Navigation Links
Studies shed light on preserving fertility among cancer patients
Date:7/20/2009

PITTSBURGH, July 20 Cancer treatment has come a long way, leading to a multitude of therapy options and improved survival rates. These successes, however, have created a challenge for young cancer patients since chemotherapy and radiation treatments that often save lives threaten fertility. Techniques available to safeguard fertility, such as freezing eggs for later embryo development, have poor odds of success, leaving patients with very limited options for the future. But that is beginning to change as researchers improve current techniques, mature human eggs in the laboratory, and discover cellular mechanisms that could help preserve and even restore fertility. Researchers will report on these and other findings at the 42nd annual meeting of the Society for the Study of Reproduction (SSR), July 18 to 22, at the David L. Lawrence Convention Center in Pittsburgh.

Summaries of the findings are as follows:

Growing Egg Cells in the Lab

Researchers at Northwestern University are developing a method they hope will help preserve a woman's fertility after radiation and chemotherapy treatment. Led by Teresa K. Woodruff, Ph.D., the team has grown undeveloped human eggs to near maturity in laboratory cultures. During a 30-day experiment, they grew human follicles―tiny sacs that contain immature eggs―in the lab until the eggs they contained were nearly mature. According to Dr. Woodruff, this is the first step in developing a new fertility option for young cancer patients.

Making a More Viable Embryo

Cryopreservation, the process of freezing eggs for later fertilization, has played a major role in assisted reproductive technology for the past two decades. Unfortunately, however, eggs rarely survive the freezing and thawing processes required to develop a viable embryo. A mere half of eggs survive and of these, only 20 percent, once fertilized, result in the birth of a baby. According to David Albertini, Ph.D., University of Kansas Medical Center, clinicians may be waiting too long three hours after thawing eggs to initiate fertilization with the sperm, a process necessary to create an embryo. When his research team used confocal microscopy to observe what was happening at a chromosomal level, they found that the structures needed to make the embryo's chromosomes align and divide were in place after only an hour. This indicates a shorter thawing time frame could have greater potential for success.

Restoring Fertility From the Bottom Up

Researchers at Stanford University, led by Renee A. Reijo Pera, Ph.D., have identified several genes involved in the formation of germ cells that give rise to eggs and sperm. These genes, DAZ and DAZL, form the basis of human embryo and germ cell growth and may be a key to understanding human reproductive failure one of the most common health problems in men and women and a common cause of birth defects. While continued progress in developing germ cells capable of making embryos renders fertility restoration feasible, it also raises significant ethical questions, says Dr. Reijo Pera.


'/>"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies
2. CNCB Post Graduate Studies in Clinical Nutrition (PGSCN) Program is Now Available Online
3. 105-Day Mars Simulation: U.S. Studies Focus on Improving Work Performance
4. 105-day Mars simulation: US studies focus on improving work performance
5. Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII
6. Three New Studies Give Clear Guidance on How to Better Recruit Volunteers for Alzheimers Clinical Studies
7. Latest Studies Show Junk Drinks Pose as Many Health Threats as Junk Food According to AquaHydrate Medical Advisor
8. Video: Perot Systems Unveils Series of Healthcare Video Case Studies
9. Center receives grant renewal for hypertension and vascular disease studies
10. Prostate screening studies reviewed in European Urology July issue
11. Statement from IDF on studies suggesting possible link between insulin glargine and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology: