At three years, in patients still in first remission, the unadjusted cumulative relapse incidence was significantly less in patients who received a double as compared to a single transplant (15 percent and 25 percent, respectively). The rates of leukemia-free survival were also higher in those receiving a double versus a single transplant (53 percent and 39 percent, respectively). Additionally, the incidence of non-relapse mortality was 32 percent in those receiving a double cord blood transplant compared with 36 percent in those who received a single cord blood transplant. There was a significant difference in acute graft-versus-host disease incidence between the two treatment groups, with 45 percent experiencing the complication after a double transplant compared with 27 percent following a single transplant. For those patients in a second or third complete remission, outcomes following the double transplant were not statistically different from those receiving a single transplant.
"Results from this analysis demonstrate that not only is a double cord blood transplant feasible, but the procedure is associated with better overall outcomes, especially when it is used early in the treatment of acute leukemias," said Vanderson Rocha, MD, PhD, Scientific Director of Eurocord Registry, Hopital Saint Louis, Paris. "Prospective clinical trials are currently underway in Europe and the United States in order to confirm the results seen in this study."
Dr. Rocha will present this study in an oral presentation on Tuesday, December 7, at 7:30 a.m. in Room 109A.
Contact: Lindsey Love
American Society of Hematology
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