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Studies highlight role of stem cell transplant procedures for blood cancer treatment
Date:12/6/2010

health was very good or good (95.1 percent of PBSC donors, 96 percent of bone marrow donors, and 92.2 percent of dual donors). Furthermore, an overwhelming majority also indicated that they would undergo the donation procedure again, with 95.4 percent of PBSC donors and 95.9 percent of bone marrow donors indicating willingness.

Regarding the incidence of cancer in these donors, a total of 85 malignancies were reported, which included 50 cases in 8,730 PBSC donors, 31 cases in 23,037 bone marrow donors, and four cases in 1,414 dual donors. With regard to hematologic malignancies, only six cases were reported, including two cases of Hodgkin disease and one case of plasmocytoma in PBSC donors, one case of acute myeloid leukemia and one case of non-Hodgkin lymphoma in bone marrow donors, and one case of chronic lymphocytic leukemia in dual donors.

"Results of this study provide the best evidence we have so far that there is not a higher incidence of cancer associated with the donation of unrelated peripheral blood stem cells and bone marrow as compared with the general population," said lead study author Alexander H. Schmidt, MD, PhD, DKMS German Bone Marrow Donor Center. "We hope that these results underscore the fact that these donation procedures are extremely safe and will encourage more people to become donors."

Dr. Schmidt will present this study in an oral presentation on Monday, December 6, at 10:30 a.m. in Room 110B.

Tandem Autologous Hematopoietic Stem Cell Transplants (AuHCT) With or Without Maintenance Therapy (auto-auto) Versus Single AuHCT Followed by HLA Matched Sibling Non-Myeloablative Allogeneic HCT (auto-allo) for Patients With Standard Risk (SR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 Trial [Abstra
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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