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Studies highlight role of stem cell transplant procedures for blood cancer treatment
Date:12/6/2010

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Outcomes After Double Unit Unrelated Cord Blood Transplantation (UCBT) Compared With Single UCBT in Adults With Acute Leukemia in Remission. An Eurocord and ALWP Collaboration Study [Abstract 910]

One of the most significant limitations of cord blood transplantation, a procedure in which stem cells are collected from the umbilical cord and placenta after a baby is born, is that each cord blood unit contains limited volumes of blood, which translates into limited stem cells available for transplantation. The number of stem cells needed for a successful cord blood transplant is largely dependent on the size and weight of the patient. Often times hematopoietic stem cells from one cord blood donor are not sufficient to transplant one adult patient. In order to increase the number of cells, adult patients may need to receive two units of cord blood from two different donors.

Previous research from the University of Minnesota has shown that patients with acute leukemia who receive a double infusion of stem cells through an unrelated cord blood transplant have a lower incidence of relapse and a similar rate of leukemia-free survival, but a higher incidence of acute graft-versus-host disease than patients who receive a single cord blood stem cell transplant.

In order to confirm these findings, an analysis of outcomes from a larger population of patient outcomes was conducted to evaluate the benefits of a double unrelated versus a single unrelated cord blood transplant. Researchers from Eurocord, an international registry that collects and validates data from cord blood transplants, and the Acute Leukemia Working Party (ALWP), one of the specialized working groups of the European Group for Blood and Marrow Transplantation (EBMT), collaborated to retrospectively analyze data. This stu
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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