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Studies highlight role of stem cell transplant procedures for blood cancer treatment
Date:12/6/2010

The progression/relapse rates were 50 percent and 46 percent, and treatment-related mortality was 4 percent and 11 percent for the auto-auto arm and auto-allo arm, respectively. In those patients who received the assigned second transplant (82 percent in each arm), the three-year progression-free survival rate was 47 percent for the auto-auto arm and 44 percent for the auto-allo arm. Results of this study show that, in patients with standard risk multiple myeloma, an autologous stem cell transplant followed by reduced insensity allogeneic transplant did not differ from a tandem autologous stem cell transplant in terms of progression-free or overall survival.

The investigators reported that there was poor overall compliance with the maintenance therapy of thalidomide and dexamethasone in the auto-auto arm, with 84 percent of patients not completing the therapy due to overall poor tolerability of this regimen. Progression-free survival and overall survival between the maintenance and observation groups were not significantly different, perhaps due to the high rate of discontinuation of maintenance therapy.

"Research has shown that allogeneic stem cell transplantation can be a curative procedure for certain groups of patients with multiple myeloma; however, it can be associated with increased morbidity and mortality over autologous transplant. Therefore, it is still unknown if this procedure is better in some patients than in others or if it should be the standard of care for all myeloma patients," said lead study author Amrita Krishnan, MD, Director of the Multiple Myeloma Program at the City of Hope Cancer Center in Duarte, CA. "Our study addresses this unanswered question and shows that the toxicity of allogeneic transplantation outweighed the benefits of the reduced relapse risk in patients with standard-risk myeloma."

Dr. Krishnan will present this study in an oral presentation on Sunday, December 5, at 4:30 p.m. in Room 109A.'/>"/>

Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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