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Studies show Vectra(TM) DA can track early response to rheumatoid arthritis therapy
Date:5/24/2011

2011, 10:15 BST)

Blood samples from the UK based REMIRA (Remission in RA) study acquired at baseline from 70 RA patients on stable therapy with less than 10 years of disease and DAS28 of less than 3.2 were examined to determine whether Vectra DA could differentiate between low disease activity and remission. Multiple definitions of remission were assessed, including those for standard clinical disease activity scores (DAS28, CDAI, SDAI) and the new American College of Rheumatology (ACR)/EULAR criteria.

A statistically significant (p< 0.01 in all cases) association was observed between the Vectra DA algorithm score and the current clinical standards for evaluating RA remission vs. non-remission.

Overview of Multi-Biomarker Structural Damage Test Data

Development of A Multi-Biomarker Algorithm to Predict RA Structural Damage in the Leiden Early Arthritis Cohort (Poster Session II: May 27, 2011, 11:45 BST)

Researchers evaluated both individual biomarkers and prototype multi-biomarker models to predict the risk and degree of joint damage in an individual patient over 12 months. Biomarker concentrations were determined in 307 blood samples from 187 patients in the Leiden Early Arthritis Cohort, a Dutch population-based cohort.

The study found that biomarker combinations had higher observed performance than conventional clinical measures at predicting progressive structural damage in RA. A multi-biomarker test, if validated, has the potential to better predict structural damage in clinical practice.


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Contact: June Fujimoto
jfujimoto@crescendobio.com
650-351-3065
GCI Health
Source:Eurekalert

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