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Studies show Vectra(TM) DA can track early response to rheumatoid arthritis therapy
Date:5/24/2011

er Heijde Sharp Score, a common radiographic scoring method used to assess joint damage in RA (p< 0.05). The results suggest that the combination of biomarkers in the Vectra DA algorithm reflects the underlying disease processes.

Robustness of a Novel Multi-Biomarker Score for RA Disease Activity (Vectra DA) Across a Spectrum of Co-Morbidities and Smoking Status (Poster Session II: May 27, 2011, 11:45 BST)

This study selected 512 subjects from the InFoRM Study, a geographically diverse North American cohort, and assessed whether comorbid conditions affected disease activity measures. The study found that common comorbid conditions had no significant impact on the Vectra DA algorithm score. In an exploratory analysis of patients with fibromyalgia, the Vectra DA algorithm score had greater observed stability than the other common disease activity measures DAS28, CDAI and CRP.

A Multi-Biomarker Based Disease Activity (MBDA) Score System Compared to a Conventional Disease Activity Score (DAS) System in the BeSt Rheumatoid Arthritis (RA) Study (Poster Session III: May 28, 2011, 10:15 BST)

Blood samples were analyzed from 124 RA patients at 180 visits in the BeSt study. The Vectra DA algorithm score was significantly correlated with three standard clinical disease activity scores (DAS, DAS28 and DAS28CRP; p< 0.001 in all cases). In addition, change in the Vectra DA algorithm score was significantly correlated with change in DAS28 between baseline and 1 year study visits, indicating that the Vectra DA algorithm can track changes in disease activity over time.

Biomarker Signatures in Rheumatoid Arthritis Patients with Low Disease Activity: The REMIRA Study (Poster Session III: May 28,
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Contact: June Fujimoto
jfujimoto@crescendobio.com
650-351-3065
GCI Health
Source:Eurekalert

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