Navigation Links
Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
Date:12/8/2012

l influences such as access to care or oral medication compliance. Of the 492 patients, 138 (28%) had the SNP rs16754 (SNP+). After stratifying the patients by ethnicity, the investigators found that the presence of SNP rs16754 varied by race, with 53 percent of Asians, 34 percent of Hispanics, 25 percent of Caucasians, and 21 percent of African Americans carrying the genetic variation. The SNP+ patients had higher five-year overall survival rates than those without the variation (SNP-) (61% vs. 44%). Within each racial subgroup, the five-year overall survival rate was higher in the SNP+ patients.

Although survival improvements in leukemia clinical trials are often attributed to increased remission rates or decreased relapse, remission and relapse rates did not differ significantly between SNP+ and SNP- patients in this study. The investigators examined whether the SNP had any association with TRM and found that TRM rates did not differ by SNP rs16754 genotype when all ethnicities were considered together. However, TRM rates in SNP+ African-American and Asian patients, when taken together, were significantly lower than in SNP- patients of those two ethnicities. African-American and Asian patients without SNP rs16754 had significantly higher rates of treatment-related toxic death compared to SNP+ patients (African-American: 25% vs. 0%; Asian: 43% vs. 0%). These results suggest that the protective effect of the presence of SNP rs16754 in reducing chemotherapy-related toxicity in pediatric AML patients is more pronounced in those of African-American and Asian descent.

"Identifying the patient-specific factors that can affect responses to treatment in different patients with the same disease brings us closer to our goal of designing personalized treatments that provide the most therapeutic benefit with the least amount of toxicity to these children," said Phoenix Ho, MD, lead author and Attending Physician at Seattle Children's Hospital in the Divisi
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine news :

