Navigation Links
Studies examine treatment for gout and the condition's protective effects
Date:11/4/2008

The goal in treating patients with gout is to reduce acute attacks by lowering serum urate levels, which are usually high in this disease. At the same time, high serum urate levels have been shown to lower the risk of developing Parkinson's disease (PD). A new study compared the safety and efficacy of febuxostat, a new drug being developed for gout that was recently approved for use in Europe, and a commonly used drug that has been around for years. Another study examined the link between gout and PD in individuals 65 years and older. The studies were published in the November issue of Arthritis Care & Research (http://www3.interscience.wiley.com/journal/77005015/home).

For many years, the most common drug used to treat gout was allopurinol, which is generally safe and effective, but has been known to cause life-threatening rashes in rare cases. Its dosage often has to be reduced in patients with impaired kidney function, but previous clinical trials have shown that febuxostat is effective at lowering urate levels and that its dosage may not need to be adjusted.

A Phase III, randomized, double-blind multi-center trial, known as the APEX (Allopurinol- and Placebo-Controlled, Efficacy Study of Febuxostat) trial, was conducted to compare the safety and efficacy of febuxostat with allopurinal and a placebo in patients with high urate levels (uricemia) and gout, some of whom had impaired renal function. It was the largest randomized controlled clinical trial to date comparing the two drugs. Led by H. Ralph Schumacher of the University of Pennsylvania, the 28-week trial involved 1,072 patients at 167 sites in the U.S. who had serum urate levels of at least 8 mg/dl and gout, with normal or impaired renal function. Patients were randomized to receive one of three dosage levels of febuxostat once daily; allopurinol; or a placebo. The allopurinol dose given was based on kidney
'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Gene Studies of Male-Female Differences Often Flawed
2. Two studies published in the Lancet
3. Study of Studies Finds No Risk to Children From Phthalates in Toys
4. Just Completed Studies Reveal Impact of New Medicare Reimbursement Regulations
5. Studies Prove Exercise Can Heal the Body Mind and Soul
6. Studies Shed New Light on Breast Cancer, Treatment
7. Multi-Year Compendium of Pharmaceutical Case Studies Available from Best Practices, LLC
8. Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium
9. Best Practice Database: Complimentary Excerpt of Three Sales Force Excellence Studies
10. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
11. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... United Arab Emirates (PRWEB) July 12, 2014 ... another Los Angeles basketball legend is heading to the ... scorer and six-time champion will be in the UAE ... & Fitness Weekend in support of diabetes awareness. The ... an award-winning entertainment marketing and event management company based ...
(Date:7/12/2014)... Los Angeles, CA (PRWEB) July 12, 2014 ... a buyer power score of 4.1 out of ... the market that have been underpinning buyer negotiation ... to IBISWorld procurement analyst Anna Son, “during the ... along with rising costs associated with new product ...
(Date:7/11/2014)... (PRWEB) July 12, 2014 Recently, DressyQuinceanera.com, ... 200 Quinceanera Dama dresses to its online ... items are offered at deeply discounted rates, up to ... from DressyQuinceanera.com are equally excellent in terms of quality ... carefully handmade. Similar discounts are also offered for the ...
(Date:7/11/2014)... Lewisberry, PA (PRWEB) July 11, 2014 Butler ... line of Inclined Platform Lifts . Previously the ... now offering five new beautiful earth tone colors as standard ... only blend well in the home but will enhance the ... color choice for any home color scheme or individual décor. ...
(Date:7/11/2014)... July 11, 2014 Microbiology testing is ... in-vitro diagnostics industry, which is expected to pose the ... The sector owes its growth to the ongoing spread ... health worldwide and a major factor leading to the ... of bio-terrorism, and a broader availability of immunosuppressants, among ...
Breaking Medicine News(10 mins):Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3
... 113 children and teens physically victimized by peers concludes ... and diffuse threats makes them far less likely to ... immediate aftermath of the attack. , The research, by ... Medical Center in Washington, D.C., was conducted on 10- ...
... The International Diabetes,Federation (IDF) announced today that Ms ... Officer/Executive Director., The International Diabetes Federation, headquartered ... 200 diabetes associations,worldwide. It is the global advocate ... their families, and healthcare providers., Ms Keeling ...
... home safety review could cut odds of fractures in those ... Former first lady Nancy Reagan and Democratic presidential candidate ... And on Friday, author Studs Terkel died, following reports that ... Such news, experts say, should be a reminder to all ...
... study shows that an imaging technology developed by Mayo ... and help eliminate the need for liver biopsies. ... to incurable cirrhosis if not treated in time. , ... images known as elastograms that indicate how internal organs, ...
... health care coverage, yet oppose a government mandate to do so, a ... candidates’ health care proposals. , ... New York, NY (PRWEB) November 1, ... health care coverage, yet oppose a government mandate to do ...
... study in the Nov. 1 issue of the journal ... specific neurochemical abnormality in adults with primary insomnia, providing ... pathology. , Results indicate that gamma-aminobutyric acid (GABA), ... reduced by nearly 30 percent in individuals who have ...
Cached Medicine News:Health News:Memo to ER docs: Send young victims of violence for 1-on-1 counseling 2Health News:Memo to ER docs: Send young victims of violence for 1-on-1 counseling 3Health News:New Chief Executive Officer Joins International Diabetes Federation 2Health News:Falls Are Leading Cause of Injury to Seniors 2Health News:Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease 2Health News:Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches 2Health News:Employers “Vote” on Presidential Candidates' Health Care Platforms: Prefer Middle Ground Between the Two Approaches 3Health News:Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults 2Health News:Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults 3
(Date:7/10/2014)... NEWS, Virginia , 11. Juli ... Hersteller von Kameras für die molekulare ... (MBI/BSGI), hat heute die CE-Zulassung für ... dem CE-Zeichen kann Dilon das Produkt ... Vertriebsbereich auf den Großteil der europäischen ...
(Date:7/10/2014)...  RESMED INC. (NYSE: RMD ) today announced ... ended June 30, 2014 results on Thursday, July 31, 2014, ... release with ResMed,s results will be issued after 1:00 p.m. ... to discuss operating results and future outlook. The ... Pacific Time and the live webcast of the call can ...
(Date:7/10/2014)... 2014   Ventana Medical Systems, Inc.  (Ventana), a ... entered into an agreement with Merck KGaA, Darmstadt, ... in the United States and ... KGaA,s biopharmaceutical division on the development and commercialization of ... Ventana,s proprietary diagnostic assays. In alignment with Merck KGaA,s ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... , NEW YORK, Dec. 2 ... available in its catalogue: , Pharmaceutical Contract ... http://www.reportlinker.com/p0164248/Pharmaceutical-Contract-Manufacturing---Global-Market-Trends.html , Global pharma industry ... in generic markets, rising cost of new product development, ...
... , JUPITER, Fla., Dec. 2 Jupiter Medical ... diagnostic tools available into its imaging program, the new Signa ... highly detailed images of the human body with increased speed, ... non-contrast vascular imaging for patients with renal dysfunction. This ...
Cached Medicine Technology:Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 2Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 3Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 4Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 5Jupiter Medical Center Announces New High-Definition MRI System 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: