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Studies suggest key correlation between lung cancer subtype and treatment outcomes
Date:9/26/2007

BARCELONA, SPAIN, September 25, 2007 In clinical research, patients with advanced non-small cell lung cancer (NSCLC) that are classified as having a non-squamous histology achieve statistically significant higher survival when treated in the second-line setting with ALIMTA (pemetrexed for injection) when compared to histologically-similar patients treated with docetaxel. The data (ECCO Abstract # 6521) were presented at the 14th European Cancer Conference (ECCO) in Barcelona. ALIMTA, manufactured and marketed by Eli Lilly and Company, is currently indicated for the second-line treatment of advanced NSCLC in more than 85 countries.

The retrospective analysis of Phase III data consisted of 571 patients. The analysis showed that non-squamous patients treated with ALIMTA achieved a statistically higher overall survival compared to those treated with docetaxel (9.3 months and 8.0 months, respectively; hazard ratio 0.778 [95% CI 0.607-0.997]). Conversely, the analysis suggested that patients with a squamous histology and treated with docetaxel had a statistically higher overall survival compared to those treated with ALIMTA (7.4 months and 6.2 months respectively; hazard ratio 1.563 [95% CI 1.079, 2.264]). Patients with a non-squamous histology represented the majority of the patients on the trial.

The retrospective analysis was driven by preclinical data that suggested patients with a lower expression of thymidylate synthase (TS) enzyme show an increased efficacy when treated with ALIMTA. , The histological type of NSCLC is determined by how the cancerous cells appear under a microscope. Two of the most common histological types of NSCLC are adenocarcinoma and large cell carcinoma and constitute approximately 55 percent of all NSCLC diagnoses. These two subgroups, and any other types not identified as squamous, were considered non-squamous for this analysis.

This particular analysis suggests that histology may play an impor
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Contact: Neil Hochman
n.hochman@cprworldwideusa.com
212-453-2067
CPR Worldwide
Source:Eurekalert

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