1. John Theurer Cancer Center to present 37 studies at the 2012 ASH Annual Meeting
2. Benefit6 Whole Body Protection, a New Product by I Do Strive LLC, Provides Increased Energy Production According to Recent Studies
3. Sharp spike in computer-related injuries predicted for medical workers, find studies
4. Analysis of conflicting fish oil studies finds that omega-3 fatty acids still matter
5. Studies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care
6. New studies show effects of mammography guideline changes
7. 2 NIH studies show power of epidemiology research; Underscore need to address health disparities
8. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
9. Cancer Drug Reduced Relapses in MS Patients: Studies
10. University of Houston India Studies Program presents Circuits of Empire: India as Metropole
11. Studies Show Limits, Promise of Laser Removal of Tattoos
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... ... Renowned rhinoplasty surgeon and Symposium Chairman, Dr. Rod J. Rohrich ... be held from March 4th - 6th, the 2016 (a previous announcement had stated ... Designed to take participants from the basic training and fundamentals of nasal surgery through ...
(Date:7/3/2015)... ... July 03, 2015 , ... Smoothies are all the ... good blender and easily accessible, quality ingredients. Aurora Natural is proud to introduce a ... added boost of fiber, protein, antioxidants, vitamins and minerals! , Aurora is offering a ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ... the latest and coolest technology products available to consumers. Amanda Forstrom, a technology expert ... selfie sticks are great for documenting memories. , Almost every smartphone has an incredibly ...
(Date:7/2/2015)... VA (PRWEB) , ... July 02, 2015 , ... sweetFrog ... Albany, Mississippi. The opening is the first sweetFrog store located in Mississippi. The premium ... growing companies in 2014. , The store, located at 104 Railroad Avenue, New Albany, ...
(Date:7/2/2015)... ... 02, 2015 , ... The American Association of Poison Control ... Overdose Stat (S.O.S.) Act of 2015 on June 23, 2015. Together with the ... decrease drug overdose – especially of heroin and opioid medication – by expanding ...
Breaking Medicine News(10 mins):Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Aurora Product, Inc. Announces An Original New Line: Smoothie Fixins’ 2Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetfrog Opens First Location in Mississippi 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3
... Concern among Mothers Regarding,Protecting Children from the ... Today the National,Association of Child Care Professionals ... Influenza Immunization Coalition (CIIC) are,launching their second ... about the seriousness of influenza in children, ...
... occur through 2013, according to Millennium,Research Group, ... Group,s (MRG,s) US Markets for Biopsy Devices 2009 ... the number of,gastrointestinal (GI) and breast biopsy procedures ... with microscopic capabilities for,visualizing tissue at the cellular ...
... Lakes Cancer Institute Will Be Expanded With ... To Cancer ... Patients, FLINT, Mich., Nov. 12 ... healing may,become an easier task thanks to a grant from the American Cancer ...
... Calif., Nov. 12 Hyperion,Therapeutics, Inc. today ... Phase,2 clinical trial designed to evaluate the ... versus BUPHENYL(R) (sodium phenylbutyrate),the current standard of ... Data,from the trial will be presented at ...
... Fla., Nov. 12 With a story that ... to thousands of those,awaiting lifesaving transplants, golfer and ... champion the cause of organ,donation as he pursues ... today at,Southern Hills Plantation Club in Brooksville, Florida., ...
... DOYLESTOWN, Pa., Nov. 12 Quigley Pharma Inc.,a wholly-owned ... today that the last subject in the Phase IIb ... This will effectively move the,study to the final stage ... collecting all the patient information from,21 Study centers and ...
Cached Medicine News:Health News:NACCP, Families Fighting Flu, and the Childhood Influenza Immunization Coalition Team Up to Educate Families About Annual Childhood Flu Vaccination 2Health News:NACCP, Families Fighting Flu, and the Childhood Influenza Immunization Coalition Team Up to Educate Families About Annual Childhood Flu Vaccination 3Health News:NACCP, Families Fighting Flu, and the Childhood Influenza Immunization Coalition Team Up to Educate Families About Annual Childhood Flu Vaccination 4Health News:NACCP, Families Fighting Flu, and the Childhood Influenza Immunization Coalition Team Up to Educate Families About Annual Childhood Flu Vaccination 5Health News:Advanced Imaging Technologies to Limit Breast and GI Biopsy Procedures 2Health News:Idea to Arm Cancer Patients with Information Specific to Their Disease and Treatment Receives Nod, Grant from American Cancer Society 2Health News:Idea to Arm Cancer Patients with Information Specific to Their Disease and Treatment Receives Nod, Grant from American Cancer Society 3Health News:Hyperion Therapeutics Completes Phase 2 Data Analysis and Schedules End of Phase 2 Meeting With FDA for HPN-100 in the Chronic Treatment of Urea Cycle Disorders 2Health News:Hyperion Therapeutics Completes Phase 2 Data Analysis and Schedules End of Phase 2 Meeting With FDA for HPN-100 in the Chronic Treatment of Urea Cycle Disorders 3Health News:Millions Follow Erik Compton's Quest to Win a PGA TOUR Card and Build Awareness for Organ Donation 2Health News:Millions Follow Erik Compton's Quest to Win a PGA TOUR Card and Build Awareness for Organ Donation 3Health News:Quigley Announces Completion of Phase IIb Clinical Study of QR-333 For Diabetic Peripheral Neuropathy on November 25, 2008; Collection and Evaluation of Study Data to Begin Immediately Thereafter 2Health News:Quigley Announces Completion of Phase IIb Clinical Study of QR-333 For Diabetic Peripheral Neuropathy on November 25, 2008; Collection and Evaluation of Study Data to Begin Immediately Thereafter 3Health News:Quigley Announces Completion of Phase IIb Clinical Study of QR-333 For Diabetic Peripheral Neuropathy on November 25, 2008; Collection and Evaluation of Study Data to Begin Immediately Thereafter 4
(Date:7/3/2015)... , Mexique, July 3, 2015 ... continue cible les épidémies que sont l,hypertension, le ... par l,intermédiaire de plateformes éducatives gratuites et d,une ...      (Photo: http://photos.prnewswire.com/prnh/20150630/227033 ) , ... diabète en ligne , Prendre en charge ...
(Date:7/3/2015)... Der Pharmariese Lupin ... eine 100-prozentige Beteiligung am Unternehmen ZAO "Biocom" ... Übernahme dringt Lupin in den russischen Pharmamarkt ... Mrd. RUB im Jahr 2014 zu den ... Health). Seit über einem Jahrzehnt verzeichnet der ...
(Date:7/3/2015)... Redwood Pharma AB has entered into a ... both the US and China , ... hydrogel technology in its lead chronic Dry Eye therapeutic ... technology offers many unique competitive benefits. At lower temperatures, ... low concentrations of polymer the system can be transitioned ...
Breaking Medicine Technology:Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: