDSC), as well as the UC San Diego Moores Cancer Center and the Department of Neurosciences.

"Our results suggest that analogs can be designed to match the action of catestatin, which the body uses to regulate blood pressure," said Daniel T. O'Connor, a professor at the UC San Diego School of Medicine and senior author of the study. "Those designer analogs could ultimately be used for treatment of hypertension or autonomic dysfunction."

The research may lead to a new class of treatments for hypertension, a disease which affects about 76 million people, or about one in three adults, in the United States, according to the American Heart Association. Untreated, it damages the blood vessels and is a leading risk factor for kidney failure, heart attack, and stroke.

Despite being a common and lethal cardiovascular risk factor, hypertension remains only partially controlled by current antihypertensive medication
'/>"/>

Contact: Cassie Ferguson
casferguson@gmail.com
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Health Affairs July issue contains global innovation studies from India And Brazil
2. Dr. Sam Speron Agrees With New Studies Explaining The Difference In Skin Aging Between Men and Women
3. Neurosurgery publishes findings of 3 important studies in June issue
4. The Lap Band Surgery Center: Review of Lap Band Surgery Issues From Recent Studies
5. Genetic studies lead to clinical trial of new treatment for type 1 diabetes
6. Medical Doctor Studies, Inc Announces Open House Meetings
7. Palomar Modular Buildings Releases Education Project Case Studies
8. Biomet Hip Replacement Lawsuits: Bernstein Liebhard LLP Comments on Ongoing Biomet M2a Magnum Hip Replacement Studies
9. MGH-led studies shed new light on targeted lung cancer therapy
10. Studies Shows “Fat Talkers” Are Less Liked by Peers
11. Zane Benefits Publishes New HRA Case Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... May 03, 2015 NuevaCare announced today ... two upcoming area seminars. The first event will take ... Regional Stroke Conference to be held at The Magnolia ... Wednesday, May 13 during the Dementia Conference to be ... “These seminars offer an excellent opportunity to learn about ...
(Date:5/2/2015)... As one of only 30 Illinois companies to be ... and Recognition Program (SHARP) certification, Essentra Specialty Tapes ... Department of Labor to host this special event. ... the Occupational Safety and Health Administration’s (“OSHA”) Onsite Consultation ... or exceed all of the necessary regulations and standards, ...
(Date:5/2/2015)... Aliso Viejo, CA (PRWEB) May 02, 2015 ... made exclusively for use in Final Cut Pro X. ... ready for use in Final Cut Pro X . ... a single keyframe with Pixel Film Studios' ProText Kinetic 2. ... drop. Start by staggering two ProText Kinetic presets in ...
(Date:5/2/2015)... On Tuesday April 7th, the patient ... to celebrate improvements in patient care. In 2014 the ... had zero acquired ventilator associated infections, zero central line ... was also recently named a Top Performer by the ... credited the teamwork of staff from all departments involved ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 With the success ... company is proud to welcome Neida Miranda and Alex Shields ... Dental Consulting has over 41 years of combined experience working ... been in the dental field for 8 years. She ... in Waco, Texas. Customer service, positive attitude and showing the ...
Breaking Medicine News(10 mins):Health News:NuevaCare Introduces MnemeTherapy® Approach to Care for Elderly Patients with Alzheimer’s, Stroke and Other Types of Neurodegenerative Conditions 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:Veatch Dental Consulting Services Welcomes New Team Members 2
... Care Foundation will identify ways to expand access to ... Foundation today announced it has awarded a $200,000 12-month ... Care Foundation (Partners) with the goal of expanding access ... in the Santa Clarita Valley and South Los Angeles. ...
... DIEGO, Jan. 27 Cardium Therapeutics (NYSE Alternext ... today announced the launch of InnerCool,s newly redesigned ... and expanded website highlights InnerCool,s new RapidBlue(TM) high-performance ... and CoolConnect Adapters to allow CoolBlue surface pads ...
... Nova Scotia, Jan. 27 Medusa Medical Technologies ... patient care reporting software, the Siren ePCR Suite(TM) ... Philips HeartStart MRx monitor/defibrillator. This integrated solution ... for patient care and reporting in the pre-hospital ...
... Jan. 27 Midwest Sports Events announced,today that Anthem Blue ... sponsor for three race events in northeastern Wisconsin ... bicycle event in Fond du Lac,and Green Bay Duathlon at ... As the title sponsor, Anthem Blue Cross ...
... tool in the fight against,oral cancer is now being offered ... at http://www.barotzdental.com , determines a,person,s risk for oral cancer ... "About 34,000 Americans are diagnosed with oral cancer each year. ... exceptionally high death rate,because it is routinely discovered late in ...
... Inc. (OTC Bulletin Board: EMED) a leading provider of ... healthcare industry, which recently signed letters of intent to ... a leading provider of HIPAA compliant medical, dental, healthcare ... industry is pleased to announce that it has appointed ...
Cached Medicine News:Health News:The SCAN Foundation Funds New Program for Santa Clarita and South Los Angeles Seniors and Those Who Care for Them 2Health News:The SCAN Foundation Funds New Program for Santa Clarita and South Los Angeles Seniors and Those Who Care for Them 3Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 2Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 3Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 4Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 5Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 6Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 7Health News:Cardium's InnerCool Announces Launch of New Enhanced Website 8Health News:Medusa Medical Technologies Announces Integration of Siren ePCR Suite(TM) with Philips HeartStart MRx Monitor/Defibrillator 2Health News:Medusa Medical Technologies Announces Integration of Siren ePCR Suite(TM) with Philips HeartStart MRx Monitor/Defibrillator 3Health News:Anthem Blue Cross and Blue Shield to Serve as Title Sponsor for Three Race Events in Northeastern Wisconsin 2Health News:Anthem Blue Cross and Blue Shield to Serve as Title Sponsor for Three Race Events in Northeastern Wisconsin 3Health News:Barotz Dental Offers Free Online Oral Cancer Risk Assessment 2Health News:MedCom USA, Inc. Announces Appointment of One New Board Member and Removal of Two Existing Board Members 2Health News:MedCom USA, Inc. Announces Appointment of One New Board Member and Removal of Two Existing Board Members 3
(Date:5/1/2015)... Pharmacyclics, Inc. (the "Company") (NASDAQ: PCYC ) today ... 2015, as well as general business updates. Due to ... be held. Key Highlights , Total ... to $206 million from $119 million for the quarter ... (ibrutinib) net product revenue of $247 million was ...
(Date:5/1/2015)... 1, 2015  Misonix, Inc. (NASDAQ: MSON ... manufactures and markets innovative therapeutic ultrasonic products for ... surgery, laparoscopic surgery and other surgical applications, announced ... the third quarter fiscal year 2015 on Thursday, ... conference call that same day, Thursday, May 7, ...
(Date:5/1/2015)... -- Shares of Aerie Pharmaceuticals, Inc. (NASDAQ: AERI ) ... results of the Phase 3 Rocket 1 trail of ... to meet its end points, compelling data from the ... studies. An analyst report on AERI that ... analyst summary, valuation, and recommendation can be viewed by ...
Breaking Medicine Technology:Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 2Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 3Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 5Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 6Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 7Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 8Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 9Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 10Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 11Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 12Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 13Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 14Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 15Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 16Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 17Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 18Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 19Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 20Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 21Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 22Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 23Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 24Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 25Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 26Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 27Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 28Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 29Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 30Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 31Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 32Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 33Misonix, Inc. To Report Third Quarter Fiscal Year 2015 Financial Results On Thursday, May 7, 2015 2All is Not Lost for Aerie Pharmaceuticals - VLM Research Issued by BrokerBank Securities, Inc. 2
Ideal for use with low volume samples on the Biomek robotic pipetting systems, the ART 20R provides guaranteed protection for your expensive workstation....
... false signals and contamination caused by ... Barrier Tips offer performance and economy ... (PCR(a)), radioactive isotopes, tissue culture fluids, ... , ,Promega Barrier Tips are made ...
... Eppendorf Barrier Tips. Designed to fit Eppendorf Pipettors. ... of DNA and proteins bound to the tip. ... retention, which means the focus is on liquid ... also focuses on low binding which reduces the ...
10 L, Racked, Pre-sterilized, 96 tips/rack Recommended for 2, 5 and 10 L pipettes....
Medicine Products: