Navigation Links
Studies elucidate genetic links between cancer and schizophrenia
Date:12/8/2007

Boca Raton, FL, December 8, 2007 A series of studies presented today at the American College of Neuropsychopharmacology (ACNP) annual meeting elucidates evidence that there is a genetic link between schizophrenia and cancer, providing a surprising possible scientific explanation for lower rates of cancer among patients with schizophrenia despite having poor diets and high rates of smoking and their parents.

Researchers at the National Institute for Mental Health (NIMH) emphasize that many of the genes associated with schizophrenia are the same as the genes associated with cancer, but that the cells that have these genes use them in opposite ways in the two disorders. While cancer results from changes in the genes that cause cells to go into metabolic overdrive and multiply rapidly, those same genes cause cells in schizophrenia to slow to a crawl.

We found that many of the same genes are involved in schizophrenia as in cancer, but in a yin and yang way. This will provide critical insight into the molecular structure of schizophrenia, said lead researcher and ACNP member Dr. Daniel Weinberger of NIMH. Some of the genes showing this yin-yang effect include NRG1, AKT1, PIK3, COMT, PRODH and ErbB4. While these genes cant be used to predict exactly who will develop these diseases, Dr. Weinberger says they can be used to help determine risk.

Dr. Amanda Law of the University of Oxford, who heads one of the teams working at the NIMH, explored specific genetic pathways that cells use to make basic decisions about their development and their fate.

This is about basic decision making by cellswhether to multiply, move or change their basic architecture, says Dr. Law. Cancer and schizophrenia may be strange bedfellows that have similarities at the molecular level. The differences lie in how cells respond to external stimuli: in cancer the molecular system functions to speed up the cell and in schizophrenia the system is altered in such a way that causes the cell to slow down. Law adds that selective targeting of these pathways may be a potential target in developing treatments for schizophrenia.

Its very curious that a brain disorder associated with very complicated human behavior has at a genetic and cellular level a striking overlap with cancer, a very non-behavior related disorder. Understanding these pathways might provide us with some new strategies for thinking about cancer, said Dr. Weinberger.

Dr. Weinberger added that future research involves using this information to search for therapeutic insights that can reverse these processes, with implications not only for treatment of schizophrenia, but also maybe for cancer as well.

An estimated two million Americans have schizophrenia, a biological condition that affects a persons ability to think clearly, distinguish reality from fantasy, to manage emotions, make decisions and relate to others. The World Health Organization has identified schizophrenia as one of the ten most debilitating diseases affecting humans.


'/>"/>

Contact: Sharon Reis
sreis@gymr.com
202-745-5103
American College of Neuropsychopharmacology
Source:Eurekalert

Related medicine news :

1. Gene Studies of Male-Female Differences Often Flawed
2. Two studies published in the Lancet
3. Study of Studies Finds No Risk to Children From Phthalates in Toys
4. Best Practice Database: Complimentary Excerpt of Three Sales Force Excellence Studies
5. Just Completed Studies Reveal Impact of New Medicare Reimbursement Regulations
6. Studies Prove Exercise Can Heal the Body Mind and Soul
7. Studies Shed New Light on Breast Cancer, Treatment
8. Multi-Year Compendium of Pharmaceutical Case Studies Available from Best Practices, LLC
9. Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium
10. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
11. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... ... ATA 2017 President’s Awards recipients, comprised of organizations and individuals who have ... , The ATA 2017 President’s Awards recognize individuals and organizations on the ...
(Date:4/26/2017)... ... 26, 2017 , ... Elisabete Miranda, president and CEO of ... Women magazine as one of its 2017 Enterprising Women of the Year, a ... demonstrated that they have fast-growth businesses, mentor or actively support other women and ...
(Date:4/26/2017)... , ... April 26, 2017 , ... Miami native and ... a dentist. , “I could have never imagined back in 1991 that this journey ... Dr. Gallardo. , Over the last 25 years, Dr. Gallardo has pioneered implant dentistry ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... improve the profitability of ready-to-drink, high-protein beverages by helping beverage manufacturers more effectively ... dairy proteins, providing direct cost savings as well as more stable pricing over ...
(Date:4/25/2017)... ... April 25, 2017 , ... Bellus ... that’s the first in a new class of photodynamic cosmetics (PDC). , Allumera® ... skin, visibly reduce outward signs of aging, and minimize the appearance of pores ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... BOSTON , April 20, 2017   ZappRx, Inc ... the specialty drug prescribing process, today announced it closed $25 ... Fund, a venture capital firm based in Seattle ... Qiming Venture Partners . The Series B round included ... A round in 2014, and GV (formerly Google ...
(Date:4/20/2017)... April 20, 2017 NeuroVive Pharmaceutical AB ... announced positive preclinical results demonstrating anti-fibrotic effects ... non-alcoholic steatohepatitis (NASH), in an additional well-validated ... NV556 has previously shown similar anti-fibrotic effects ... NeuroVive,s scientists present novel data demonstrating anti-fibrotic ...
(Date:4/19/2017)... The Mobile X-Ray product segment is the most ... the forecast period Mobile X-Ray segment is the ... X-Ray devices market, which is estimated to be valued at ... CAGR of 7% over the forecast period. Mobile X-Ray segment ... US$ 100 Mn in 2017 over 2016. The segment,s revenue ...
Breaking Medicine Technology: