Our finding that adiponectin may have a protective effect on asthma in women may open up doors to new ways of treating asthma, said lead researcher Akshay Sood, M.D., M.P.H., associate professor in the Division of Pulmonary and Critical Care Medicine at the University of New Mexico Health Sciences Center School of Medicine in Albuquerque. The findings have particular relevance for obese women, since they are more likely to have low blood adiponectin concentrations.
While human studies of adiponectin and asthma are still in the early stages, studies of mice indicate that this protein plays a role in airway inflammation and airway hyperreactivity, or twitchiness, both of which are factors in asthma.
Because of the increase in asthma prevalence, as well as obesity, there should be a lot of interest in continuing to study the effect of products of fat cells on asthma, Dr. Sood said.
Adipokine-Asthma association: Does Lung Talk to Adipose Tissue" (Abstract p. A832; Poster #306)
High Protein Levels May Signal Lower Lung Function
A second study based on CARDIA data being presented at 8:15 a.m. finds that higher levels of proteins called ICAM-1 (intracellular adhesion molecule) are associated with lower lung function.
ICAM-1 exists in the cells called endothelial cells that line the arteries, and helps initiate the immune systems inflammatory response to invaders such as cholesterol deposits.
Circulating ICAM-1 is a measure of dysfunction of the endothelial cells, which are the intimal lining of arteries and are in capillaries, said study co-author David Jacobs, Ph.D., Mayo Professor of Public Health at the University of Minnesota in Minneapolis. Weve known that people with lower lung function have more cardiovascular disease and cardiovascular deaths than those with better lung function, and that these two things are somehow related, but t
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American Thoracic Society