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Studies show Vectra(TM) DA can track early response to rheumatoid arthritis therapy
Date:5/24/2011

ime," said David Chernoff, MD, Chief Medical Officer of Crescendo Bioscience. "These data further validate Vectra DA's broad utility in providing physicians with quantitative information on RA disease activity and underlying biology. Vectra DA provides a tool to help personalize patient management."

Overview of Vectra DA Algorithm Data

Use of a Multi-Biomarker Score for Rheumatoid Arthritis Disease Activity (Vectra DA) to Assess Response to Therapy (Poster Session I: May 26, 2011, 11:45 BST)

Patients from the Brigham and Women's Rheumatoid Arthritis Sequential Study (BRASS) diagnosed with RA received methotrexate (MTX) or anti-TNF therapy with MTX, based on their physician's recommendation. Changes in the Vectra DA algorithm score occurred as early as two weeks after initiating therapy and were significantly associated with subsequent clinical responses (p=0.01).

A Multi-Biomarker Algorithm for RA Disease Activity (Vectra DA) Predicts Radiographic Progression in the BeSt Study (Poster Session I: May 26, 201, 11:45 BST)

Researchers analyzed blood samples from baseline and year one of 124 patients from the Behandel Strategieen (BeSt) clinical study to determine whether, in addition to its validated use to assess and track disease activity, the Vectra DA algorithm could help predict progressive joint damage. Disease activity is a significant risk factor for joint damage.

The Vectra DA algorithm score was significantly associated with joint damage progression, (p< 0.001). In a multivariate regression analysis including other disease activity measurements, only the Vectra DA algorithm score was a significant predictor of the second year change in Van d
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Contact: June Fujimoto
jfujimoto@crescendobio.com
650-351-3065
GCI Health
Source:Eurekalert

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